COM 0140.006 2002-2004 - Laserfiche WebLink

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admimstmtiunl. possibly to be a psychosomatic reaction [u preciously repressed truwnahc z~periences. In addition to keeping the patient as- still as possible, we use a non}~henuthiaunz anti-nauseant, as phenothiazines may interfere w-ith the psy choactie~e propenics of lbogaine. If the patient vomits in less than two and a halt hours after the administration of lbogaine, an esaminatiun of the regurgiwted material should be made to determine how much lbogaine may have already been absorbed b~ the patient- .A rectal infusion of lbogaine to supplement the lost portion of the dose mas be provided if it is not possible [ur this dose to be administered oralls. Che rectal administration should occur onls if the patient has pees iuush consented to this mode of dosing- B. l~ L5 t' AL ILA C LO N Use of Ibogaint s principal ettects during its first phase of action is to produce .i ,rate which emulates dreaming. aside horn the fact that the subject is tulh awake and has the abilits to respond ro [he treatment xaN's yuestiuns. Inmost cases. people under [he m[luence of a therapeunc dose of lbugame do nut wish ro speak. Chet' pretcr instead [u pay close aaen[ion to the eisual presen[auun ut memories ur phenomena the. are experiencing, that have been noted to have bush Freudian and Jungian connotations Che experiencing of sisual matenal is rapid. Some patients hase described it as a mode run at high speed: others us a slide show, each slide containing a motion picture of a specific es ent ur circwnstance in the viewer'; lili. In either case. [he presentation of sisual matenal is so compressed and thst mining that distracting the patient fur even a moment may interfere ~roiih [he process of abreaction- Cherefore_ in trcamtent_ the intrusion of the ntedicul staff should be Lept to a minimum during Ibugaine's primary phax- Al' CONOMIC RESPONSE-S Uuring the ties[ through the htth hutU there is a moderate rise in blood pressure ul ten to [itieen percent .utd. in some cases. an associated decline in the pulse rate I'he must ntgnihcant autonomic changes occur between one and a half and two and a halt hours atter adntinistratiun of therxpeu[ic doses of Ibogame. In mtam cases the patients pulse rates ore clesated due to ansiets prior to the administration of lbogaine. Un two occuaions, persons with uunsiant hypertension scare [reared. In one uRhme instances the patient's blood pressure dropped to normal Ie~els during [he printan and second'an swgzs of treatment. I-hz second by per[ensne zchibited little change at u_3mg,'kg therapeunc dose, ben showed sienihcant changes on two uccasiuna when prodded with onh a I.bmg'kg tzst dose. fhe n~u Lbmg,kg doses were supplied due to utv concern over the patient's hypertension. He had been pros iuush u-eared with an I Smg, kg~ dose by Uu[ch Addict Sel[-Help I DASH I wrth nu appwem negutisc results. Chu alley iuted sumzw ha[ our concern Ibr the patient's safes l-anatiun in indis iduul patient reucnons ,huuld he anticipated. FEMAL E P.~ CIEN 1' SAFE I t' One ~1-~eur-old Cemale patient treated wnh lbogaine [br chemical dependence dted IFum undiagnosed causes in the Netherlands. Although her autops did nut determine the cause of death- it reposed lbogaine les els of U.75mv~li[er in blood. This level has out been seen to be tu.ate m animal research or in our pnur hwnan studies. ~ubseyuent to thin death and to a pros ioush rrporel death of a Swiss woman who receised Ibogame during a psychotherapy session in k;urope. [uarlh unrelazed nsNDA'~ research program, the FDA zscluded women tiom the present clinical trials taking place at the Universm of Miami. Howes er. the FDA decision is cwnrary to the gender gwdelines u[ the National