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1/ <br /> '1RICLOPHR; O O <br /> Ref: pp. 145 4. Human Health Effects <br /> a. Hazard Identification <br /> (1) Acute Toxicity and Mechanisms of Action <br /> para 1 Although the toxicity of triclopyr is relatively well <br /> characterized, the mechanisms of action in mammals are <br /> unclear and there are NO clinical or epidemiology studies <br /> regarding toxic effects in human s. <br /> Triclopyr is a pyridine analogue of 2,4,5 -T. <br /> PYRIDINE: A toxic water - soluble flammable liquid heterocy- <br /> clic base C <br /> HETERROCYCLIC BASE: Rings of atoms of differant elements. <br /> Ref: pp. 145 (1) Acte Toxicity <br /> para 1 However, many of the potential health effects of 2,4,5 -T <br /> [the pyridine analogue to make triclophr] are related to <br /> the occurrence of 2,3,7,8 - tetrachlorodibenzo -p- dioxin <br /> (TCDD) in 2,4,5 -T. This containminant is NOT likely to <br /> be present in the triclophr fomulations. <br /> Point to <br /> Pounder Do we want the chance of "NOT LIKELY" to be <br /> accepted invohring such a hazardous chemical as this? <br /> Remember that the pyrindine analogue has the <br /> word DIOXIN attached to it. One of the most toxic <br /> compounds known to man. Remember the area known as <br /> "The Love Canal" incident. <br /> Ref: pp146 (2) Role of Inerts <br /> para 1 GARLON 3A contains ethanol. <br /> para 2 Ethanol's toxicity is exteremely well daracterized in <br /> humans, and the hazards of exposure include intoxication, <br /> as well as liver cirrhosis and fetal alcohol syndrome <br /> (WHO, 1988). <br /> Ref: pp 147 GARLON 4 contains kerosene <br /> para 1 The material safety data sheet (MSDS) for Garlon 4 <br /> specifies that inhalation exposure to Garlon 4 vapors <br /> may cause CNS depression attributable to kerosene <br /> (DowElanco, 1994). CNS depression is consistent with <br /> exposure by inhaling kerosene (ATSDR, 1995) <br /> Ref: pp 154 (1) Existing Guidelines <br /> para 1 The U.S. EPA's Office of Prevention, Pesticides, and <br /> Toxic Substances, which is responsible for the <br /> registration of pesticides, has derived a provisional <br /> RfD for triclopyr of 0.005 mg /kg /day (U.S.EPA, 1995d). <br /> RfD: (Referance dose) Oral dose not likely to be associ- <br /> ated with adverse effects over lifetime exsposure <br /> in the general population, including sensitive <br /> subgroups. <br />