COM 0314.057 1996-1998 - Laserfiche WebLink

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` ANTICANCER ACTIVITY OF CANNAAINOIDS 599 / TABI,B I. Effed of 'NC on tams protof)r and aurpipol lime of mica hon. Levin luny portinoma Tumor welghla (g) at Treatment Dees Hody w•tight h[ean survival Incrcaeed mg/kg 'change (g) / 12 days • l9 days • 30 days • time (dsye) life-epsn, % Control (BSA 7.5%)------ - +1.5 892tIb0 3,4581252 5,883}873 25.8}1.3 - t 5•-TIiC._•______________ 25 10.9 4G8(t107 ~ 2,363}148 ~ 4,3371278 a 30.312.0 17.4 / p b0 -0.3 253t118e 2,1681105• 4,8.91) 27.4f0.G 8.2 (8) (8) (I) p•.TIiC_________________ 100 -0.1 221f98e 2,307t382e 4,888t312e 35.Ofl.ld 38 • Group of mica Wert Inecult4d Im del, 1X10• Lr.b Iona eslh toil veiteJ welly br 10 dtya allh e••TIIC. t Nho6 body welRht ehinib albs 10 dsye of Irnlmenl. • Post lamer ImpbnY; tumor welthM wart deflved tram mtuurem<nt of minor ind miner ntr. Tdun to momdai: number e(ml<e ue Indioted in pinnlAnn. r P <0.08 a eompirtd b <on4pb. TAet.e 2. ~j7eH of n'•TIlC on Tumor prolrth and aunilnl time of HDFt mice hotline Leln'i loop cprttinonm Tumor w•eighUt (g) at Trenlment Urme Body w•eiRhl i1(esn altrvival Incrcntetl mg/kg change (g) i l2 dnya • 21 dsye • lime (Joys) lileapnn, Control (BSA 7.b%)___.______ - -I.8 O21f30 4,880~38U 30.StU.9 (30) (3U) dl-T[iC._.____,__••_•••.--_. b(1 -0.9 238}48 • 3,IWt2i4 a 37.4}1.7 a 22.0 r IOU -3,4 184}38 a 2,TJ9t238 d 34.311.9 12,4 (71 (7) nt-THC•._-.____•-..-.•._•_. 2IX1 -1.8 174153 • 3,IBSt389 a 38.011.9 a 24.6 (8) (8) ot-TFIC_________________•_:_ 4W -3.3 235178 a 3,1941413 d 38.811.2 ~ 27.2 (81 (8) Cy'clophoephsmide.__.. 2U -4.0 0 e 2, 94Ut 1U4 a 40.811.8 ~ 33.0 (81 Pyrall eopolymer_____________ SU +0.3 122188 • 1,Si8fli4 a 42.Sf3.3 a 39.3 (8) (A) • GrouN of malt BDF, mI<r .err Inaculiled Im whh 10. 6wla IenR rorrinomi eelb ind Weed mdly dilly rllA a••TIIC untll.dnth. CyelephoepMmlde inJ pynn copolymer .ere tdminhlered Ip for 10 eot+eeeully dq•i heilnnlnR as houn titer bmor htoeululon. / w'hola beds weitht ehintn after 10 diyr of IrcUn,ent. _ • Port lamer Imp6no; tumor weliMa arts dnhrd Irem mawnment el major ind minor tamer un. TJun m mnmtee; number of mist ne InAI• ~ turd in perrnlFuu. • P <0.08 a compared to eoNro6. TaBi,e 3.-F.Qrrl of ClJA' on Olmar prcu•th and aunirnl Time in l1DFt mitt hoelinp Lrlni loop rarrinoma Tumor wrighln (g) sl T Trenlment Dunn Ilmlp wcipht \lenn anrvivnl Inrren.•ed ~ mglAg ehnngc (g) / 14 dnya • '24 dnya • lime (dnya) lik-npan, Cutttrol (DSA 7.5 +8.3 1,2`IAf 140 5,52(IfSGO 28.011.3 CItV (211 (21) 25 -O.G 11G5f 140d 0.74:1 t37U 2U.Ofl.2 12 (R) I~1 CbY_______________________ LtI -11.0 6ibfllbe b,i U!It?!11 33.id:1.6 2i • (G> (a) Clt~ 1W -2.c z99dals• 4,R43t4c2 2r.8t9.9 3.5 (7) (7) • Grm,pi of mice Inotolited im with 1X10• Lewlr Iona eelh ind treated orally dilly with d••TIIC or CAN until dn1A. • 1\'hola body' weliht ehintn iUer 10 Jq~• of Irolmenl. • Pmt tamer Implmti; wmer we4hu .ere derlred Irem mnwrrmrnt of mibr and minor tamer im. t'Aun ve meim See: number of mks irr indl- r11M1I In pe•r NAI<Ir. • P <0.08 a rompued to eonvob. phamitle/kg. Pyran copolymer, an immuno~rotentiator was obsers•etl on clay 2~1; hotrner, these animals did sut• (1?) when administeral at 50 mg/kg, also significantly vice tie: longer. increased the survival time of the animals (5J.5^:). C[SU, administered at 2r or 200 mg/kg daily until CIlN, administered by gavage daily until dcaQi, dcns• death, showed no unnor-inhibitory fsrolxrtics as mcas- atstrated antitumor activity against the Leivis lung card- ured by primary Lewis lung tumor size or sun•ival time ' noma when evaluated on clay 1•I post honor inoculation (table 4). In this experiment, CBD~treated mice show•erl ) (fable 3). Primary tumor growth w;ts inhibited by ii".: at enhanced primary tumor growth. liowever, the control doses of l0U mg/kg on clay 14 but only by I I".: on clay :I. tumor growth rate in this experiment w•as decreased as At SU ntg/kg, C11N inhibited rimary tumor ~rowdi by cmnpared to the (Irevious studies. only 52e.: s+•hen measured on t~ay 14, and no inhibition Survival time o[ 1[UF, mice hosting [.1210 leukemia