HomeMy WebLinkAboutCOM 0771.523 2020-2022 [�7777
M . 771
My name is Chris 'Donnell and I will be testifying on behalf ofl r.Dianne Godar,who earned
her PhD in Chemistry from Georgetown University and worked for the US hood Drug
Administration for 33 years. I a€ar in strong support of Sill 167.
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Petrochemical u scr us deo not prevent melanoma, 3
Dianne B.Uodar,PhD
The most important paper declaring sunscreens do not prevent skin caners was published by the ��=
International Agency for Research on Cancer(1ARQ [11. Dermatologists believed sunburns caused %ate
melanoma so they thought sunscreens,which prevent sunburns,would also prevent melanoma. However, °a
that belief turned out not to be true, _
Quote from their abstract: "No conclusion cern he drawn about the cancer-ppevenfive activity of topical
use of. unscreens against basal-cell carcinoma and cutaneous melanoma Use of sunscreens can
extend liras duration of intentional sun e pavure,such as sunbathing.Such an extension rr q a'ncreave
rise risk jor°cutaneous eland a.as
Godarr et al.analyzed in the charts below the incidences of melanoma in 5 continents around the world of
males(trop)and ferrules(bottom) in 5 age groups(0-14 years bottom lime to 70+years top line)using
IARC data. They found the incidence of€nelanoina(Y axis)does not significantly increase(p>0.05)with
increasing;UVB dose in the fair-skinned countries of Australia(on the left),the US(middle)and Europe
(right)suggesting terrestrial UVB(290-320 nrn),which causes sunburns, is not responsible for causing
melanoma[2].The flat lines representing the age groups in males and ferrules show no increase in
melanoma with UVB dose.The 0-14 slope with UVB dose in Australia is not significant.
Surprisingly, in Europe they found a reverse correlation of melanoma with UV13 dose,that is the
incidence of melanoma increased with decreasing UVB dose,with remarkable significance(p<2x 10-')
[31. In addition,they found the exponential increase in melanoma for 5 decades had incredible
significance(p<l0-").The reverse correlation data suggests UVA (320-400 nm)plays a significant role in
causing melanoma rather than UVB because the ratio ofUVA to UVB increases with increasing latitude.
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Increasing UVB Dose (Jai
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Ref. : P
Ref. Date JPONI . 15-222
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As shown below, the higher incidence of cutaneous malignant melanoma( Tull)in northern
Europe also implicates U A rather than UVB as the main initiator of melanoma.
N.Europe ( 5 'N;mean 11N)
A told Europe — 1- ° !;mean—52"N)
S.Europe(45-50'N; man-47'N)
2
10
� m
1
1950 1970 1990 2010
Table SA, Statistic% for multiple linear regression of log(C MM incidence)
data versus time and UV dose in all of Europe i
Predictor Curet T
Year 0.02 20
UV Dose —5A 2.0 x tom'
Sunscreens that primarily attenuate UVB have been available for decades and the SPF factor
increased from 15 to tOO offering even more protection over time;however,the slope of the
limes for the incidence of melanoma over 5 decades did not decrease or alter its exponential
increase in Europe,Australia,or the U [4]. UVA transmission is allowed by ineffective
sunscreen chemical formulations,allowing the longer wavelengths of U'V`A1 (340-400 nm)to
penetrate deep into the skirt causing mutagenic DNA damage via oxidative stress.
[1]Vainio H,Miller AB,Bianchini F:An international evaluation of the caner-preventive potential ofsunacreens.
Int J Cancer 2000;88(5):838--42
[2]Godar LSE,Subramanian M,Merrill Si:Cutaneous malignant melanoma incidences analyzed worldwide by sex,
age,and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin Lis,
Dermatoendocrinol 2016;9(1):e1267077,doi: I 1080/19381980.2016.1267077.eCollection 2017,
[3]Merrill 5J,AshrafiS,Subramanian M,Godar DE. Exponentially increasing incidences of cutaneous malignant
melanoma in Europe correlate with low personal annual UV doses and suggests 2 major risk factors.
Derrrratoendocrinol,2015 Feb 27;7(1):e1004018,doi: 111.1 08011 93 8 1 980.2014.1004418.eCollection 2015)an-Dec,
[4]Merrill SJ,Subramanian M,Godar DE:Worldwide cutaneous malignant melanoma incidences analyzed by sex,
age,and skin type over time(1955-2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor
for developing melanoma exclusively in people of European-ancestry?L'termatoendocrinol 2016;8(1):el215391.doi:
10.1080/19381980,2016,1215391,eCollection 2016 Jan-Dec
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