COM 0140.006 2002-2004 - Laserfiche WebLink

Home

a~tendin_ periods o[ abstinence. It is noteworthy [hat twenty-nine of[he thirty-five patient, success[ulh treated with Ibogaine had numerous mtsuccesshd e.eperiences with other treatment uwdali[ies- .-A BRIEF HISTORY Ibogaine a naturally occurring alkaloid found in Cabernanthe iboga and other plain species of Central W-est Africa. Deus firs[ reported to be ettective in interrupting opiate naraxic dependence disorders m C.S. patent -V.-199,096 ILotso[: 1985); cocaine dependence disorders m l ~.5. pa[em X587.243 1 Lotsot: 19861 and poll-drug dependence disorders in U.S. pa[em ~.I i_.y94 fLutsof t99_' fhe initial studies demonstrating Ibogaine's effects on cocaine and heroin dependence were accomplished in a series of focus group o~perimen[s b~ H. 5. Lutsof m 196'_ and 1963. Additional data on the clinical aspecb of Ibogaine in the treamtent of chomicul dependence were reported h~ huplan f 199; Sisko 119931. Sanchez-Ramos X Mash 1 19941. and Sheppard[ 1994 i_ Prior to Ibogaine's e~aluanon for [he interruption of carious chemical dependencies. [he use of Ibogaine was repotted in ps~chotherap~ by Naranjo i 1964. 14731 and tit the First In[emational Ibugaine l onference held in Paris ILeff. 1987 the use of Ibogaine-con[aimng plants has been reported Ibr centuries in W zst At}ica m both religious practice and in traditional medicine ~ Fernandez. 198'_; Gullnhofer K Sillans 1983. 198? 1 :An open iew of the his[ur~ of Ibogaine research artd tuc win published b~ C~outarel et ?I. 1199; Claims tit edicacy in treating dependencies to opiates, nrcarne. and alcohol in human subjects were supported in preclinical studies by researchers in the Cni[ed States, the Netherlands and Canada. Droljic et al_ i 19881 were the ties[ researchers to publish Ihuguine's ability ro u¢enuate narcutic withdrawal. Stanley U. Glick zt ul. 1149'1 at .4lbam Medical College published onginal research and a rr~iew of the field euncenring the uttenua[ion of narcutic withdraw al. ~laisumreu~e zt al. ~ 14411 dztzmuned the phamtucologicul in[errc[ions between Ibogaine and morphine, and Glicl. et ,il_ i 1991 reported IbugaineS ability io reduce or interrupt morphine self-administration in the rat. Woods e[ ?I. f 199[1 I limed that Ibogaine did not act as tin opiate. and ~Aceto z[ al_ 1 1991 r established [hat Ibogaine did not precipitate withdrawal signa or cause dependence. Cappendijk and Dwljic i 14431 published Ibugaine's e[fezl m reducing cocaine sel6admiuistra[ion m the rat. Broderick zt al. i 19421 hest published Ibugaine's ability to re~sse zocaine-induced dopamine increases and later. on Ibogaine,, reducnun o[ cocaine-mduzed motor acti~in and other etlecb 119941. Brodenzk e[ aL~s research suppurred the findings of Sershen et uL 1199'_1, that Ibogaine reduced cocaine-utdueed motor s[imulauon in the arouse. Sershen ~ 19v.11 also denwns[rated that Ibugaine reduced the consurnpuon ui coemnz m mice. Glick 1199'_ 1 and Cappendilk 119931 discovered in the animal model that multiple administrations o[ Ibogaine over time were more ettecuse than a single dose in interrupting or at[enuatina the self=administmtiun of morphine and cucairte_ supporona Lotsofs findings in human ,objects t 198~L Pupik et al. t 19941 deteimuied Ibogaine [u be a competitive inhibitor of X16-801 binding to [hc NMDA receptor zumplev. Vlti-801 hua been shown to attenuate tolerunce to opiates 11ru~illu ~ Al.il 1491 i and alcohol I Mhanna e[ al. 1 44: r. Mli-801 has also shown a blockade of "retene tolerance" of stintulunts ~ I<urler z[ uL 19841. Ibogaine s rflects on dopamine. a substance h~ puthesizrd to bz responsible fur remturcing pleasurable et2~ects u[ drugs of abuse. .utd the dopamutr stem were found b~ ~laisonneu~e et ul. t 1991 1. Broderick et ul. l 19921 and Senhen zt al. 1 199'_ 1. Ibugaine binding to the kappa opiate receptor was reported by Deecher z[ al_ i 199^l. Chas we been ro see a broad spectrum of mechanisms b~ which Ibogaine ina~ moderate rue of substances ~o dig erse us opiate narcotics, .umularns and alarhoL l'LINIC.AI PItACIICI_