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HomeMy WebLinkAboutCOM 0639.016 2008-2010 BRENDA J. FORD Council Member District 7 - Central Kona Phone: Fax: E-Mail : (808) 326- 5684 (808) 329- 4786 bford@co.hawaii.hi. us HA W AI'I COUNTY COUNCIL County of Hawai 'i Kailua Trade Center 75-5706 Hanama Place, Suite 109 Kailua-Kona, Hawai'i 96740 l"'3 => <::::::> <:::::> o 00 C(:) z;c::. ~ "-....., :? :,~:~ C-- ::0 Z :0 m "........, \ .~; ~~"-r":; ........ c...,) \!l :3 DATE: January 8, 2010 Q :? IT! ~, \....,.1 TO: J Yoshimoto, Chairperson, and Members of the Hawai'i County Council Brenda J. Ford, Council Member ~~ ':J~ J: o FROM: SUBJECT: A report on "Drug Abuse Warning Network, 2006: National Estimates of Drug- related Emergency Department Visits" from the U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration in reference to Resolution 281-09 encouraging the decriminalization of the use of marIJuana. The attached 2006 report provides statistics on emergency department visits based on alcohol, marijuana, and other drugs compiled by the Drug Abuse Warning Network (DAWN). Please provide a copy of this report to each council member for review prior to the council meeting scheduled for the January 22, 2010. The council members will need as much time as possible to review the document. BJF/ Comm. No. &: 1; q ./ fa Ref. TO:-=p{~r Ref. Date. JAN 2' 2. Serving tile IlIterests (~ftlle People (~f Our Island Hawai'i COUlltv Is An Er/llal O/J/Jortullitv Provider And EI1l/Jlover \) ~. OFFICE OF APPLIED STUDIES Drug Abuse Warning Network, 2006: National Estimates of Drug=Related Emergency Department Visits U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Substance Abuse and Mental Health Services Administration http://DAWNinfo.samhsa.gov/ o 'I> 831'v'1'I1183 03 1'v'NOI1'v'N :900<: 'NM'v'O (': 900i:lsn6nv L990i: OV\l 'aIlIMpOCJ 'PPO~-L WOOCJ 'p80CJ NJa4J a~04J ~ Sa!pnlS pa!lddV!O a:J!HO UO!jeJ1S!U!WPV Sa:J!fUas 4118aH 181uaV\l PU8 asnqv a:Ju81sqns 381:1:10 8NIl V'NI81~0 '(10\J8ds3 PU8 4S!16U3) (LGL P-9GL- Ug-~) L-VSHV\lVS- Ug- ~ :je ~JOMlaN UO!18WJO!UI 4118aH S,VSHV\lVS 118:J aS8ald JO 'Lujysa!do:J/MB8S4weSS80/rdu4 WOJ! paU!81qo aq A8W saldo:J PJ8H ^06eS4W8S'S80/rdn4 WOJ! 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S! uO!j8:J!lqnd S!41 U! 6U!J8add8 18pal8W IIV 38110N NIV'~OO 81lSnd YV\I 'U8JOV\l 8U!!aSOr !O uo!paJ!p a41 Japun 9G06-i:0-Sgi: 'ON P8J1UOJ Japun 181saM Aq papnpuo:J S8M UO!pallo:J 818P NMVO a41 '(11CJ 'U8P!IS!181S) YV\I 'laI4:JaJ::J Jalad PU8 '(11CJ 'lsAI8UV) 'O'4d '46n8qw81S 81Aal '(11CJ 'U8P!IS!181S) 'O'4d '!~IOJ)lIOJ8)1 '(11CJ 'lsAI8UV) 'S'V\I 'aaUOIl8V\1 uP3 '(SVOI\fSHV\lVS) 'H'd'V\I 'l!a\aUOd 'V\I A418)11dVJ papnl:JU! SJOlnqpluo:J lU8:J!!!u6!s Ja410 'UO!j8:J!lqnd a41 aloJM (11CJ 'JopaJ!O parOJd) YV\I '146pq1V 8POP!^ PU8 (SVOI\fSHV\lVS 'JopaJ!O parOJd NMVO) Yd'V\I "O'4d '1188 ')I Apnr 'G09i:-SO-Ogi: 'oN P8J1UOJ Japun 18UO!18uJalU111CJ 41!M (SVO) Sa!pnlS pa!lddv !O a::>~!o '(VSHV\lVS) UO!jeJ1S!U!WPV sa:J!fUas 4l18aH 18luaV\l PU8 asnqv a:Ju81sqns a41 Aq paJ8daJd S8M UO!18:J!lqnd S!41 SlN3 V\J 80 3lMO N >18 V' "tJ> \:) ',-'.1;' CONTENTS Page Acknowledg ments............................................................................................................................ 2 High lights............................................................................................................................. ............. 7 ED visits involving drug misuse/abuse ......................................................................................... 7 Illicit drugs in ED visits.................................................................................................................. 8 Alcohol and drug-related ED visits................................................................................................8 Alcohol in combination with other drugs.................................................................................... 8 Alcohol in patients under age 21............................................................................................... 9 Nonmedical use of pharmaceuticals ............................................................................................. 9 Comparisons in drug misuse and abuse: 2004, 2005, and 2006................................................ 10 Special types of drug-related ED visits....................................................................................... 10 Suicide attempts ... ....................... ................. ..................... ........... ...... ..... ......... ..... ...... ........... 10 Seeking detox ...... ........ ...... ..... ..... .................... ................................. ...... ..... .............. ...... ....... 11 Introduction......................................................................................................................... ........... 13 Major features of DAWN .............................................................................................................13 What is a DAWN case? .......................................................................................................... 13 What drugs are included in DAWN? ...................................................................................... 13 What is covered in this publication?........................................................................................14 Hospital participation in 2006 .....................................................................................................14 Estimates in this publication .......................................................................................................15 Margin of error for estimates ...................................................................................................... 15 Comparisons across years ......................................................................................................... 16 Margin of error for comparisons across years ............................................................................16 Estimates adjusted for population size .......................................................................................16 Drug Misuse and Abuse in ED Visits ............................................................................................ 17 Illicit Drugs in ED Visits ................................................................................................................. 19 Alcohol in ED Visits .......................................................................................................................27 Alcohol in combination with other drugs (Tables 5-6, Figure 3) .................................................. 27 Alcohol-related ED visits in patients under the age of 21 (Table 7) ............................................ 30 ED visits for underage alcohol use (Tables 4,8, Figure 4) ......................................................... 30 Nonmedical Use of Pharmaceuticals ............................................................................................ 33 Nonmedical use of pharmaceuticals (Tables 9-10, Figure 5)......................................................33 DAWN, 2006: NATIONAL ED ESTIMATES 3 S31Vv.lllS3 03 lVNOIIVN :900(: 'NMVO CI ,~~ v G9 ....................................................................... 900G pue '900G 'VOOG :xOlap 5u!~aas 09.......................................... 900G :S:J!IS!JapeJe4:J I!S!^ pue lua!led Aq 'xolap 5u!~aas 69.................................................................................................. 900G :xolap 5u!~aas 99.................................................................. 900G pue '900G 'vOOG :sldwane ap!:J!ns t9 .......................................900G :S:J!IS!JapeJe4:J I!S!^ pue jUa!led Aq 'sldwane apP!ns 09 ................. ........... ............ ................ .............. ........ ................ 900G :sldwane apP!ns 9v...................... 900G pue '900G 'vOOG :SI!S!^ 03 sle:J!jna:JewJe4d!0 asn le:J!pawuoN W'" 900G pue '900G 'vOOG : ~G aBe Japun slua!jed U! SI!S!^ 03 palejaJ-5nJp U! 1040:J11f W.......................................... 900G pue '900G 'vOOG :SI!S!^ 03 palejaJ-BnJp U! 1040:J11f tv..........................................................900G pue '900G 'vOOG :SI!S!^ 03 U! s5nJp Pili GV'" ............ ....... ...... ......................... .............. ...... ........... ........... '900G pue '900G 'vOOG :jUawa^IO^U! BnJP!o adAI Aq "s'n a41 U! SI!S!^ 03 U! asnqe pue asns!w BnJO Lt.........900G :S:J!IS!JapeJe4:J I!S!^ pue lua!jed Aq 'sle:J!lna:JeWJe4d!0 asn le:J!pawuoN Vt ................................................................ 900G :sle:J!jna:JeWJe4d!0 asn le:J!pawuoN ~t'''''''''''''''''''''''''''' 900G :s:J!jspapeJe4:J I!S!^ pue lua!jed Aq '(~G > aBe) AIUO 1040:J11f Ot...............................900G :~G aBe Japun slua!jed U! SI!S!^ 03 palelaJ-BnJp U! 1040:J11f 6G....................................................900G :1040:Jle 41!M pajJodaJ AlluanbaJ! ISOW sBnJO aG............................. 900G :s:J!jspapeJe4:J I!S!^ pue lua!led Aq 'uo!jeu!qwo:J U! 1040:J11f a......................................................................900G :SI!S!^ 03 palelaJ-5nJp U! 1040:J11f tG .............................................................. 900G :S:J!jspal:JeJe4:J jUa!led Aq 'sBnJp IP!l1I OG.....................................................................................900G :sl!S!^ 03 U! sBnJp 1!:J!11I 8 ~ . .............. .................. ....... ............................. ................. ................ .......... .......... 900G :luawa^lo^u! BnJP!o adAI Aq "s'n a41 U! SIIS!^ 03 U! asnqe pue asns!w BnJO ~ alqel salqel !O lS!l ~G alqel OG alqel 6 ~ alqel 8 ~ alqel n alqel 9 ~ alqel 9 ~ alqel v~ alqel t ~ alqel G~ alqel ~ ~ alqel o ~ alqel 6 alqe 1 8 alqel L alqel 9 alqe 1 9 alqel valqel t alqel G alqe 1 G9 ........................................................ (~G alqel) 900G pue '900G 'VOOZ :SI!S!^ 03 xOlap 5u!~aas 89 .................................................................................... (L amB!.:l 'OZ-6~ salqel) xOlap 5u!~aas v9 ...................................................... (8 ~ alqel) 900Z pue '900Z 'VOOZ :SI!S!^ 03 ldwane apP!ns 6v ..................................................................................(9 am5!.:l 'n -9~ salqel) sldwane apP!ns 6v ..................................................................................... Sl!S!^ 03 palela~-6nJO lO sadAlle!:>ads 9v ..........................................................................(9 ~ a/qel) sle:J!jna:JeWJe4d!o asn le:J!pawuoN VV .............................................................................................(v~ -t ~ salqel) SI!S!^ 03 U! I04o:J11f tV ............................................................................................. (Z ~ alqel) SI!S!^ 03 U! s5nJp IP!11I W......................................................................... (~~ alqel) SI!S!^ 03 U! asnqe pue asns!w 5nJO ~v ....................................................................... 900l pue '900l'vOOl :Sl!S!^ 03lo suos!Jedwo:::l aBed SlN31N08 -------_._---,._------,.._-----,~,~~------_.._.__._----------..---....----------------------- " CONTENTS Page List of Figures Figure 1 Rates of ED visits involving selected illicit drugs: 2006 .............................................22 Figure 2 Illicit drugs, ED visit rates by age and gender: 2006..................................................25 Figure 3 Alcohol with other drugs, ED visit rates by age and gender: 2006.............................29 Figure 4 Alcohol only (age < 21), ED visit rates by age and gender: 2006..............................32 Figure 5 Nonmedical use of pharmaceuticals, ED visit rates by age and gender: 2006 .......... 39 Figure 6 Suicide attempts, ED visit rates by age and gender: 2006 ........................................54 Figure 7 Seeking detox, ED visit rates by age and gender: 2006............................................61 List of Appendixes Appendix A: Multum Lexicon End-User License Agreement ........................................................ 65 Appendix B: Glossary of Terms .................................................................................................... 69 Appendix C: DAWN Data Collection and Statistical Methods ....................................................... 77 Appendix 0: Race and Ethnicity in DAWN ................................................................................... 99 DAWN, 2006: NATIONAL ED ESTIMATES 5 S31lfr/IlS3 03 llfNOlllfN :900Z 'NMlfO .. 9 " HIGHLIGHTS his publication presents national estimates of drug-related visits to hospital emergency departments (EDs) for 2006, based on data from the Drug Abuse Warning Network (DAWN). Also presented are comparisons of 2006 estimates with those for 2004 and 2005. DAWN is a public health surveillance system that monitors drug- related ED visits for the Nation and for selected metropolitan areas. DAWN estimates pertain to the entire United States, including Alaska, Hawaii, and the District of Columbia. The Substance Abuse and Mental Health Services Administration (SAMHSA) is the agency responsible for DAWN. SAMHSA is required to collect data on drug-related ED visits under section 505 of the Public Health Service Act. DAWN relies on a national sample of general, non-Federal hospitals operating 24-hour EDs. The sample is national in scope, with oversampling of hospitals in selected metropolitan areas. In each participating hospital, ED medical records are reviewed retrospectively to find the ED visits that were related to recent drug use. All types of drugs-illegal drugs, prescription and over-the-counter (OTC) pharmaceuticals, dietary supplements, and nonpharmaceutical inhalants-are included. Alcohol, when it is the only drug implicated in a visit, is included for patients younger than age 21; alcohol, when it is present in combination with another drug, is included for patients of all ages. The 2006 estimates introduce several improvements made to the DAWN sampling and estimation methodology. In order to ensure comparability between estimates for 2004, 2005, and 2006, the improvements were applied retrospectively to 2004 and 2005 data, resulting in small changes as compared to early published estimates. ED visits involving drug misuse/abuse In 2006, hospitals in the United States delivered a total of 113 million ED visits, and DAWN estimates that 1,742,887 (confidence interval [CI]: 1,451,086 to 2,034,688)1 ED visits were associated with drug misuse or abuse. Of those ED visits: Iill 31% involved illicit drugs only, iii 28% involved pharmaceuticals only, III 7% involved alcohol only in patients under the age of 21, III 13% involved illicit drugs with alcohol, III 10% involved alcohol with pharmaceuticals, III 8% involved illicit drugs with pharmaceuticals, and III 3% involved illicit drugs with pharmaceuticals and alcohol. 1 The 95% confidence interval (el) accounts for the margin of error of the estimate. It indicates. with a high degree of confidence, that the true population value was between 1,451,086 and 2,034,688 drug-related ED visits. 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Alcohol in patients under age 21 DAWN estimates 76,760 (CI: 60,318 to 93,202) alcohol-related ED visits for patients aged 12 to 17, and 105,675 (CI: 82,757 to 128,593) alcohol-related ED visits for patients aged 18 to 20. Alcohol is an illegal drug for both of these age groups. About two thirds (69%) of the alcohol-related ED visits for minors involved alcohol and no other drug. Taking population size and the margin of error into account: III The rate of alcohol-only ED visits for patients aged 18 to 20 (581 visits per 100,000 population) was 2.8 times that for patients aged 12 to 17 (204 per 100,000), and III Males and females had similar rates. Nonmedical use of pharmaceuticals For 2006, DAWN estimates that 741,425 (CI: 674,198 to 808,652) ED visits involved nonmedical use of prescription or OTC pharmaceuticals or dietary supplements. The majority of these visits (54%) involved multiple drugs. Central nervous system (CNS) agents (present in 50% of nonmedical-use visits) and psychotherapeutic agents (44%) were the most frequent drugs reported in the nonmedical-use category of ED visits. Among the CNS agents, the most frequent drugs were opiatelopioid analgesics (present in 33% of nonmedical- use visits), including single-ingredient formulations (e.g., oxycodone) and combination forms (e.g., hydrocodone with acetaminophen). Methadone, together with single-ingredient and combination forms of oxycodone and hydrocodone, were the most frequent opioids. Once the margin of error is taken into account, these three opioids appeared in similar numbers of visits: III Hydrocodone/combinations in 57,550 ED visits (CI: 43,701 to 71,398), III Oxycodone/combinations in 64,888 ED visits (CI: 49,746 to 80,030), and III Methadone in 45,130 ED visits (CI: 35,870 to 54,389). It is not possible to know, based on the documentation available in ED medical records, the extent to which the source of these drugs is a legitimate prescription, as opposed to other sources, nor is it possible to distinguish methadone used for treatment of opiate addiction from the methadone in pill form, which is prescribed for pain. In fact, methadone may be one of the most ambiguous drugs to categorize in DAWN. When a patient on opioid replacement therapy presents to an ED, methadone may be routinely documented in the medical record, but without sufficient detail to distinguish whether the methadone specifically was related to the ED visit. Among the psychotherapeutic agents, the anxiolytics (anti-anxiety agents), sedatives, and hypnotics were the most frequent, occurring in almost a third (32%) of visits associated with nonmedical use of pharmaceuticals. ED visits involving benzodiazepines clearly outnumber those involving any of the other types of psychotherapeutic agents. DAWN estimates that 195,625 (CI: 167,789 to 223,461) ED visits associated with nonmedical use of pharmaceuticals involved benzodiazepines in 2006. DAWN, 2006: NATIONAL ED ESTIMATES 9 S31'v'I'IIlS3 03 1'v'NOI1'v'N :900l 'NM'v'O o ~ 'S8S0pJ8^0 5nJp OJ P8j!W!ljOU 8Je SjdW8ne 8S84j 'jIS!^ 4:>e8 U! peje:>!ldw! seM 5nJp e 45n041 0 's5nJp ald!llnw pa^IO^U! sldwane apP!nS palelaJ-5nJp JOJ SI!S!^ 03 JO (%S9) SPJ!41 OMl AlleaN o'900G U! sldwane apP!ns pa)ew5nJp JOJ SIIS!^ 03 (VGV' ~ ~G OISB nS~ :IJ) SOB'GB ~ sa)ew!ISa NM'v'O sldwane ap!::l!ns Sl!S!^ 03 palelaJ-6nJp lO sadJ\llepads 'sasn :J!lnadeJa41 JOJ paqp:JsaJd 5u!aq sle:J!lna:JeWJe4d asa41 JO Al!luenb a41 U! sa5ue4:J 01 palelaJ aJe sle:J!lna:JeWJe4d :J!Jpads 41!M paleposse SI!S!^ 03 U! saseaJ:Jap JO saseaJ:Ju! Ja41a4M ssasse 01 alqe IOU S! NM'v'O '%9S paseaJ:Ju! SUO!leu!qwo:J/auopo:JAxo 5u!^10^u! SI!S!^ pue '%vv paseaJ:Ju! SUO!leu!qwo:J/auopo:JOJPA4 5u!^10^u! 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'papalap saseaJ:Ju! lue:J!J!u5!s a41 5u!pJe5atl '900G OISOOG WOJJ %U paseaJ:Ju! 4:J!4M '1040:Jle 41!M UO!leulqwo:J U! pasn sle:J!lna:JeWJe4d II pue :900G 01 vOOG WOJJ %9€ paseaJ:Ju! 4:J!4M '(s)5nJp lP!II! 41!M uO!leu!qwo:J U! pasn sle:J!lna:JeWJe4d IIi1I :900G 01 vOOG WOJJ %vv paseaJ:Ju! 4:J!4M '(5nJp JO adAl Ja410 ou 41!M "a'!) auole sle:J!lna:JeWJe4d l1li :5U!^10^U! Sj!S!^ JOJ papalap aJaM sa5ue4:J 'IUawa^IO^U! 5nJp JO sadAllUaJaH!p a41 ssoJ:J'v' 'JOJJa JO u!5Jew a41 U!41!M S! a:JuaJaH!p luaJedde a41 'S! le41 '900G pue 'SOOG 'vOOG SSOJ:Je alqels seM asnqe pue asns!w 5nJp 01 alqelnq!llle SI!S!^ 03 JO Jaqwnu lelol a4j 'NM'v'O 015u!pJo:J:J'v' 'po!Jad awes a41 JaM 'UO!IIIW GO€ OJ UO!ll!w v6G WOJJ '%6'G paseaJ:Ju! SajelS pal!Un a41 JO UO!lelndod a41 'vOOG Ja^o %6't JO aseaJ:Ju! ue 'Sj!S!^ 03 UO!II!W € ~ ~ JO lelol e paJa^!Iap sa)elS pal!Un a41 U! Slel!ds04 '900G ul 900Z pue '900Z 'POOZ :asnqe pue aSns!w 6nJp U! suospedwo:) 'vv OJ B ~ pa5e SIUa!)ed JOJ Isa4514 aJaM sa)eJ I!S!^ 03 II pue 'salew pue sa\ewaJ uaaMlaq JaH!p IOU PIP sle:J!lna:JeWJe4d JO asn le:J!pawuou JOJ sajeJ I!S!^ 03 E'l :jUno:J:Je OIU! JOJJa JO u!5Jew a41 pue az!s UO!lelndod 5u!~e1 In these ED visits for drug-related suicide attempts in 2006: III The large majority of drug-related suicide attempts (92%) involved pharmaceuticals, Iil More than half (58%) included psychotherapeutic agents, such as benzodiazepines or antidepressants, 11II Slightly less than half (45%) involved CNS agents, primarily analgesics (pain relievers), including both prescription and OTC formulations, I'JI Nearly one third (30%) involved alcohol (but DAWN data exclude visits for adults when alcohol is the only drug), and 11II About one quarter (23%) involved an illicit drug. Overall, there was no significant change in ED visits for drug-related suicide attempts during the time period from 2004 to 2006, but an increase was detected from 2005 to 2006. Increases were evident from 2004 to 2006, as well as 2005 to 2006, for some of the pharmaceuticals frequently involved in suicide attempts, such as benzodiazepines and opiate/opioid pain relievers. Seeking detox DAWN estimates 118,355 (CI: 90,171 to 146,540) drug-related ED visits for patients seeking detoxification or substance abuse treatment services during 2006. However, these visits tend to be concentrated in hospitals with administrative policies that require medical clearance in the ED for admission to these specialized units within the hospital. Therefore, these visits do not encompass the full extent of the demand for these services. Nearly two thirds (65%) of the seeking detox ED visits involved multiple drugs. Illicit drugs and alcohol were common in these visits: 11II Cocaine (49% of visits) and heroin (29%) were followed in frequency by marijuana (19%) and amphetamine or methamphetamine stimulants (7%), and III Alcohol in combination with another drug was implicated in 40% of seeking detox ED visits. Among the seeking detox ED visits, nearly 7 out of 10 (69%) received some type of follow-up care, either inpatient admission, referral elsewhere for detox or substance abuse treatment services, or transfer to another health care facility. However, more than one quarter (27%) of seeking detox cases might not have received the care they sought, because they were discharged to home. No significant changes in ED visits from 2004 to 2006, or from 2005 to 2006, were detected for seeking detox ED visits overall, or for alcohol or the illicit drugs involved in these visits. DAWN, 2006: NATIONAL ED ESTIMATES 11 S31\fV>lllS3 03 l\fNOIl\fN :900Z 'NM\fO z ~ " INTRODUCTION This publication presents estimates of drug-related emergency department (ED) visits from the Drug Abuse Warning Network (DAWN) for 2006, with comparison of estimates for 2004 and 2005. DAWN is a public health . . surveillance system that monitors drug-related ED 'Islls for the Nation and for selected metropolitan areas. The Office of Applied Studies (OAS) of the Substance Abuse and Mental Health Services Administration (SAMHSA), U.S. Department of Health and Human Services, has been responsible for DAWN operations since 1992. Major features of DAWN What is a DAWN case? One of the most important features of DAWN is its expansive definition of a case: A DAWN case is any ED visit related to recent drug use. To be a DAWN case, the relationship between the ED visit and the drug use need not be causal; the drug needs only to be implicated in the visit. This approach accommodates cases where one or more drugs were involved but mayor may not have directly caused the condition generating the ED visit, but at the same time avoids inclusion of current medications that are unrelated. Only recent drug use is included;4the reason a patient used a drug need not be specified; and the criteria are broad enough to encompass all types of drug-related events, including explicit drug abuse. See Appendix C: DAWN Data Collection and Statistical Methods for a full description of DAWN cases and data collected on those cases. What drugs are included in DAWN? DAWN collects data on all types of drugs, including:5 II Illegal drugs, such as heroin, cocaine, marijuana, and Ecstasy, II! Prescription drugs, such as Prozac"', Vicodin"', OxyContin"', alprazolam, and methylphenidate, 11II Over-the-counter (OTC) medications, such as aspirin, acetaminophen, ibuprofen, and multi-ingredient cough and cold remedies, IIIl Dietary supplements, such as vitamins, herbal remedies, and nutritional products, 11II Psychoactive, nonpharmaceutical inhalants,6 III Alcohol in combination with other drugs, and II Alcohol alone, in patients aged less than 21 years.? 4 That is, patients with a history of drug use (and no recent use) are excluded. 5 The classification of drugs used in DAWN is derived from the Multum Lexicon, @ 2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A. 6 To be reportable, a nonpharmaceutical substance must be consumed by inhalation, sniffing, or snorting and must have a psychoactive effect when inhaled. An ED visit involving inhalation of a nonpharmaceutical, psychoactive substance qualifies as a DAWN case even if no other drug was present. Carbon monoxide is excluded from the inhalants. Since 2004, cases involving accidental exposures (e.g., exposure to paint fumes while painting a closet) have been excluded as well. 7 ED visits related to alcohol use alone are excluded for patients aged 21 and over. DAWN, 2006: NATIONAL ED ESTIMATES 1 3 S31V~IlS3 03 lVNOllVN :900Z 'NMVO v. "Sle:l!Ina8eWJe4d )0 asn 8!jnadeJa4j a4j 4j!M pajeposse Sj!S!^ pue 'weJ60Jd jUaWjeaJj asnqe a8Uejsqns e OlU! AJjUa JO Sa8!AJaS UO!)e8!I!XOjap 6u!~aas sjua!)ed JO) Sj!S!^ 'suo!)sa6u! lejUapp8e 'Sle8ljna8eWJe4d 6U!^10^U! sjdwane apP!nS aJe papnl8x3 S e 'a6eJa^e uo 'pa)l!wqns pue punot aJaM SI!S!^ palelaJ-6nJp 9v6'9Vt 'SjJe4::> to Ma!^aJ a41 uo pases 'epa)!J::> ase::> NM\fO a411aw je41 SI!S!^ 03 pajelaJ-6nJp a41 PU!t 01 paMal^aJ aJaM sjJe4::> UO!II!W 9'6 '9001: U! Slel!ds04 6u!ledp!jJed lie SSOJ::>\f 'Slel!ds04 6u!led!::>!jJed U! spJo::>aJ le::>lpaw to Ma!MJ a^!padsOJlaJ e 46noJ41 punot aJe sase::> NM\fO ':::J x!puadd\f U! pap!^oJd S! saleJ asuodsaJ uo I!elap leuo!l!pp\f "eaJe Uel!IOdoJlaw I!OJlao a41 U! %1:' ~L 01 eaJe Uel!IOdoJlaW uOlsnoH a41 U! %g'Ot WOJt pa6ueJ SaleJ asuodsaJ lenp!^!pu! a41 'SUO!S!^!P pue seaJe uel!lodoJlaw paldwesJaM I: ~ a41 JO::l '% ~ '91: seM aleJ asuodsaJ pal46!aM lIeJaM a41 'UO!lew!jsa JOt pasn aJaM le41 elep pa)l!wqns Slel!ds04 901: '9001: JO::l 9002: U! uO!led!:)!l..led lel!dsOH 'sle::>!lna::>eWJe4d to asn le::>!paWUOU to N06ale::> a41 WOJt papnpxa aJe xOlap 6u!~aas JO SId wane apP!ns 6u!^10^u! SI!S!^ 03 palelaJ-6nJO 'lel!ds04 a41 U!41!M Sl!un luaWleaJl asnqe a::>uelsqns JO xOlap 01 UO!ss!wpe JOt 03 a41 U! a::>ueJeap le::>!paW 6up!nbaJ sa::>!peJd a^!leJlS!U!Wpe 41!M Slel!ds04 U! pajeJlua::>uo::> aq 01 pual SI!S!^ asa41 'weJ60Jd jUawleaJl asnqe a::>uelsqns e OIU! NjUa JO sa::>!NaS uO!je::>lt!XOlap 6u!~aas 03 a41 olluasaJd 04M SIUa!led sapnpu! Janej a41 ,,'xolap 6u!~aas" Slua!led pue sldwane apP!ns palejaJ-6nJp :SI!S!^ 03 to sadAlle!::>ads OMl uo uo!pas aleJedas e sapnl::>u! jJodaJ S!41 'uo!j!ppe Uj s'sle::>!jna::>eWJe4d 6u!^10^u! asnqe a::>uelsqns pue 'Ienp!^!pu! Ja410ue Aq lua!jed a41 to 6u!uos!od snop!lew 'lenpl^!pU! Ja410ue JOt paq!J::>saJd le::>!lna::>eWJe4d e 6u!~el '(6u!laqel JO suo!paJIP 01 NeJluo::> "a'!) le::>!lna::>ewJe4d e to asop papuawwo::>aJ JO paqp::>saJd ue41 Ja46!4 e 6u!~el sapnpu! asn le::>!pawuoN 'sluawalddns AJela!p JO SUO!le::>!paw :::J10 JO uO!jdp::>saJd to asnqe JO asns!w a41 01 palelaJ SI!S!^ 03 sapnpu! sle::>!lna::>eWJe4d to asn le::>!pawuoN 'Ja^o pue ~I: pa6e slua!jed U! auole pasn 1040::>le sapnl::>xa lnq '~I: Japun slua!jed U! auole pasn j040::>le pue s6nJp Ja410 41!M UO!jeU!qwo::> U! pasn j040::>le sapnl::>u! AJ06ale::> 1040::>le a41 'le6all! AlleJaua6 aJe le41 sa::>uelsqns to asn a41 6u!^10^u! SI!S!^ 03 SJa^o::> N06aje::> s6nJp lP!II! a41 'sle::>!lna::>eWJe4d to asn le::>!pawuoN 111I pue '1040::>1\f III 's6nJp lP!1I1 III :sa!J06ale::> aaJ41 6u!MOIIOJ a41 to SWJal U! palUasaJd eJe esnqe pue esns!w 6nJp 41!M pale posse SI!S!^ 03 to salew!jse leuO!leu e41 'esnqe pue esns!w 6nJp 6Ul^10^U! SI!S!^ 03 uo Alpewpd sesn::>ot UO!le::>!Iqnd S!41 'peoJq Ne^ S! NM\fO Aq paJa^o::> SI!S!^ 03 paleleJ-6nJp to AeJJe lint e41 el!4M G.uO!le~!lqnd sllIJ U! paJ,MOO SI JellM ,,'eMq\f pelelnqe110N" JO "\f1N,, uO!je!^aJqqe e41 41!M ajqel e U! 01 peJJetaJ eq Aew s6nJp to dnoJ6 lenp!SaJ e 'suo!jenl!S esa41 ul 'UO!le::>!jqnd S!41 U! s6nJp to sedAllle ue^e JO s6nJp lie M04s 01 elq!ssod IOU S! I! 'Nelnqe::>O^ 6nJp NM\fO e41 U! pepnpu! s6nJp to epnl!llnw e41 01 enp 'uo!l!Ppe ul ,,'peltpeds eS!MJa410 ION" JO "SON" UO!le!^eJqqe e41 41!M SUO!le::>!Iqnd NM\fO U! pelou eJe SUO!lenl!S ese41 'C.sele!do" JO "sau!deze!pozuaq" 'a::>uelSU! JOt) sep06ele::> 6nJp ::>!tpedsuou AIUO sepnpu! pJo::>aJ le::>!pew e41 'sase::> ewos ul DAWN member hospital submitted 1,077 DAWN cases. However, the number of submitted cases varied widely across hospitals, from 7 cases to 6,782 cases (median 820) in a single hospital during 2006. Estimates in this publication Estimates in this publication were calculated by applying sampling weights, non response adjustments, and poststratification adjustments to data from the probability sample of hospitals. Only national estimates pertaining to the entire United States-50 States and the District of Columbia-are provided in this publication. Hospitals eligible for the DAWN sample are non-Federal, short-stay, general medical and surgical hospitals in the United States that operate 24-hour EDs. The American Hospital Association's (AHA) 2001 Annual Survey is the source of the sampling frame. Subsequent AHA surveys are used annually to refresh the sample. For a definition of sampling frame and other technical terms used in this publication, see Appendix B: Glossary of Terms. The DAWN sample of hospitals includes an oversampling of hospitals in selected metropolitan areas (referred to as oversample areas), supplemented with a sample of hospitals from the remainder of the United States, which includes other metropolitan areas, as well as non metropolitan and rural areas. The metropolitan area boundaries correspond to the definitions issued by the Office of Management and Budget (OMB) in June 2003. National estimates are calculated as the sum of the estimates from oversample areas plus the estimate for the remainder of the United States after taking into account non response, the volume of ED visits delivered by the universe of eligible hospitals in each area, and data quality factors. A more detailed discussion of the DAWN sample of hospitals and estimation procedures is provided in Appendix C. Margin of error for estimates Since DAWN relies on a sample of hospitals, each estimate produced from the DAWN ED data is subject to sampling variability, referred to as the "margin of error." This is the variation in the estimate that would be observed naturally if different samples were drawn from the same population using the same procedures. The sampling variability of an estimate in this publication is measured by its relative standard error (RSE). The precision of an estimate is inversely related to its sampling variability, as measured by the RSE: the greater the RSE, the lower the precision. DAWN estimates with RSE values greater than 50% and quantities less than 30 are regarded as too imprecise for publication and are not shown. Three periods ("...") are displayed in the place of suppressed estimates. Ratios (percentages or rates per 1 00,000 population) based on suppressed estimates are likewise suppressed. Gray shading in a cell indicates that the cell is not applicable. For example, drugs other than alcohol cannot be present in an "alcohol-only" category. In this publication, 95% confidence intervals (Cis) are included in many of the tables and are cited in the text along with the estimates. A 95% CI means that if repeated samples were drawn from the same population of hospitals using the same sampling and data collection procedures, the true population value would fall within the confidence interval 95% of the time. A CI, which is expressed as a range of values, is useful because the interval reflects both the estimate and its particular margin of error. DAWN, 2006: NATIONAL ED ESTIMATES 1 5 S31'v'VlIlS3 03 l'v'NOIl'v'N :900l 'NM'v'O 9 ~ '^s:)'v~al!.::J-t1-\fl\fOllV-LOOllS3-JN :all.::J 'llul~'sjaSejePIlS8dod/^06'snSua8MMM/rdll~ :~u!l 'sajew!js3 UO!jelndod AI~jUOV'J 'u!6PO :J!ueds!H pue 'a88J PU8 xas 'a68 )0 maA al6u!s - s:J!lSpap8J8~:J :JI~d8J60wap Aq Saj8W!jSa 18UO!j8N 'jaS8j80 UO!l81ndod 18UO!j8N UO!j8lndod juaPIsatll8sua:JjSOd snsuaJ)o n8aJns 's'n a~j WOJ) '900l/6/9)0 S8 'aJ8 900l JO) Saj8W!jSa UO!l81ndod O~ 'SJ8aA juanbasqns JO Jopd WOJ) aso~j OJ alq8J8dwo:J JOU aJ8 pa~S!lqnd aJaM j8~j Saj8W!jSa a~j PU8 tOOl JO) pa~S!lqnd JOU aJaM Saj8w!lsa J8aA-lIn.::J '(SI8j!dso~)0 aldw8s Plo a~j "6'a) Plo a~j)o awos OSl8 jnq (8paj!J:J aS8:J papu8dxa a~j "6'a) SaJnj8a) Mau a~j)o awos papaliaJ 8j8p COOl :J8aA UOlj!SU8Jj 8 S8M COOl 'NM\fO JO.::J 6 'NMVO 01 paj.JodaJ elep A1P1ULlla pue a::JeJ aLll saqp::Jsap 'NMVO U! 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JaWP leLll sap06ale::> Japua6 pue a6e SSOJ::>e SI!S!^ 0310 suospedwo::> P!le^ a~ew 01 papaau aJe saJnseaw paz!pJepuelS az!s UO!~elndod JOJ pa~snfpe sa~eW!lS3 'SJeaA lUaJawp JO~ salew!lsa uaaMlaq sa::JuaJamp jUe::J!~!u6!s JOl 6u!ISal 10 pOLllaw aLll uo I!elap leuO!I!ppe sap!AOJd J xlpuaddv 'SJeaA OMl aLll uaaMlaq a6ueLl::J leaJ ou seM aJaLllleLll ale::J!pU! lue::>!I!u6!s Alle::>!IS!lelS IOU aJe leLll sa::>uaJawo 'JOJJa 10 u!6Jew aLll paa::>xa lsnw a::>uaJawp aLll 'S! leLll 'lue::J!I!u6!s Alle::J!lS!lelS aq lsnw SJeaA OMl JO~ SaleW!ISa uaaMlaq a:JuaJawp aLll 'a6ueLl::> e se UO!le:J!lqnd S!Lll U! pajJodaJ aq 01 'JOJJa JO u!6Jew Sl! papaa::>xa a::>uaJawp aLll~! ulej.Ja:Jse 01 SJeaA OMl uaaMlaq SaleW!ISa 10 las Ll::Jea palsal slsAleue NMVO SJeaA SSOJ~e suos!Jedwo~ JOJ. JO.ua JO u!6JelJ\l 6'(pJeMJO~ pue POOZ) NMVO pau6!sapaJ aLll pue (SJeaA JO!Jd pue WOZ) NMVO Plo uaaMlaq apew aq louue::> suos!Jedwo::> '11nSaJ e sV 'SpUaJl U! UO!ldnJs!p lUaUewJad e paleaJ::J slUawaAOJdw! asaLl1 'a::>ueJnsse Al!lenb pue 6u!pu!J ase::> JO~ 10::J010Jd aLll pue 'sase::J asaLll uo pall!wqns Swal! elep aLll 'NMVO JOl alq!6!1a sase::> palelaJ-6nJp aLll 'aldwes lel!dsOLl aLll 10 u61sap aLll papnpu! sa6ueLlJ 'SaJnleal aJo::J s,NMVO 10 ISOW paJalle leLll u6!sapaJ e 10 l[nSaJ aLll se €OOZ 10 6U1Uu!6aq aLllle palnl!lsu! aJaM NMVO 01 sa6ueLl::J Jofev.J '900Z JOl asoLll 01 pue POOZ JOJ asoLll 01 900Z JOJ sajew!lsa 6upedwo:J Aq passasse aJe sa6ueLl::> JeaA-UaaMlaq 'UO!le::>!Iqnd S!Lll ul SJeaA SSOJ~e suospedwo:) 'J x!puaddv U! pap!^oJd aJe saldwexa pue suo!ldlJ::>sap leuo!l!ppe 'slda::Juo::> le::>!IS!lelS asaLll Lll!M Je!l!welun sJapeaJ JO::l .. DRUG MISUSE AND ABUSE IN ED VISITS or 2006, DAWN estimates that over 1.7 million ED visits were associated with drug misuse or abuse (Table 1). This estimate includes: III 958,164 ED visits (CI: 690,218 to 1,226,11 O) that involved illicit drugs alone or in combination with other drugs, II 577,521 ED visits (CI: 501,994 to 653,048) that involved the use of alcohol alone or in combination with other drugs, and II 860,108 ED visits (CI: 787,298 to 932,918) associated with nonmedical use of pharmaceuticals alone or in combination with other drugs.11 Of the 1.7 million drug misuse/abuse visits, about two thirds (66%) were associated with a single drug type (illicit drugs, alcohol, or nonmedical use of pharmaceuticals). ED visits involving illicit drugs alone accounted for 31 % of all visits related to drug misuse/abuse in 2006. ED visits involving nonmedical use of pharmaceuticals alone accounted for another 28%. About 7% of drug misuse/abuse visits were related to consumption of alcohol (and no other drug) by a minor.12 The remaining visits (34%) involved some combination of illicit drugs, alcohol, and/or nonmedical use of pharmaceuticals. This does not suggest that the majority of ED drug misuse/abuse visits involved a single drug. In fact, the typical drug-related ED visit involves multiple drugs, but these may be of a common type. For example, an ED visit involving illicit drugs alone often involves more than one illicit drug (e.g., cocaine and heroin). ED visits in each of the three major categories-illicit drugs, alcohol, and nonmedical use of pharmaceuticals- are discussed in greater detail in separate sections of this publication. 11 These three categories of ED visits are not mutually exclusive, and the sum of the estimates is greater than the total number of drug misuse/abuse visits. See Appendix C for additional detail on the type of ED visits included in each category. 12 ED patients over the age of 21 for whom alcohol was the only drug associated with their ED visits are not considered DAWN cases. DAWN, 2006: NATIONAL ED ESTIMATES 17 4 S31lfV'lllS3 03 llfNOlllfN :900Z 'NMlfO 9 ~ '(alepdn Baal/So) gOal '~JOMlaN 6UIUJeM asnqlf 6nJO 'lfSHV'JlfS 'salpnlS pa!lddlf )0 aOI))O :3~l:lnOS 'sa6e lie JO) papnpuI S! 's6nJp Ja~IO ~IIM lUasaJd ua~M 'IO~OOIIf 'sllnpe JO) SI!SI^ "IUO-Io~oole sapnpxa NMlfO t 'salelS pal!Un a~l UI s03 mO~-vl ~IIM Slel!dso~ "els-)Jo~s 'leJapa::l-uoU)O aldwes a^llelUaSaJdaJ e uo paseq SIIS!^ 03 )0 SaleW!ISa aJe asa~l G 'woownllmllMMM/rdn~ Ie laUJalul a~l uo puno) aq ueo pue If xIPuaddlf U! papI^oJd sl UOO!xa7 a~l)o asn 6UIUJa^061uawaaJ61f 6UISUaO!1 wnllnV'J a~l '(LOOl) SluawaJ!nbaJ anblun s,NMlfO laaw 01 pa!IIPow seM uO!leo!llssep a~l 'oul 'SaOIAJas uOllewJolul wnllnV'J 'LOOl cr> 'UOO!xa7 wnllnV'J a~l WOJI pa^pap sl NMlfO uI pasn s6nJp 10 UOlleo!)ISSep a~l 8GO' ~L - 6LO'8v 8'6 %S SIjIj'61j sle:mnaOeWJe4d pue 10400le 41lM s6nJp l!:l!lll 9vn6~ - Ovti:lj~ B'Ij %O~ f;VL'W sleollnaoeWJe4d 41lM 1040011f O~Ij'W - ~91j'W 17'0 ~ %B 1jf;Ij'm sleollnaoeWJe4d 41lM s6nJp 1!:l!1I1 i:~8'LLG - Of;n 9 ~ Ij't~ %U ~i:9'6 ~i: sl0400le ~IIM s6nJp l!:l!lll suolleulqwoJ i:S8' ~ 179 - ~i:L'Of;V 8'9 %8i: 9Lt98v "IUO sleollnaoewJe4d i:v9'm - 99L'96 9D %L VOL'9i: ~ (~i: > 86e) "IUO 104001\1 68 ~ '6GL - 0i:6'tvf; f;'8~ %~f; v99'9f;9 "IUO s6nJp l!:lllll 889'v80'i: - 980' ~9P' ~ 9'8 %OO~ L8S'i:vH asnqe{8SnS!W 6nJp 10 sad"IIlV punoq - punoq (3Stj) JOJJ8 Jaddn JaMol pJepuels S)!S!^ 10 lSIIS!^ ~lu8Wa^10^UI 6nJa a^!leI8tj lU80Jad palewns3 le^J81u! 80uapl1uoJ %96 900~ :}UaWaAIOAU! 6nJp JO €IdA} Aq I's'n alH U! S}!S!A 03 U! asnqe pue asns!w 6nJO ~ alqel I) ILLICIT DRUGS IN ED VISITS o better understand the role of specific drugs and types of drugs in ED visits, this publication provides more detailed analysis of three drug categories: illicit drugs, alcohol, and nonmedical use of pharmaceuticals. This section focuses on ED visits involving illicit drugs. For 2006, DAWN estimates that 958,164 (CI: 690,218 to 1,226,110) ED visits involved an illicit drug (Table 2). Thus, over half (55%) of all the drug misuse/abuse ED visits during the year involved illicit drugs, either alone or in combination with another drug type. DAWN estimates that cocaine was involved in 548,608 (CI: 374,579 to 722,636) ED visits. In other words, close to one in three drug misuse/abuse ED visits (31 %) involved cocaine. Marijuana was involved in 290,563 (CI: 238.737 to 342,388) ED visits. Although it was associated with the second highest number of drug misuse/abuse ED visits for illicit drugs, marijuana was involved in approximately half as many ED visits as cocaine. Heroin was involved in 189.780 (CI: 119,525 to 260,035) ED visits, or approximately 11 % of drug misuse/abuse ED visits overall. This is likely an underestimate, though, because some portion of heroin use has been unavoidably classified as an "unspecified opiate." Heroin is an opiate, and some drug screens test for opiates only as a class. Nearly two thirds (64%) of reports of "opiates" submitted to DAWN for 2006 came from toxicology findings, so some unknown quantity of these may have been heroin. The number of drug misuse/abuse ED visits involving unspecified opiates is estimated at 55,674 (CI: 42,590 to 68.757) visits. Stimulants, including amphetamines and methamphetamine, were involved in 107,575 (CI: 66,105 to 149,046) ED visits, about 6% of drug misuse/abuse ED visits. Amphetamines and methamphetamine are combined for this analysis because some drug screens test for amphetamines only as a class. Consequently, an amphetamine-positive result could indicate amphetamine or methamphetamine. Nearly all (99%) of the reports of amphetamines submitted to DAWN came simply as "amphetamine" and 65% of those were derived from toxicology findings. Other illicit drugs appeared at much lower frequencies. For 2006, DAWN estimates: ill MDMA (Ecstasy) in 16.749 ED visits (CI: 11,470 to 22,028), IIlI PCP in 21,960 ED visits (CI: 5,518 to 38,403), m Miscellaneous hallucinogens in 3,898 ED visits (CI: 2,591 to 5,205), Il.I LSD in 4,002 ED visits (CI: 1,945 to 6,059), I!I GHB in 1,084 ED visits (CI: 517 to 1,652), and !lI Ketamine in 270 ED visits (CI: 29 to 511). DAWN, 2006: NATIONAL ED ESTIMATES 1 9 o S31VVolllS3 a3 lVNOIlVN :900l 'NMVa 0<: EO ~ 't - LOO'~ 0'9(; 9S0'(; (V1N) a^oq8 paj81nq8jjOU SUOlj8U!qwOJ OOV'L - 988'E 6'9~ Ev9'9 SjU8184U\ 90tS - ~69'(; ~"H 868'E sUa60U!8n\l84 snoau8\1a8S!lAJ EOV' 8E - 8~9'9 (;'8E 096' ~(; dJd 690'9 - 9v6' ~ (;9(; GOO'v OSl ~~S - 6(; 9'9v OLG aUIW8ja)j .., - .., ,., (loudA40tj) w8daZ8Jj!Unl:J (;S9' ~ - H9 L'9(; v80' ~ 8H8 6GO'(;(; - OLv' ~ ~ ~ '9 ~ 6v L'9 ~ (AS8jS8:3) VlAJOlAJ v6~'6~~ - E99'Ov ~ 'S(; v(;6'6L aU!W8ja4dw84jalAJ 9W6E - vto'9(; n~ Ovt(;E SaUlW8ja4dwv 9VO'6V~ - 90 ~ '99 L'6~ SLS'LO~ SjU8\nWljS 88nvE - L EL' 8E(; ~'6 E99'06(; 8u8n[IJ8lAJ Sto'09(; - 9(;9'6 ~ ~ 6'8~ 08L'68 ~ U!OJaH 9E9'(;GL - 6L9'v LE (;'9~ 809'8VS aU!880J 0~~'9(;n - 8~t069 n~ v9 ~ '896 s6nJp jP!l1! 'Sj!SI^ 0:3 889'vEO'l - 980' ~9V' ~ 9"8 L88'lvn SI!S!^ 0:3 asnq8/asns!w flnJp IBj01 Sj!S!^ 0:3 paj8\8J-6nJO punoq punoq Jaddn JaMol 18mjU! a8uap!lu08 %96 (:3Stj) JOJJa pJ8pU8jS a^!j8Iatj V'€'lSI!S!^ pajBW!lS:3 ~ sflnJp papalas PU8 ,{JOflajB8 flnJO 900Z :Sl!S!^ 03 u! sBnJp l!:>!I11 Z 81qel (). Table 2 (continued) Illicit drugs in ED visits: 2006 Drug category and selected drugs 1 ED visits Relative per 100,000 standard population2,3,4 error (RSE) ED visits per 100,000 population 95% Confidence interval Lower Upper bound bound Total drug misuse/abuse ED visits 576.7 8.5 480.1 - 673.2 ED visits, illicit drugs 317.0 14.3 228.4 - 405.7 Cocaine 181.5 16.2 123.9 - 239.1 Heroin 62.8 18.9 39.5 - 86.0 Marijuana 96.1 9.1 79.0 - 113.3 Stimulants 35.6 19.7 21.9 - 49.3 Amphetamines 10.7 11.4 8.3 - 13.1 Methamphetamine 26.4 25.1 13.5 - 39.4 MDMA (Ecstasy) 5.5 16.1 3.8 - 7.3 GHB 0.4 26.7 0.2 - 0.5 Flunitrazepam (Rohypnol) ... ... ... - ... Ketamine 0.1 45.6 0.0 - 0.2 LSD 1.3 26.2 0.6 - 2.0 PCP 7.3 38.2 1.8 - 12.7 Miscellaneous hallucinogens 1.3 17.1 0.9 - 1.7 Inhalants 1.9 15.9 1.3 - 2.4 Combinations not tabulated above (NTA) 0.7 26.0 0.3 - 1.0 The classification of drugs used in DAWN is derived from the Multum Lexicon, @ 2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at httpl/wwwmultum.com. 2 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. ED visits often involve multiple drugs. Such visits will appear multiple times in this table (e.g., a visit involving both cocaine and heroin will appear twice in this table). Summing ED visits as reported will produce incorrect and inflated counts of ED visits. 4 Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). When considered in relation to the population of the United States, ED visits associated with illicit drugs vary across major drugs of abuse (Figure 1): III 182 visits per 100,000 population for cocaine, III 96 visits per 100,000 population for marijuana, ill 63 visits per 100,000 population for heroin, and III 36 visits per 100,000 population for stimulants. DAWN, 2006: NATIONAL ED ESTIMATES 21 <J S31lfWI1S3 03 llfNOl1lfN :900Z 'NMlfO zz '(SjUelnW!IS JOt %OZ pue U!OJ84 JOt %8 "6'8) s6nJp 8WOS JOt J84614 seM 86elu8~J8d 841 pue '1IeJ8AO SI!S!A p81e18J-6nJp !P!II! to % ~ ~ UI uMou~un seM ^IP!U418/8~eJ :elep 6u!SS!w ^q P8P8dw! SI sdnoJ6 ^lPIU418/8~eJ 841 SSOJ~e S8pU8nb8Jt 8Aljel8J 841 6u!lenleA8 'J8A8MOH '8114M 8J8M 04M SIU8!led P8AloAUI 8sn 6nJp lPIlIl ^ue 01 P8jel8J Sl!S!^ 841 to %PP '^lPIU418/8~eJ to SWJ81 UI 'pp 01 8 ~ p86e SIU8!led JOt IS846!4 8J8M sluelnw!lS JOt S8jeJ 841 pue 'PZ 018 ~ p86e Slu8!led JOt IS846!4 8J8M euenfpew JOt S81eJ 841 8114M 'pg 01 ~Z p86e SIU8!led JOt IS84614 8J8M S81eJ 841 'U!OJ84 JO:l ,(Z 8Jn6!:I '€ 81qe1) SIU8!led J8PI0 pue J86uno^ JOt S81eJ J8MOI 41!M 'pg 018 ~ p86e SIU8!led 6uowe IS846!4 8J8M UO!lelndod 000'00 ~ J8d S81eJ 841 8U!e~0~ JO:l ,(Z 8Jn61:1) slUelnW!lS JOt 8~U8J8JJ!P J8pU86 e IOU seM 8J8411nq 'luno~~e OIU! JOJJ8 to u!6Jew 841 pue 8Z!S UO!lelndod 6ul~el J8ye 'S81eW8t JOt ue41 S81eW JOt J84614 8J8M UIOJ84 pue 'euen[uew '8U!e~0~ 6U!AIOAU! SlIS!^ 03 to S81eJ 841 '(al8pdn 800<:/\:0) 900<: '~JOMlaN 6U!UJ8M asnqlf 5nJO 'lfSH~VS 'Sa!pnIS pallddV )0 a:JIJJO :3:)cInOS sluelnwI1S U!OJaH euen!ueV\l au!eJO) o os ~ '" <:J ~ o o OOL C, o o <:J o <:J C ~ OSL 0' :::> laL OOl 900Z :s6nJp lP!1I! pal::lalaS 6U!^IO^U! Sl!S!^ G3l0 Sale~ ~ 8m6!:l 11 Table 3 Illicit drugs, by patient characteristics: 2006 Patient characteristics All illicits Selected drugs 1 PCP Drug-related ED visits2,3 ED visits, illicit 958,164 548,608 189,780 290,563 107,575 16,749 1,084 4,002 21,960 drugs Gender Male 631,052 354,268 129,914 195,063 68,638 10,835 824 3,297 15,298 Female 326,846 194,121 59,7 44 95,478 38,930 5,915 261 705 6,661 Unknown 266 ... ... ... ... ... ... ... ... Age 0-5 years 855 585 ... ... ... ... ... ... ... 6-11 years ... ... ... ... ... ... ... ... ... 12-17 years 58,428 10,984 1,661 44,088 7,740 4,524 ... 1,045 1,242 18-20 years 71,973 26,802 8,299 44,146 8,487 3,997 ... 1,075 1,718 21-24 years 105,043 47,515 17,119 46,388 16,453 4,217 ... 611 5,118 25-29 years 126,699 63,945 26,607 42,626 20,489 1,928 121 ... 5,637 30-34 years 107,718 67,820 23,657 28,904 15,000 1,124 175 ... 2,714 35-44 years 264,430 181,912 57,155 49,571 26,170 417 ... ... 3,088 45-54 years 176,026 122,028 42,662 26,367 10,068 ... ... ... 2,271 55-64 years 39,767 23,177 11,049 6,947 2,680 ... ... ... ... 65 years and 5,929 3,499 1,456 1,071 older ... ... ... ... ... Unknown 388 300 ... 68 ... ... ... ... ... Race/ethnicity White 421,775 215,718 78,470 154,081 57,582 8,140 720 2,898 6,087 Black 295,041 213,797 49,522 75,835 6,638 4,392 ... ... ... Hispanic 126,529 63,692 35,781 31,528 ... 1,528 ... ... ... Racelethnicity not tabulated 7,830 3,206 1,656 1,871 1,893 90 ... ... ... above (NT A) Unknown 106,990 52,194 24,351 27,248 21,658 ... 130 ... 1,625 DAWN, 2006: NATIONAL ED ESTIMATES 23 t[ S3111V'JIlS3 03 lllNOI111N :9001: 'NMIIO vi: '(818pdn 900l1EO) gOal '~JOMI8N 6UIUJ8M 8snqll 6nJO 'IISHVIJIJS 'S8ipnlS p8!1ddll )0 801))0 :3~~nos 'p8SS8Jddns U88q S84 OE U841 SS81818W!lS8 U8 JO %Og U841 J8188J6 3Sl:l U8 41iM 818W!lS8 U8 18418180lPUI (..,) SlOP 88J41 t 'S8181S p81!Un 841 uI s03 Jn04-vl 41!M SI81idS04 A81S-jJ04S '18J8p8j-UOU )0 81dw8S 8^i181U8S8Jd8J 8 UO p8S8q SIIS!^ 03)0 S818W!lS8 8J8 8S841 'wonW1111l11.lMMM/rd1l418 18UJ81UI841 uo puno) 8q U80 PU8 II XiPU8ddv uI P8P!^oJd sl UOO!X87 841)0 8sn 6UiUJ8^061U8W88J6v 6U!SU80il wnllnV\j 841 '(LOOl) S1U8W8Jlnb8J 8nb!un s,NMVO 188W 01 P81)!POW S8M UO!180!)ISS8P 841 'oul 'S80!fU8S UOI18WJO)UI wnllnV\j 'LOOl @ 'UOO!X87 wnllnV\j 841 WOJ) P8^P8P SI NMVO ui p8sn s6nJp)0 UO!180I)!SS8P 841 ~ .., .., ,.. .., .., In: 9'f: l'6 g~ J8PIO PU8 SJ88^ gg .., ,.. ,.. .., {9 nl Ht: S'OL ~nl~ SJe8^ v9-gg l'g .., .., .., 6'll 0'09 ~L6 S'LLl L'OOv SJe8^ vg-gv ~L .., .., 0' ~ v09 g'v~ ~ om ~'Olv L'O~9 SJe8^ vv-gt: sn ,.. 60 g t:'9L ~m v'Ol~ O'gvt: O'Svg SJe8^ Vt:-Ot: 9'9l .., 9'0 ~ '6 g'96 600l vgl~ t: ~Ot: O'L6g SJe8^ 6l-gl ~ 'ot: 9't: .., 8'Vl 6'96 l'Ul S'OO~ 6'6Ll L'S~9 SJe8^ vl- ~l 9't:~ g'S .., g' ~t: OL9 t:SVt: g'g9 n~l 6'L9g SJe8^ Ol-S ~ 6'17 ~'v '" S'H vot: nH g'9 l't:v 9'6ll SJe8^ L~-l~ ,.. .., .., .., ,.. ,.. .., .., .., SJe8^ ~ ~-9 .., .., .., .., .., .., ,.. vl g't: SJe8^ g-O 85V €'V g'O (O 6t: v'gl €'l9 O'6t: L'9l ~ n~l 81ew8,j t:'O ~ l'l 9'0 €'L ~'9v 6'Ot:~ l'LS S'Lt:l g't:lv 81eV\j J8pU88 '?,'L n v'o g'g 9'g'?, r96 8'l9 9'~8~ O'H'?, s5nJp liO!!I! 'SI!S!^ 03 d~d SI!O!II! IIV SO!ISp810eJB40 IU8nBd 900l :s:>nSpalOBJBl(:) luanBd Aq 's6nJp ~!O!lll (panU!+UOJ) € elqel Figure 2 Illicit drugs, ED visit rates by age and gender: 2006 Cocaine 500 c 500 c 420 0 .9 'p ;0 '" 400 400 :; :; Q. Q. 0 0 Q. Q. 0 300 0 300 238 0 0 0 0 6 0' ~ 200 ~ 200 Q; Q; 127 Q. Q. r--, ~ 100 ~ 100 '" '" '" '" 0 0 ""' 0 """ '" """ """ """ "" + Male Female 6 N ":" N M "" ""' <0 ""' ..0 N cO J., 6 J., J., J., <0 N N M M """ ""' Marijuana 500 500 c c 0 ,g 'p '" 400 '" 400 :; 348 :; Q. Q. 0 0 Q. Q. 0 300 0 300 0 0 0 0 6 6 ~ 200 ~ 200 131 Q; Q; Q. 100 Q. 100 ~ ~ '" m '" '" 0 0 ""' r-- 0 """ '" """ "" """ """ + Male Female 6 ":" ":" N M "" ""' <0 ""' ..0 N ~ J., 6 J., J., J., <0 N N M M """ ""' Heroin 500 c 500 c 0 0 .~ 'p 400 '" 400 :; :; Q. Q. 0 0 Q. Q. 0 300 0 300 0 0 0 0 6 6 ~ 200 ~ 200 Q; Q; Q. Q. 87 ~ 100 ~ 100 '" m 39 '" 4 '" 0 0 r~~~"J u;' r-- 0 "" '" """ """ "" """ + Male Female N ":" N M """ ""' ~ ""' 0 ..0 N cO J., 6 J., J., <0 N N M M """ ""' Stimulants 500 500 c c .9 .9 ;0 400 ~ 400 :; Q. Q. 0 0 Q. Q. 0 300 0 300 0 0 0 0 6 0' ~ 200 ~ 200 Q; 97 97 Q; Q. Q. ~ 100 ~ 100 46 '" '" 25 '" '" 0 0 ~'."'1 ""' r-- 0 """ '" """ """ """ """ + Male Female 6 '" N ":" N M """ ""' <0 ""' N cO J., 6 J., J., J., <0 N N M M """ ""' SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 25 o 26 DAWN, 2006: NATIONAL ED ESTIMATES o o o 'l- ALCOHOL IN ED VISITS mong all the drugs collected by DAWN, alcohol is unique. An ED visit related to alcohol use qualifies as a DAWN case under only two conditions: (1) the alcohol is found in combination with other drugs, regardless of patient age; or (2) the alcohol is found alone (i.e., not in combination with other drugs) in a patient under the age of 21. ED visits associated with alcohol use, particularly among underage patients, represent a significant public health and policy concern and are examined in detail in this section. For 2006, DAWN estimates that 577,521 (CI: 501,994 to 653,048) ED visits involved either alcohol in combination with another drug (all ages) or alcohol alone for patients under the age of 21. This is about one third (33%) of all drug misuse/abuse ED visits (Table 4). Of all these ED visits involving alcohol, about one fifth (22%) involved patients under the age of 21 who used alcohol alone, that is, with no other drug. Table 4 Alcohol in drug-related ED visits: 2006 Relative 95% Confidence interval Drug category and selected drugs 1 Estimated standard visits2,3 Lower Upper error (RSE) bound - bound Total drug misuse/abuse ED visits 1,742,887 8.5 1,451,086 - 2,034,688 ED visits, alcohol 577,521 6.7 501,994 - 653,048 Alcohol in combination 450,817 7.6 383,818 - 517,816 Alcohol alone 126,704 12.5 95,766 - 157,642 1 The classification of drugs used in DAWN is derived from the Multum Lexicon, @2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at http://www.multum.com. 2 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. 3 Estimates are all expressed in visits. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network. 2006 (03/2008 update). Alcohol in combination with other drugs (Tables 5-6, Figure 3) DAWN estimates 450,817 (CI: 383,818 to 517,816) ED visits related to use of alcohol in combination with another drug(s) in 2006. Alcohol in combination with other drugs is reported to DAWN regardless of the patient's age. These are the only alcohol reports received for patients aged 21 and older. It is these adult patients who account for nearly 9 out of 10 ED visits (87%) implicating alcohol with another drug (Table 5). Males accounted for 63% of visits involving alcohol in combination with other drugs (Table 5). Taking population size and the margin of error into account, males had higher rates of such visits than females (Figure 3). There was little variation in rates across the age groups from ages 18 to 54. ED visit rates were lower for older and younger patients. DAWN, 2006: NATIONAL ED ESTIMATES 27 II S31lfv.l11S3 03 llfNOlllfN :900l 'NMlfO 8Z '(ajepdn 900llEO) 900G '~JoMjaN 6u!UJeM asnqlf 6nJO 'lfSHV<JlfS 'sa!pnjS pa!lddlf )0 a:J!JJO :3::>~(10S 'passaJddns uaaq se4 OE ue4j ssal ajewljsa ue JO %Og ue4j JajeaJ6 3S~ ue 4j!M ajew!jsa ue je4j aje:J!pu! (..,) SjOp aaJ41 l 'sajejS paj!u(1 a4j U! s03 m04-vG 4j!M Slej!ds04 AejS-jJ04S 'l8Japa:l-UOU )0 aldwes aA!jejuasaJdaJ e uo paseq Sj!S!A 03 )0 sajew!jsa aJe asa41 ~ v6E'\7\7 UMOU~U(1 ~6L'l LL6'9 g~6'Ov gvO'~9 ~WLg SgS' 617 m'l~ 6lv v L j7'gt: SOL'gg ~ m'gl vgg'g~ v~~'m ~90'vEl L~S'Ogv LWOgv nSI!S!A pajBWnS3 017tv ('V1N) aAoqB p8jBlnqBjjOU Aj!0!U4j8/80B~ o!uBds!H ~oB18 8j!4M Aj!0!U4ja/aoB~ UMOU~U (1 J8PI0 pUB SJe8A gg SJB8A vg-gg SJB8A 17g-g17 SJB8A v17-gt: SJB8A Vt:-Ot: SJB8A 6l-gl SJeaA 17l- ~l SJB8A Ol-S ~ SJB8A n-l~ SJB8A ~ ~-g SJeaA g-O a6'V p81U8wnoop ION J8410 P810 80lApB leolp8W jsu!e5e U8l p8JJ8)SUeJl uOIj!sods!p J8410 Ilun lua!ledu! J8410 I!un 0IJIB!40ASd XOI8P/AOU8PU8d8P leo!W84J AJ85ms 8JeO leO!I!Jof(1JI lel!ds04 S!41 01 p8ll!wp'V IU8WIB8JI/XOI8P 01 p8JJ8)8tj I!Bf/80!IOd 01 p8SB818tj 8w04 pa5JB40S!0 9LO'~g t:OO'g6 170 ~ '9gl gn t:g\7'L g ~6' ~l SLO'SS 6SV't:t: ~ 170t:'\7V 9t:6't:g v~6'17v wL'~t: SW17l p8SB81aJ pUB palBaJl UO!I!sods!O PSAIOAU! 104001'1 s5nJp 8Id!llnV<J 5nJp SI5u!S paAlo^u! s5nJP!0 J8qwnN SLt99 ~ glV'VSl UMOU~U(1 81Bw8::! 81BV<J JSPUS8 UO!jBU!qwoo U! 10400lB 'Sj!S!^ 03 L~B'Og17 sonSpSjOBJB40 j!S!^ nSj!S!^ pajBw!jS3 SO!jSpapBJB40 juanBd 900(; :s:mSp9l0BJB40 l!S!^ pUB lU9nBd Aq 'UOnBU!qWOO U! I0400lV g 91qel 'UMou~un seM A1P!U41a/80eJ SI!S!^ JO %0 ~ U! :elep 5u!ss!w Aq P8P8dw! S! sdnoJ5 A1P!U418/80eJ 841 SSOJoe S8!OU8nb8JJ 8^!leI8J 841 5u!lenle^3 '81!4M 8J8M 04M SIU8!led P8^10^U! UO!leU!qwoo U! 10400le 41!M SI!S!^ 841 JO %L9 'A1P!U418/8oeJ JO SWJ81 ul Figure 3 Alcohol with other drugs, ED visit rates by age and gender: 2006 350 300 c o '" 250 -s Cl. o ::; 200 o o ~ 150 Q:; Cl. 2! 100 '" ex: 50 350 308 1.,1 1200 jil , i I 167 i 300 o o c o .~ 250 -S Cl. o ::; 200 o o ~ 150 01 Cl. 2! 100 '" ex: 50 Lf"'l r--. 0 '<::j" en "T ~ oe::t' 'O;;j'" + 6 ~ N ~ ~ ~ 6 ~ ~ ~ ~ NNMM~lJ"'l Male Female SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). Alcohol was most frequently combined with (Table 6): li Cocaine alone (101,588 visits), II Marijuana alone (41,653 visits), lIil Cocaine and marijuana (21,241 visits), and II Heroin alone (14,958 visits) Table 6 Drugs most frequently reported with alcohol: 2006 Drugs reported with alcohol1 No other drug Cocaine only Marijuana only Cocaine and marijuana only Heroin only Stimulants only Alprazolam only Cocaine and heroin only 1 Estimated visits2 126,704 101,588 41,653 21,241 14,958 7,895 8,007 10,628 The classification of drugs used in DAWN is derived from the Multum Lexicon, @ 2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at http://www.multulllcom. These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update), DAWN, 2006: NATIONAL ED ESTIMATES 29 # S31V~IlS3 a3 lVNOl1VN :900Z 'NMVa 08 '(v aJn6!.:!) sajeJ Jellwls pe4 sajewaJ pue saleVlj '(000'00 ~ Jad vOZ) L ~ OJ Z ~ pa6e sjuaned JOJ je4j saWn B'G seM (uO!jelndod 000'00 ~ Jad Sj!S!^ ~ gg) OZ OJ 9 ~ pa6e sjua!jed JOJ Sj!S!^ 03 AIUO-1040:)le asa4j JO ajeJ a4j 'juno::l::le OjU! az!s UO!lelndod 6u!~el '(g alqel) weJ60Jd juawjeaJj asnqe a::luejsqns JO xOjap OJ UO!ss!wpe JOJ jsanbaJ e JO jdwalle apP!ns e Ja4j!a OJ pajelaJ JOU seM je4j 6u!~upp a6eJapun juasaJdaJ Sj!S!^ aS04j JO (Sj!S!^ ggg'9Z ~ JO '%66) lie ApeaN '(v alqel) ~Z a6e ue4j Ja6UnOA aJaM 04M sjua!jed Aq (6nJp Ja4jOUe 4j!M uO!jeu!qwo::l U! JOU "a'!) auole 1040::lle JO asn OJ pajelaJ Sj!S!^ 03 (Zv9'L9~ OJ 99L'96 :18) VOL'9U sajew!jsa NM\fO '900Z JO:! (17 amG!.:l 'g '17 salQel) asn IOllO:>le aGeJapun JOl Sl!S!^ 03 vvt7v6 Z09'f:9 ~ 'v ~ tL6'f:L ~ ~tLf: f:6~'9Z 6'B ZOnf: f:69'm L9L'ZB ~ ' ~ ~ 9L9'90~ OZ-B ~ peBe slueqed 09f:'L9 f:Zf:'Lf: 9'17 ~ ZVf:'Z9 f:OL'BZ Vf:~'OZ 0'6 B ~ t7VZ ZOtf:6 B~f:'09 6'O~ 09L'9L L~-U peBe SIUe!led punoq punoq (3SCl) JOJJa Jaddn JaMol pJepuejs zSj!S!^ a^!lelaCl pajew!ls3 le^JajU! aouap!Juo:) %96 '(81epdn BOOl/to) 900l '~JOMI8N OUIUJeM 8snQlf onJO 'IfSH\^JlfS 'S8!pnlS p8!1ddlf JO 80!JJO :3::JClnOS 's81elS pal!Un 841 U! s03 Jn04-vl 41!M Slel!ds04 AelS-jJ04S 'leJ8p8::J-UOu )0 81dwes 8^!lelu8SaJd8J e uo paseq SI!S!^ 03 JO s81ew!ISa 8Je 8sa41 1: 'WOO uII11lnw MMM/ld1l4 Ie 18UJ8jUI 841 uo punoJ 8q ueo pue V XIPuaddlf U! pap!^oJd S! UOO!X87 841)0 8sn OUIUJ8^OOluawa8JOIf OU!SU80!l wnlln\^J 841 '(LOOl) SIU8W8J!nb8J anb!un S,NMlfO 188W 01 P8!J!POW seM UO!leO!J!ssep 841 'oul 'SaO!AJ8S uOllewJoJul wnlln\^J 'LOOl @ 'UOO!Xi37 wnlln\^J a41 WOJJ pa^p8p S! NMlfO UI p8sn SonJp JO UOlleo!J!ssep 841 ~ auole 104001\7' uO!jeu!qwoo uI 104001\7' 10400le 'Sj!S!^ 03 8uole 104001\7' uO!jeu!qwo::l U! 104001\7' 10400le 'SI!S!^ 03 ~ sBnJp papelas pue AJoBejeo BnJO 900l : ~l a6e J8pUn SIU8!led U! SI!S!^ 03 p8lel8J-6nJp U! IOLlO:>I'v' L 81qel '(L alqel) OZ OJ g~ pa6e sjUaned pue U OJ U pa6e sjua!jed JOJ Jel!w!s S! je4j 6u!pu!J e 'auole 1040::lle pa^lo^u! SJOU!W JOJ Sj!S!^ 03 pajelaJ-1040::lle a4j JO (%69) 0 ~ U! L ApeaN 'OZ OJ 9 ~ pa6e Sjuaned JOJ Sj!S!^ 03 pajeWl040::lle (f:69'9U OJ L9L'G9 :18) 9L9'90 ~ 11II pue 'L ~ OJ Z ~ pa6e sjUaned JOJ Sj!S!^ 03 pajeWl040::lle (ZOn6 OJ 9 ~ f:'09 :18) 09L'9L III :sajeW!jsa NM\fO 's6nJp Ja4jO 4j!M UOneu!qwO::l U! 1040::lle pue auole 1040::lle 6upap!SU08 'dnoJ6 a6e S!4j JOJ NM \f0 OJ pajJodaJ aJe uOljeu!qwo::l U! 1040:)/e pue auole 1040::l/e 4joq OJ pajelaJ Sj!S!^ 03 pue '6nJp le6all! ue sl 1040::lle '~Z a6e Japun slenp!^!pu! JO.:l (L alqel) ~Z lO aGe alll Japun swaned U! Sl!S!^ 03 palelaJ-lollo:>I'v' In terms of racelethnicity, 58% of these alcohol-only visits involved patients who were white. Evaluating the relative frequencies of the racelethnicity groups is impeded by missing data; in 16% of visits, racelethnicity was unknown (Table 8). Most (90%) of the alcohol-only ED visits resulted in patients' being treated and released, usually to home; another 6% were admitted to inpatient units (Table 8). Table 8 Alcohol only (age < 21), by patient and visit characteristics: 2006 Patient characteristics Estimated Visit characteristics Estimated visits1,2 visits1,2 ED visits, alcohol only (age < 21)3 125,888 Gender Number of drugs involved Male 71,306 Single drug 125,888 Female 54,574 Multiple drugs Unknown Alcohol involved 125,888 Age Disposition 0-5 years Treated and released 112,671 6-11 years Discharged home 102,839 12-17 years 51,901 Released to police/jail 7,870 18-20 years 73,598 Referred to detox/treatment 1,962 21-24 years Admitted to this hospital 7,479 25-29 years ICU/critical care 1,123 30-34 years Surgery 90 35-44 years Chemical dependency/detox 45-54 years Psychiatric unit 943 55-64 years Other inpatient unit 5,197 65 years and older Other disposition 5,738 Unknown Transferred 3,506 Race/ethnicity Left against medical advice 688 White 73,624 Died Black 7,427 Other 1,032 Hispanic 23,602 Not documented 501 Race/ethnicity not tabulated above 1,709 (NTA) Unknown 19,526 1 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. This table is limited to ED visits classified as "alcohol only (age < 21)" and excludes visits classified as either "suicide attempt" or "seeking detox." Therefore, the estimate of total visits is slightly lower than reported in Table 4. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 31 S31VWI1S3 03 lVNOIlVN :900l 'NMVO Z:€ '(aj8pdn 800Z/tO) 900Z '~JOMlaN 6UIUJ8M asnqv 6nJO 'VSH~VS 'salpnlS pallddV jO a~!jjO :3:)~nOS alewa~ ale~ 0 001 ;;>:J ~ 19l ro DOL ~ 0 0 OOE g 0 -0 0 -0 DOt? ~ 0' ::l OOS 009 V1 .l:> w W N N m V1 V1 V1 0 V1 00 ~ ~ V1 '" U, .f,. W N N N 0 + .l:> .l:> .l:> .l:> <.D .l:> 0 ..... v, 0 DOl ;;>:J ~ ro DOL ~ o o ODE g o -0 o -0 OOt? "'- ~ 0' ::l ODS 009 900Z :Japua6 pue a6e Aq SaleJ l!S!^ 03 '( ~Z > a6e) AIUO 1040:>1'1 V aJn6!:1 .. NONMEDICAL USE OF PHARMACEUTICALS se of illicit drugs is, by definition, substance abuse. For pharmaceuticals, however, distinguishing medical from nonmedical use is more complicated.13In DAWN, "medical use" means taking a prescription or over-the- counter (OTC) pharmaceutical as prescribed or recommended, and "nonmedical use" is use that does not meet the definition of medical use.14 Thus, nonmedical use of pharmaceuticals includes taking more than the prescribed dose of a prescription pharmaceutical or more than the recommended dose of an OTC pharmaceutical or supplement; taking a pharmaceutical prescribed for another individual; deliberate poisoning with a pharmaceutical by another person; and documented misuse or abuse of a prescription or OTC pharmaceutical or dietary supplement. Nonmedical use of pharmaceuticals may involve pharmaceuticals alone or pharmaceuticals in combination with illicit drugs or alcohol. A cautionary note: DAWN tries to capture only drugs that are related to the ED visit and actively discourages reporting of current medications that are unrelated to the visit. It is important to understand, however, that it is not possible, given the limitations of medical record documentation, to eliminate completely the reporting of current medications, and this should be considered when one interprets these findings. Also, it is not possible to know, based on the documentation available in ED medical records, the extent to which pharmaceuticals came from legitimate prescriptions versus other sources. Nonmedical use of pharmaceuticals (Tables 9-10, Figure 5) For 2006, DAWN estimates that 741,425 (Cl: 674,198 to 808,652) ED visits involved nonmedical use of prescription or OTC pharmaceuticals or dietary supplements (Table 9). The majority of these visits (54%) involved multiple drugs (Table 10): IIlI Approximately one fifth (19%) of all nonmedical-use ED visits involved alcohol, III One fifth (21%) involved pharmaceuticals in combination with an illicit drug, and III About 6% involved pharmaceuticals in combination with both alcohol and an illicit drug. Central nervous system (CNS) agents (50% of nonmedical-use visits) and psychotherapeutic agents (44%) were the most frequent drugs reported in the nonmedical-use category of ED visits (Table 9). Respiratory agents (4%), cardiovascular agents (5%), and all other types of pharmaceuticals were much less frequent. Among the eNS agents, the most frequent drugs were opiate/opioid analgesics (33% of nonmedical-use visits), including single-ingredient formulations (e.g., oxycodone) and combination forms (e.g., hydrocodone with acetaminophen). Methadone, together with single-ingredient and combination forms of oxycodone and hydrocodone, were the most frequent opioids. Once the margin of error is taken into account, these three opioids appeared in similar numbers of visits: 13 DAWN cases are identified through a retrospective review of medical charts. Given the limitations of medical record documentation, we have concluded that distinguishing misuse from abuse reliably is not feasible. 14 Taking less than the prescribed or recommended dose is not considered "nonmedical use." DAWN, 2006: NATIONAL ED ESTIMATES 33 " S31V~IlS3 03 lVNOI1VN :900Z 'NMVO 178 vQl7'8 - OS6 rs(; m'(; ajeplUa4dlA4jal^J .., - .., .., .., aU!Weja4dweoJjxao g08'9 - 60g'(; 0'(;(; LOn au!aJJe::J LL9'L - LL8'(; 6'9(; LW'g aU!Weja4dweoJjxap-aU!Weja4dw\f 8S8'S ~ - ~ QI7' 6 g'9~ (;6S'8 ~ sjUelnw!ls SN::J m'v - ~09'(; g'v~ 6(;9'8 SON SOljoudA4 pue 'sa^!jepas 'SO!jAIOIXU\f (;SS'(;(; - 889' ~ ~ 99~ LgtH wap!dlOZ 909'8 - 6vn L'H SL9'(; aUIZAXOJpAH 686'v~ - 8v9'6 o ~ ~ ~6t(;~ au!WeJpA4Ua4d!0 Lv6'Sv - v08'(;8 g'O~ 9(;9'OV SO!jOUdA4 pue 'sa^!jepas 'SO!jAIO!XUe 'OSIl^J 0(; ~ '8s - gLg'88 n(; Sv8'Sg SON sau!daze!pozuaS ~98'S(; - 6LO'6 ~ O'O~ OU8(; wedazeJOl v9L'8(; - so ~ '9 ~ S'6 986'6 ~ wedaze!o v8g' ~ v - OSg'g(; ~(; ~ Lgg'88 wedazeuol::J ~9g'6L - ~ ~6'Og n~ 98tg9 WeIOZeJdl\f ~9n(;(; - 6SL' L9 ~ U g(;9'g6 ~ sauldazelpozuas 8~6'V~ - S90'L rs~ ~ 66' 0 ~ sajeJnj!qJeS LW09(; - v6tLO(; Sg gLS'88(; SO!jOUdA4 pue 'sa^!jepas 'SO!lAIO!XU\f LS8'(;g - OSO'L8 L'B 88L'vv SO!j040ASdljU\f SLL' ~ ~ - vvn g'S(; ~9g'L SjuessaJdap!jue snoauellaosll^J gst(;(; - vWO~ 9'H v9g'9 ~ SjuessaJdap!lue O!lOAOPl ~6V'gv - Svtg(; 9v~ OLE'gE SjuessaJdap!jue IClSS .., - .., .., .., SJOj!qI4U! O\fl^J SEn6 - 9(;0'99 L'B (;S9'6L sjuessaJdapljU\f vOg'OgE - g6V'L6(; n 666'8(;E SlN38\f ::Jlln3d\fCl3HlOHJASd 199'SOS - S6~'vL9 g'v glV' ~ vL asn leO!paWuou 'Sj!S!^ 03 punoq - punoq (3SCl) Jom Jaddn JaMol pJepuejs H,zSj!S!^ ~ s6nJp pajoalaS pue sapo6ajeo 6nJp pajoalas a^!lelaCl pajew!ls3 le^Jaju! aouap!Juo:) %g6 900l :SIB:mnaOBWJB4d 10 asn IBOlpawuoN 6 alqel '(6Sf:'P9 OJ OLS'9f: :18) Sj!S!^ 03 Of: ~ '9P U! 8uopel.Jj8lt\j l1li pue '(Of:O'OS Oj9PL'6P :18) Sj!S!^ 03 SSS'P9 U! suo!leu!qwo::J/8UOPO::JAXQ III '(S6nL OJ ~OL'tP :18) Sj!S!^ 03 099'L9 U! suo!jeu!qwo::J/8UOPO::>OJpAH III Table 9 (continued) Nonmedical use of pharmaceuticals: 2006 Relative 95% Confidence interval Estimated Selected drug categories and selected drugs 1 visits2,3,4 standard Lower Upper error (RSE) bound - bound CENTRAL NERVOUS SYSTEM AGENTS 373,138 5.4 333,720 - 412,556 Analgesics 323,579 5.5 288,441 - 358,717 Antimigraine agents 1,191 29.2 509 - 1,873 Cox-2 inhibitors ... 68.9 ... - ... Opiates/opioids 247,669 6.9 214,160 - 281,177 Opiates/opioids, unspecified 50,978 12.6 38,416 - 63,540 Narcotic analgesics 201,280 8.2 168,954 - 233,606 Bu pren orph i net co m bi n ati ons 4,440 41.6 823 - 8,057 Codeine/combinations 6,928 18.4 4,433 - 9,424 Fentanyl/combinations 16,012 27.3 7,441 - 24,583 H yd rocod one/ co m b in atio ns 57,550 12.3 43,701 - 71,398 Hyd romorphone/combi nations 6,780 23.6 3,649 - 9,911 Meperidi ne/combinations 1,440 38.7 349 - 2,532 Methadone 45,130 10.5 35,870 - 54,389 Morphine/combinations 20,416 14.2 14,750 - 26,082 Oxycodone/combi nations 64,888 11.9 49,746 - 80,030 P ropoxyph ene/ com bi n ati ons 6,220 18.6 3,955 - 8,485 Nonsteroidal anti-inflammatory agents 27,662 8.9 22,846 - 32,479 I bu profen 20,541 8.6 17,071 - 24,011 Naproxen 6,651 17.9 4,314 - 8,987 S al icyl ates/ combi n ati ons 10,399 14.5 7,444 - 13,354 Miscellaneous analgesics/combinations 54,313 7.9 45,938 - 62,687 Acetaminophen/combinations 44,314 9.0 36,482 - 52,146 Tramadol/combinations 6,048 16.2 4,128 - 7,969 Tramadol 5,961 16.4 4,050 - 7,873 Acetaminophen-tramadol ... ... ... - ... Analgesic combinations not tabulated above (NTA) 898 30.8 355 - 1,441 Anorexiants 1,168 28.2 522 - 1,815 Anticonvulsants 31,169 13.2 23,099 - 39,238 Antiemetic/antivertigo agents 1,360 32.6 491 - 2,230 Anti-Parkinson agents 3,816 31.5 1,457 - 6,174 General anesthetics ... ... ... - ... DAWN, 2006: NATIONAL ED ESTIMATES 35 . S31VWIlS3 03 lVNOllVN :900Z 'NMVO 98 '(ejepdn Baal/SO) 900l '~JoMjeN 6u!UJeM esnqlf 6nJO VSHV'JlfS 'se!pnjS pe!lddlf )0 e:JI))O :3:nInOS -pesseJddns ueeq se4 os ue4j sse I ejew!lse ue JO %Og ue4j JejeeJ6 3SCJ ue 4jlM ejeWljSe ue je4j eje:JIPuI (",) SjOp eeJ41 V 'Sj!S!^ 03)0 sjuno:J pejelJUI pue peJJo:JuI e:JnpoJd II!M pejJodeJ se Sj!S!^ 03 6ulwwns '(elqej SI4j uI e:JIMj Jeedde 111M euopo:JOJPA4 pue euopO:JAXO 6UI^IO^UI jIS!^ e "6'e) elqej SI4j U! sew!j eld!llnW Jeedde 111M Sj!S!^ 4:Jns 's6nJp eld!jlnW e^lo^uI uelJo SjISI^ 03 C 'sejejS pej!Un e4j U! s03 Jn04-Yl 4jlM SIejlds04 AejS-jJ04S 'leJepe.::l-uou )0 eldwes e^!jejueseJdeJ e uo peseq Sj!S!^ 03 )0 sejewljse eJe ese41 G 'lUOn1ll1I1nw'MMM/j:dn4je jeuJejUI e4j uo puno) eq ue:J pue If x!pueddlf uI pepI^oJd sl uO:J!xe7 e4j)0 esn 6UIUJe^06jueweeJ61f 6uIsue:J!1 wnjlnV'J e41 '(LOOl) sjUeWeJlnbeJ enb!un S,NMlfO jeew OJ pel)IPOW seM uOlje:J!)lssep e41 ':Jul 'se:JINes uOljewJO)UI wnjlnV'J 'LOOl (2) 'uoJ!xe7 wnjlnV'J e4j WOJ) pe^pep sl NMlfO U! pesn s6nJp)0 UOlje:JI)!SSep e41 LLS'OZ - 669 't ~ L'O~ 8St' H 'r/ 1N sjue6e Jeln:Jse^O!pJeJ 9v~'L - 090 't VOZ W~'9 s:JljeJn!O L06'9 - 9v9't v'9~ at9 sjue6e 6u!>i:JOlq leuue4:J wnpleJ ~L9'9 ~ - 88L'9 9' ~z 6U~~ sIue6e 6u!>i:JOIQ :J!6JeueJpe-ejes 99~'9 - 99ft n~ 0~8'v 6u!pe AlleJjUe:J 'sjue6e :J16JeueJpe!lulf v6ttv - ~6S'6Z 8'6 tvt'9S SlN381f CJ'r/lnJSlfAOIOtJlfJ z98'9 - OVL'Z 9'8~ 96tv If 1N sjue6e AJOleJ!dsetJ 089'8 ~ - 099' ~ ~ O'z ~ 9 ~ ~ '9 ~ SUOljeuIQwO:J AJOjeJldseJ Jeddn S9t't - L88 Hz m'z SjUeJOI:Jedx3 8zV'z - S69 0' ~S ~ ~9' ~ sjuejse6uo:Jeo m'v - t~n ~' ~z OG6'z SJOjeI!Po4:JUOJS 608'g - oWz 8'Ol OS~'V seUIWejS14!jUIf ~89'vt - SgO'tz SO~ L98'8z SlN381f ACJ01 IftJldS3CJ tz9'~ - vLS 6' ~S 666 sjue6e SNJ snoeuelle:Js!V'J 9L6'8 - 80n ~n m'L eupdezueQol:JAJ 899'9S - Z9t'U Gtz gOg'yZ IOPoJdospeJ 0~9'~9 - 9ZS'9Z 9'9~ 8 ~6'8S sjuexeleJ el:JsnV'J punoq punoq (3S~) Jom Jaddn JaMol pJepuets vt'zSt!S!^ ~ s6nJp papalas pue sa!Jo6ate:l 6nJp papalas a^!tela~ patew!tS3 le~atu! a:luapljuo:l %S6 900Z :Sle:mna:>eWJe4d 10 asn le:>!paWUON (penuquO:l) 6 alqel ~ .. Table 10 Nonmedical use of pharmaceuticals, by patient and visit characteristics: 2006 Patient characteristics Estimated Visit characteristics Estimated visits 1,2 visits 1,2 ED visits, nonmedical use 741,425 Gender Number of drugs involved Male 353,066 Single drug 341 ,796 Female 388,084 Multiple drugs 399,629 Unknown ... Age Disposition 0-5 years 6,360 Treated and released 430,260 6-11 years 4,366 Discharged home 392,512 12-17 years 65,268 Released to police/jail 17,646 18-20 years 51,972 Referred to detox/treatment 20,102 21-24 years 71,351 Admitted to this hospital 223,622 25-29 years 73,753 ICU/critical care 64,777 30-34 years 66,650 Surgery 876 35-44 years 157,450 Chemical dependency/detox ... 45-54 years 131,797 Psychiatric unit 49,413 55-64 years 50,933 Other inpatient unit 104,633 65 years and older 61,346 Other disposition 87,543 Unknown 181 Transferred 49,514 Race/ethnicity Left against medical advice 16,097 White 508,708 Died 1,574 Black 77,553 Other '" Hispanic 59,847 Not documented 5,459 Race/ethnicity not tabulated above 8,433 (NTA) Unknown 86,884 1 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. 2 Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). Note that ED records frequently do not distinguish methadone used for treatment of opiate addiction from the methadone in pill form that is prescribed for pain. In fact, methadone may be one of the most ambiguous drugs to categorize in DAWN. When a patient on opioid replacement therapy presents to an ED, methadone may be routinely documented in the medical record, but without sufficient information to distinguish whether the methadone was related to the ED visit. DAWN, 2006: NATIONAL ED ESTIMATES 37 . S31VV>lIlS3 03 lVNOl1VN :90Ol 'NMVO 9f: 'S1U868 AJ018Jids8J S8 "6'8 '8J84M8S18 P8il!SS8P 8J8 8U!W8JPA4U84diP 6UiU!81UOJ SI8JIln8J8WJ84d lU8iP8J6ui-illnw AU8V1j 'SUOn8InWJOllU8iP8J6U!-816U!S AIUO S8pnpU! si41 9~ 'Ja6UnOA pue ~ ~ pa6e SIUa!led JOJ ISaMol aJaM pue 1717 01 8 ~ pa6e SIUa!led JOJ ISa46!4 aJaM SaleJ I!S!^ 'a6e JO SWJal ul '(9 am6!.::!) (uO!lelndod 000'00 ~ Jad SI!S!^ LEG) salew pue (uO!lelndod 000'00 ~ Jad SI!S!^ E9G) salewaJ uaaMlaq JaWP IOU PIP Sle:l!lna:leWJe4d JO asn le:l!pawuou JOJ SI!S!^ 'luno:l:le 01U! JOJJa JO u!6Jew a41 pue az!s UO!lelndod 6u!~e1 'alep!Ua4dlA41aw pa^IO^U! SI!S!^ 03 asn-Ie:l!pawuou (pOp'E 01086 :18) G6 ~ 'G W41 salew!lSa NM\fO 'AlluanbaJJ ssal 4:lnw SJn:l:lO 'UO!lUane 4:lnW paJnlde:l se41e411uelnw!IS SN8 e 'alep!Ua4dIA41aV\l '(L8E'G9 01 OSO'LE :18) SI!S!^ 03 EU'pp U! 'au!de!lanb se 4:lns 'S:l!104:lAsd!lU\f III pue '(8EE'E6 019W'99 :18) SI!S!^ 03 G89'6L U! slueSsaJdap!lu\f II :saleW!ISa NM\fO 'S:l!104:lAsd!IUe pue slUeSsaJdap!lue apnpu! ISaJalu! JO slua6e :l!lnadeJa4104:lAsd Ja410 'Sle:l!lna:lewJe4d JO asn le:l!paWuou 41!M pale!:losse SI!S!^ 03 a41 JO.::! '(6E6'H 01 EP9'6 :18) SI!S!^ 03 ~6tG~ U! 9~au!WeJpA4Ua4d!0 II pue '(E~6'p~ 01 890'L :18) SI!S!^ 03 ~66'0~ U! 'paweuun Alpewpd aJe 4:l!4M 'SaleJnl!qJes II '(G88'G(: 01 EE9' ~ ~ :18) SI!S!^ 03 L9tH U! wap!dlOZ III :SI!S!^ 03 asn-Ie:l!pawuou JO sJaqwnu Jel!W!S U! paJeadde s6nJp 6u!MOIIOJ a41 'S:l!IOudA4 pue 'Sa^!lepaS 'S:l!lAIO!Xue Ja410 a41 6uow\f 'SI!S!^ 03 (p9L'tG 01 80~'9~ :18) 9E6'6~ U! wedaze!p pue SI!S!^ 03 (~9E'8G 016LO'6~ :18) OGL'EG U! wedazeJOI papnpu! sJaqwnu le!IUelsqns U! 1I!IS lnq AllUanbaJJ ssal 6upJn:l:l0 sau!daze!pozuaS 'SI!S!^ 03 (OG ~ 'E8 019L9'EE :18) 8pE'89 :sJaqwnu Jel!W!S U! paJeadde paweu lua!paJ6u! :l!Jpads e ln041!M sau!daze!pozuaS 'SIISI^ 03 (pE9' ~ 17 01 089'9G :18) L99'EE U! wedazeuop pue SI!S!^ 03 (~99'6L 01 ~ ~6'09 :18) 9Et99 U! WelOZeJdle aJaM sau!daze!pozuaq paweu AllUanbaJJ ISOW a41 'NM\fO 016u!pJo:l:l\f '900G U! sau!daze!pozuaq pa^IO^U! Sle:l!lna:leWJe4d JO asn le:l!paWuou 41lM pale!:losse SI!S!^ 03 (~gp'EG(: 0168L'L9~ :18) 9G9'96~ le41 SaleW!lsa NM\fO 'slua6e :l!lnadeJa4104:lAsd JO sadAl Ja410 a41 JO Aue 6u!^10^u! as041 Jaqwnulno Apeap sau!daze!pozuaq 6u!^10^u! SI!S!^ 03 'sau!daze!pozuaq pue saleJnl!qJeq sapnpu! Sle:l!lna:leWJe4d JO AJ06ale:l S!41 'sle:l!lna:leWJe4d JO asn le:l!paWuou 41!M paleposse SI!S!^ JO (%W PJ!41 e lnoqe JO (L9P'09G 01 p6tLOG :18) 9L8'EEG U! 6upJn:l:l0 'luanbaJJ ISOW a41 aJaM S:l!IOudA4 pue 'sa^!lepas '(slua6e Ala!xue-!lue) S:l!lAIO!XUe a41 'slua6e :l!lnadeJa4104:lAsd a41 6uow\f '900G U! SI!S!^ 03 asn-le:l!paWuou JO '%E JO '(899'9E 01 G9n~ D) 909'pG U! pa^lo^u! seM 4:l!4M 'IOPoJdospe:l seM SI!S!^ asn-le:l!paWuou U! lUexelaJ apsnw luanbaJJ ISOW a41 'spnpoJd Ua4dou!wela:le p!o!douou 6u!^10^U! SI!S!^ asn-Ie:l!pawuou (9p~'G9 01 G8P'9E :18) p~np SaleW!ISa NM\fO '(%17 'SOI\fSN) slua6e AJOlewweIJU!-IIUe lep!OJalSUOU pue '(%17) sIUeSln^UO:l!lue '(%9) sluexelaJ apsnw '(SI!S!^ asn-Ie:l!pawuou JO %9) Ua4dou!Wela:le 6u!U!eluO:l s:l!sa6IeUe p!o!douou a41 Aq A:luanbaJJ U! paMolloJ aJaM sp!o!do a41 In terms of race and ethnicity, 69% of visits related to nonmedical use of pharmaceuticals involved patients who were white (Table 10). Evaluating the relative frequencies of the race/ethnicity groups is impeded by missing data; in 12% of visits, race/ethnicity was unknown. Patients were treated and released in about half (58%) of ED visits associated with nonmedical use of pharmaceuticals, with most discharged home (91 %) and only 5% referred to detox or substance abuse treatment. In one third (30%) of all nonmedical-use visits, patients were admitted to inpatient hospital units (Table 10). Of those admitted to the hospital, about one third (29%) were sent to a critical care unit, about 22% to a psychiatric unit, and about half (47%) to other inpatient units. About 7% of ED visits for nonmedical use of pharmaceuticals resulted in transfers to another health care facility. Figure 5 Nonmedical use of pharmaceuticals, ED visit rates by age and gender: 2006 500 500 41 0 4~~ c 400 c 400 0 0 '';:; '';:; re re :; :; "'- "'- 0 0 "'- 300 "'- 300 0 0 253 0 0 0 0 237 r-'" 6 6 0 0 I ~ 200 ~ 200 :;:; :;:; I "'- "'- 2 2 I' re re ex:: ex:: 100 100 0 0 I lrl ...... 0 """ O'l """ """ """ """ + Male Female 6 N ":' N CV) "'r lrl co lrl <l, N 00 J, 6 lrl J, J, co N N CV) CV) """ lrl SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 39 40 DAWN, 2006: NATIONAL ED ESTIMATES o o COMPARISONS OF ED VISITS: 2004, 2005, AND 2006 his chapter presents the comparison of the estimates of ED visits for 2006 to prior years. Differences between years are presented in terms of the percent increase or decrease in visits in 2006 compared to the estimates for 2004 or 2005. Only statistically significant changes are discussed and are shown as changes in the tables. However, with only three years' estimates to compare, caution is urged in interpreting these significant differences as trends. Drug misuse and abuse in ED visits (Table 11) In 2006, hospitals in the United States delivered a total of 113 million ED visits, an increase of 3.9% over 2004. The population of the United States increased 2.9%, from 294 million to 302 million, over the same period. According to DAWN, the number of ED visits attributable to drug misuse and abuse was stable from 2004 to 2006 (Table 11 ).16 That is, the apparent difference is within the margin of error. Across the different types of drug involvement, changes were detected for visits involving: III pharmaceuticals alone (i.e., with no other type of drug), which increased 44% from 2004 to 2006; III pharmaceuticals used in combination with illicit drug(s), which increased 36% from 2004 to 2006; and I'i! pharmaceuticals used in combination with alcohol, which increased 22% from 2005 to 2006. Regarding the significant increases detected, it is worthwhile to consider that the number of pharmaceuticals dispensed for legitimate therapeutic uses may be increasing over time, and DAWN estimates are not adjusted to take this into account. Nor do DAWN estimates take into account the increases in the population or in ED use between 2004 and 2006. 16 In this publication, drugs are classified using the Drug Reference Vocabulary that was current as of May 2007. DAWN, 2006: NATIONAL ED ESTIMATES 41 S31lfv.l11S3 03 llfNOl1lfN :900<: 'NMlfO Zv '(al8pdn BOOlIEO) 900l '~JOMlaN 6U!UJ8M asnqlf 6nJO '\fSHVIJIfS 'Sa!pnlS pa!lddlf jO aO!jjO :3~tlnOS 'uMoLls spopad aLll JOj sal8wIlsa uaaMlaq SaS8aJOap JO SaS8aJOU! (90'0> d) lU80!j!u6!s AII80!IS!181S salouap uwnloO sILl1 'sal81 S pal! U n aLll U! s03 JnOLl-vl Lll!M SI81!dsOLl A81S-jJOLlS '18Japa,j-uou jO aldw8s a^!181uasaJdaJ 8 UO pas8q SI!S!^ 03 jO SaI8W!ISa aJ8 asaLl1 'UIoownllnuIMMM/rdlllll8 laUJalul aLll uo punOj aq U80 PU8 If x!puaddlf U! pap!^oJd S! UOJ!X;n alii jO asn 6u!uJa^061uawaaJ6v 6u!sUaOll wnlln~ aLl1 '(LOOl) SIUaWaJlnbaJ anblun S,NMVO laaw 01 paw pow S8M UO!180!j!SS8P a1l1 'oul 'sao!^,JaS UO!18WJOjUI wnlln~ 'LOOl @ 'UOJ!Xa7 wnlln~ aLll WOJj pa^pap S! NMVO U! pasn s6nJp jO UOI180!j!SS8P a1l1 ~ E99'69 009'v9 ~L9'9v S180!lna08WJ8Lld PU8 IOLlO:>I8 Lll!M s5nJp 1101111 %ll Ev L' w 9LtOv ~ 9~L'60 sl8ollna08WJ8Lld Lll!M 10LlooIl/ %9E 9E9'lv~ 9vtW nO'90~ sl801lna08wJ8ljd ljl!M s6nJp 1!0!1I1 ~l9'6~l ElB' ~ll BE9'BEE IOljOol8 ljl!M s6nJp 1!0!1I1 suol18UlqWOJ %vv 9Lt9Bv 60E'vvv LB6'9EE AIUO sl80!lna08wJ8ljd vOL'9l ~ 669'0 ~ ~ BB6'09 ~ (~l > a68) AluO 10ljooll/ v99'9E9 B99'n9 9E ~ 'l09 AIUO s6nJp llO!111 Lllll'lvn ~ ~ E'9 ~9' ~ v90'6~9'~ 8snqBj8SnS!W 5nJp 10 s8dA11I'V gOal 'gOal gOal 'vaal gOal gaOL vaal ~IU8W8^10^U! 5nJO 885uBljO lU80J8d <:SI!S!^ P81BW!IS3 900~ pue 'SOO~ 'VOO~ :JuewaAIOAU! 5nJp JO adAJ Aq "s'n a4J U! SJ!S!A 03 U! asnqe pue asns!w 5nJO ~ ~ alqel Illicit drugs in ED visits (Table 12) No changes from 2004 to 2006, nor from 2005 to 2006, were detected for ED visits involving major illicit drugs: cocaine, marijuana, heroin, and stimulants (Table 12). Table 12 Illicit drugs in ED visits: 2004, 2005, and 2006 Drug category and selected drugs 1 Estimated visits2 Percent change3 2004 2005 2006 2004,2006 2005,2006 Total drug misuse/abuse ED visits 1,619,054 1,616,311 1,742,887 ED visits, illicit drugs 991,363 921,127 958,164 Cocaine 475,425 483,865 548,608 Heroin 214,432 187,493 189,780 Marijuana 281,619 279,664 290,563 Stimulants 162,435 137,650 107,575 Amphetamines 34,085 34,928 32,240 Methamphetamine 132,576 109,655 79,924 MDMA (Ecstasy) 10,220 11,287 16,749 64% 48% GHB 1,789 1,036 1,084 Flunitrazepam (Rohypnol) ... ... ". Ketamine ... 303 270 LSD 2,146 2,001 4,002 100% PCP 31,342 14,825 21,960 Miscellaneous hallucinogens 3,150 3,194 3,898 Inhalants 9,523 5,156 5,643 -41% Combinations not tabulated above 3,201 2,055 (NTA) ... The classification of drugs used in DAWN is derived from the Multum Lexicon, @ 2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at httpJ/www.l1Iultum.com. 2 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. This column denotes statistically significant (p < 0.05) increases or decreases between estimates for the periods shown. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 43 " S31V~IlS3 03 lVNOl1VN :90Ol 'NMVO vv '(ajepdn BOOl/EO) 900l '~JoMjaN 5u!UJeM asnq\f 5nJO '\fSHl^J\fS 'sa!pnjS pa!lddv)o aO!JJO :3::>~nOS 'uMoLls spopad aLlj JO) sajew!lsa uaaMjaq saseaJoap JO saseaJou! (90'0 > d) jueo!)!u5!s AlleO!jS!jejs sajouap uwnloO S!L11 S 'sajejS paj!Un aLlj U! s03 JnoLl-vl L1j!M Slej!dsOLl AejS-jJoLlS 'reJapa::l-uou )0 ardwes a^!jejuasaJdaJ e uo paseq Sj!S!^ 03 )0 sajew!jsa aJe asaLl1 ~ 'woownlII1WMMM!/d1l4je jauJajUI aLlj uo puno) aq ueo pue \f x!puadd\f U! pap!^oJd S! uO:J!xe7 aLlj)O asn 5uluJa^05juawaaJ5\f 5u!suao!l Wl1jrl1l^J a41 '(LOOl) sjuawaJ!nbaJ anb!un S,NM\fO jaaW,Oj pal)!pOW seM UO!jeo!)!ssep a41 'our 'sao!AJas uO!jewJO)Ur wnjlnl^J 'LOOl @ 'uo:J!Xe7 wnjrnl^J aLlj WOJ) pa^pap S! NM\fO U! pasn s5nJp)0 uO!jeo!)!ssep aLl1 U6'tL l8E'L9 L8nO~ auole 10LlOOI\f lOnE v8L'a 9l6'~€ uOljeu!qwoo U! 10LlOOI\f 9L9'90 ~ 99 ~ '96 H€'m 10Lloole 'Sj!S!^ m Ol-8 ~ palle Sjua!led lvt'l9 6€L'lv v€0'9v auole 10LlOOI\f 8 ~ V'Vl OU6 ~ 999' ~l uOljeu!qwoo U! 10Llool\f 09L'9L 69V'l9 689' L9 10Llo::lle 'Sj!S!^ m L ~ -l ~ palle sjua!led 900l'900l I 900l'vOOl salluBLlO luaoJad 900l I 900l I vaal ~ sllnJp papalas pUB AJollalBO llnJO ~Sl!S!^ palBW!ls3 900l pue 'gOal 'vaal : ~l aBe Japun Slua!led U! Sl!S!^ 03 palelaJ-BnJp U! I0400lV v~ alqel '(ajepdn 800l/EO) 900l '~JOMjaN 5u!UJeM asnq\f 5nJO '\fSHl^J\fS 'sa!pnjS pa!ldd\f )0 ao!))o :3::>~nos 'UM04S spopad aLlj JO) sajew!lsa uaaMjaq saseaJoap JO saseaJou! (90'0 > d) jueo!J!u5!s Arle::l!jS!jejs sajouap UWnlO:J S!41 S 'sajejS paj!Un aLlj U! sm mOLl-vl L1j!M Slej!dsOLl AejS-jJ04S 'leJapa::l-uoU )0 ardwes a^!jejuasaJdaJ e uo paseq Sj!S!^ 03 )0 sajewljsa aJe asaLl1 'WOO'WI111I1w'MMM//dnLlje jauJajul aLlj uo puno) aq ue::l pue \f x!puaddv U! pap!^oJd S! UO:J!xa7 aLlj)O asn 6u!uJa^06juawaaJ5v 5U1suao!l wnjll1l^J aLl1 '(LOOl) SjuawaJ!l1baJ anb!un s,NMVO jaaw OJ pa!)lpow seM uO!le::l!)lssep aLl1 ':Jul 'sa::l!AJas uO!jeWJo)ul wnjlnl^J 'LOOl @ 'UO:J!xe7 wnjlnl^J aLlj WOJ) pa^pap sl NM\fO U! pasn s5nJp)0 uO!jeO!)ISSep aLl1 ~ vOL'9l ~ 669'0 ~ ~ 886'09 ~ auolB 10LlO::lI\f LW09v 669'9 ~ v 9l6'tl9 UOljBUlqWO::l U! 10Llo::lI\l ~ 19' LL9 86~'a9 v~6'vL9 10LlO::lIB 'SI!S!^ 03 LBB'lv L' ~ m'9~9'~ v90'6W~ Sl!S!^ 03 asnqB/asns!w llnJp IBl01 900l'900l 900l'vOOl 900l goo<: vaal ~ sllnJp papalas pUB AJollalBO llnJO salluB4::1 luaOJad ~Sl!S!^ palBWns3 900l pue 'gOal 'vaal :Sl!S!^ 03 palelaJ-BnJp U! I0400lV S~ elqel 'SIUa!l8d a58JapUn U! auol8 1040018 PU8 's5nJp Ja4l0 4l!M UO!l8U!qwoo U! 1040018 '1I8JaM 1040018 :Sl!S!^ 03 pal8jaJ-1040018 a4l118 JOJ lUalS!SuOO aJaM s5u!pu!J asa41 '(v~-t~ salq81) 900Z Ol900Z popad a4l JOJ JOU '900Z Ol VOOZ WOJJ popad a4l 5upnp paJJnooo Sl!S!^ 03 pal8IaJ-10400\8 U! sa5u840 lU80!J!u5!s ON (v~-c ~ salQel) Sl!S!^ 03 U! I04031V Nonmedical use of pharmaceuticals (Table 15) ED visits related to nonmedical use of pharmaceuticals increased 38% in the period from 2004 to 2006 (T able 15). Among the drugs most frequently implicated in nonmedical use, the following changes from 2004 to 2006 are notable: III Psychotherapeutic and eNS agents increased 31 % and 32%, respectively. III Anxiolytics, sedatives, and hypnotics increased 32% overall, with benzodiazepines increasing 36%. III Opiate/opioid analgesics increased 43%, with hydrocodone/combinations increasing 44%, oxycodone/combinations increasing 56%, and unspecified opiates increasing 60%. For the period 2005 to 2006, no change was detected in the overall number of ED visits related to nonmedical use of pharmaceuticals nor were changes noted for the substances most frequently implicated in nonmedical-use visits. Table 15 Nonmedical use of pharmaceuticals ED visits: 2004, 2005, and 2006 Drug category and selected drugs 1 Estimated visits2,3 Percent change4 2004 2005 2006 2004,2006 2005,2006 ED visits, nonmedical use 536,247 669,214 741,425 38% PSYCHOTHERAPEUTIC AGENTS 247,324 308,655 323,999 31% Antidepressants 66,917 67,051 79,682 MAO inhibitors ... ... ... SSRI antidepressants 32,285 30,374 35,370 Tricyclic antidepressants 12,412 14,515 16,564 Miscellaneous antidepressants 9,414 7,452 7,561 Antipsychotics 35,198 44,393 44,733 Anxiolytics, sedatives, and hypnotics 177,394 227,486 233,875 32% Barbiturates 11,721 14,693 10,991 Benzodiazepines 143,546 189,704 195,625 36% Alprazolam 46,526 57,419 65,236 40% Clonazepam 28,178 30,648 33,557 Diazepam 15,619 18,433 19,936 Lorazepam 17,674 23,210 23,720 Benzodiazepines NOS 36,039 61 ,486 58,347 Misc. anxiolytics, sedatives, and 31,554 35,561 40,626 29% hypnotics Diphenhydramine 10,452 10,294 12,291 Hydroxyzine 2,363 2,179 2,678 Zolpidem 12,792 14,730 17,257 Anxiolytics, sedatives, and 2,657 4,421 3,629 hypnotics NOS DAWN, 2006: NATIONAL ED ESTIMATES 45 S31lfV'jIlS3 03 lIfNOlllfN :900<: 'NMlfO 917 S6S f:'19 LL6 (,</IN) a^oqB pajBlnqBj JOU SUOljBU!qWO:J :J!saBIBU,</ ", ", 606 10pBWBJj-ua~dou!WBja:J,</ f96''1 af'1 sv6'f: 10pBWBJl SVO'9 Sf6''1 6VB'v SUO!jBU !qwo:J/lopBWBJ 1 Vff:'VV s'1'1tv L9f'6f: SUO!jBU!qwo:J/ua~dou!WBja:J,</ Hf:'v'1 fSS'f'1 L'1S'vv SUO!jBU!qWO:J ISO!saBIBUB snoauBllaos!~ 66t'0 f f:2:f'2:f OS'1'6 SUO!jB U! q wo:J ISajB IAO!I B S f'19'9 06f''1 '1fL'V UaXOJdBN fV'1'02: S9tu W'U uaJoJdnql 2:99'a Lf:S'S2: 2:9f:'a SjUaBB AJOjBWWBIJU!-!jUB IBp!OJajsUON 02:t9 SV9'L VV L'9 SUO!jBU!qwoo/aua~dAXodoJd %9'1 SSS'V9 f:v6'2:'1 fOL' fV SUOIjBU!qwoo/auopooAXO %9v 9 f f02: 2:9L''1f 996tf SUO!jBU!qwoo/au!~dJo~ Of:f''1V VS9'2:V 90S'9f: aUOpB~ja~ OVV'f f:Sf: 2:SL SUOIjBU!qwoo/aU!P!Jada~ OSL'9 VfL'V '1Sn SUO!jBU !qwoo/auo~dJowoJ PAH %vv O'1'1'L'1 2:6f'Lv vVB'6f: SUO!IB U!qwoo/auopo:JOJpAH 2:fO'9f ffnf f:2:S'6 SUOIjBU!qwooIIAuBlua::l S2:6'9 OSf'9 W'L SUO!jBU!qwoo/au!apoJ OVV'v '" '" suo !jB U! q W 00 lau! ~dJOU aJ d n 8 %02: %6f: ost f02: 9Lf:'S9 f VV9'VVf so!saBIBUB O!IOOJBN %09 SL6'O'1 OL9'2:'1 9VS'ff: pa!Jpadsun 'SP!O!dO/SaIB!do %f:v 699'Lv2: v6'1'n2: 9UW SP!O!dO/SaIB!do '" '19L '1f:6'f SJOj!qlljU! 2:-XOJ f6f'f SfO'f S9S sluaBB aU!BJB!w!lu,</ %vf: 6L'1t2:f: f'1tv62: SL'1'fV2: so!saBIBu,</ %2:f: SH'Uf: 006'9f:f: 96G'GS2: SlN38'</ ~31SASSnO^~3Nl'</~lN3J m'2: 6f'1'2: 9VV'2: aIBP!Ua~dIA~ja~ '" '" '" aUlwBla~dwBOJIXao LOV'v L9'1'v 9f:L'2: aU!aUBJ %Sff ao''1 699'2: tDf:'2: aU!WBla~dwBOJIXap-aU!WBja~d w'</ %2:v 2:6Stf '196'Of f0B'6 sIUBlnW!IS SNJ 900l''1OOl 900l'vOOl 900l '1OOl POOl ~ sBnJp pajoalas pUB AJoBajB:J BnJO vaBUB4:J juaOJad €'<:Sj!S!^ pajBw!ls3 gOal pUB 'gOal 'vaal :Sl!S!^ 03 SIB:mna:>BWJB4d }O asn IB:>lpawuoN (panulfuo8) g~ elqel Table 15 (continued) Nonmedical use of pharmaceuticals ED visits: 2004, 2005, and 2006 Drug category and selected drugs 1 Estimated visits2,3 Percent change4 2004 2005 2006 2004,2006 2005,2006 Anorexiants ... 1,757 1,168 Anticonvulsants 28,652 27,641 31,169 Antiemetic/antivertigo agents 1,678 1,771 1,360 Anti-Parkinson agents 2,472 1,692 3,816 General anesthetics ... ... ... Muscle relaxants 25,934 33,695 38,918 50% Carisoprodol 14,736 20,082 24,505 Cyclobenzaprine 6,183 7,629 7,142 Miscellaneous CNS agents 869 900 999 RESPIRATORY AGENTS 22,286 28,017 28,867 Antihistamines 5,761 4,429 4,130 Bronchodilators 2,294 3,043 2,920 Decongestants 1,864 1,310 1,511 Expectorants 832 1,960 2,125 155% Upper respiratory combinations 10,314 15,837 15,115 Respiratory agents NT A 2,903 3,692 4,296 CARDIOVASCULAR AGENTS 27,396 37,095 36,343 Antiadrenergic agents, centrally acting 3,616 5,125 4,810 Beta-adrenergic blocking agents 7,094 9,824 11,729 Calcium channel blocking agents 3,115 5,434 5,227 Diuretics 3,625 5,332 5,102 Cardiovascular agents NT A 14,930 18,881 17,338 The classification of drugs used in DAWN is derived from the Multum Lexicon, @ 2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at http://www.multum.com. 2 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. 4 This column denotes statistically significant (p < 0.05) increases or decreases between estimates for the periods shown. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 47 S31VV'JIlS3 03 lVNOIlVN :900(; 'NMVO st> SPECIAL TYPES OF DRUG-RELATED ED VISITS his chapter profiles two special types of drug-related ED visits captured by DAWN: drug-related suicide attempts and seeking detox cases. These are analyzed by DAWN as separate and distinct classes of drug misuse or abuse. Suicide attempts (Tables 16-17, Figure 6) DAWN estimates 182,805 (CI: 154,185 to 211,424) ED visits for drug-related suicide attempts in 2006 (Table 16). Although DAWN includes only suicide attempts that involve drugs, these attempts are not limited to drug overdoses. If there is drug involvement in a suicide attempt by other means (e.g., by gun), the case is included as drug related. However, suicide attempts not involving drugs at all (e.g., by gun alone) are excluded. Also excluded are suicide-related behaviors documented as something other than actual attempts (e.g., suicidal ideation, suicidal gesture, or suicidal thoughts). Nearly two thirds (65%) of ED visits for drug-related suicide attempts involved multiple drugs (Table 17). Alcohol, either in combination with other drugs or alcohol alone in patients under age 21, was the most frequently implicated drug and was involved in one third (30%) of the ED visits for drug-related suicide attempts. Since DAWN excludes visits for adults when alcohol is the only drug, the role of alcohol in suicide attempts is probably larger. Illicit drugs were involved in just under one quarter (23%) of the ED visits for drug-related suicide attempts. The most frequently reported illicit drugs were cocaine (15% of visits) and marijuana (8% of visits), but the margins of error for the illicit drugs are quite large and the numbers are relatively small when compared with the pharmaceuticals. Pharmaceuticals were involved in the majority (92%) of ED visits for drug-related suicide attempts, and it is not possible, based on ED medical record documentation, to measure the extent to which these pharmaceuticals may have been prescribed to the patient for a preexisting condition. More than half (58%) of ED visits for drug-related suicide attempts involved psychotherapeutic agents, and 45% involved central nervous system (CNS) agents. The most commonly used psychotherapeutic agents were benzodiazepines (48% of suicide-attempt visits involving psychotherapeutics) and antidepressants (35%). The CNS agents were primarily analgesics (pain relievers) and included both prescription and over-the-counter (OTC) formulations. DAWN estimates that the most commonly used pain relievers were opiates/opioids and acetaminophen/combinations, which were each present in approximately a third (33% and 31%, respectively) of suicide-attempt visits involving CNS agents, followed by nonsteroidal anti- inflammatory agents (NSAIDs, such as ibuprofen and naproxen, 19%) and salicylates/combinations (aspirins, 7%). About half (55%) of the suicide attempts were admitted for inpatient hospital care. A fifth (21%) were admitted to an ICU/critical care unit; others were admitted to psychiatric units (18%) or other inpatient units (16%). Another 25% were transferred to another health care facility; only 14% were discharged home. Very few died in the ED. However, DAWN does not record deaths for patients who died before arriving at the ED or patients who died after admission to inpatient units of the hospital. DAWN, 2006: NATIONAL ED ESTIMATES 49 S31VVlllS3 03 lVNOIlVN :900Z 'NMVa 09 OG9'H 9U'Of V'Gf W'Vf wedazeUOIJ vL6'6f f6nf G"Vf EE9'9f WelOZeJdrif GES'L9 OEO'tv 9'L fEV'09 sau!daze!pozuaS 969't L9E S'fV fto'G sajeJnj!qJes EU'LL GE9'S9 f'L LH'S9 SO!joud^4 pue 'sa^!jepas 'SOlj^IO!XU\;I 9 f V'SG 999'9f Hf f6V'a SO!j040^sd!ju\;I E96'9 099' f SSG 90S't sjuessaJdap!lue snoauellaos!V>J 99tL LOf'G f'SG fS9'V sjuessaJdap!jue 0!P^OP1 6S9'OG L9t'H 6'Of tL6'9f sjuessaJdap!jue ItJ88 SJOj!q!4U! O\;lV>J vsL'9v OL9'a L'Gf LL9'9E sjuessaJdap!ju\;l fLS'fGf 9SE'06 9'L SU '90 f 81N38\;1 Jl1n3d\;ltJ3HlOHJA8d saouejsqns Ja4jO (\;I1N) a^oqe pajelnqejjou suo!leu!qwoJ sjuele4uI sua50upnlle4 snoauellaos!V>J S' fL dJd 081 au!weja)i (loud^40tJ) wedazeJj!Unl.::J SH8 LLn fOf 6'9v 6En (^SejS03) \;IV>JOV>J an an 9'LG LLS'G aU!Weja4dwe4jaV>J E9t't VOf'f S'9G SGtG saU!Weja4dw\;l Of9'9 SWE S'Sf 6GS'v sjuelnwlj8 W'tG fLE'L v'9G Ut9f euenflJeV>J a9'9 E06'f E'SG 99G'V u!oJaH 9fE'Ov 90L'G f 9'9G Of9'9G au!eooJ GSn9 vf6'a t'tG SVf'GV Sjp!!1! 104001e-uoN E06 E9 V'Vv ESv auole 104001\;1 LSO'09 LS9'Sv v'9 LEn9 uO!jeu!qwoo U! 104001\;1 Lv9'09 E66'Sv V'9 OGS'v9 104001\;1 asnqe to saouejsqns JO[eV>J pZv'm - 98f'P9f 0'8 908'ZS f SjdwallB ap!o!ns 'Sj!S!^ 03 pajBlaJ-5nJp IBj01 punoq - punoq (38tJ) JOJJa Jaddn JaMOl pJBpUBjS V'E'ZSj!S!^ f s6nJp pajoalas pUB ^J06ajeo 6nJO a^!jBlatJ pajBw!ls3 IB^JajU! aouap!!uoJ %96 900l :Sldwane ap!o!ns 9 ~ alqel Table 16 (continued) Suicide attempts: 2006 Relative 95% Confidence interval Estimated Drug category and selected drugs 1 visits2,3,4 standard Lower Upper error (RSE) bound - bound Diazepam 5,910 24.4 3,086 - 8,733 Lorazepam 6,682 13.6 4,904 - 8,460 Benzodiazepines NOS 7,080 35.9 2,092 - 12,069 Misc. anxiolytics, sedatives, and hypnotics 21,527 9.7 17,443 - 25,611 Diphenhydramine 7,756 14.6 5,543 - 9,970 Hydroxyzine 1,957 23.6 1,053 - 2,860 Zolpidem 6,674 13.6 4,890 - 8,458 Anxiolytics, sedatives, and hypnotics NOS 1,406 25.7 698 - 2,115 CNS stimulants 1,949 33.1 683 - 3,214 Amphetamine-dextroamphetamine 559 47.5 38 - 1,079 Caffeine ... ... ... - ... Dextroamphetamine ... ... ... - ... Methylphenidate 633 39.6 141 - 1,124 CENTRAL NERVOUS SYSTEM AGENTS 82,442 7.3 70,683 - 94,201 Analgesics 67,623 7.4 57,880 - 77,366 Antimigraine agents ... ... ... - ... Cox-2 inhibitors ... ... ... - ... Opiates/opioids 27,185 9.9 21,928 - 32,442 Opiates/opioids, unspecified 3,129 23.5 1,686 - 4,573 Narcotic analgesics 24,470 10.0 19,695 - 29,244 Buprenorphine/combinations ... ... ... - ... Codeine/combinations 2,349 22.7 1,306 - 3,392 F enta nyl/ co mbi nati ons ... ... ... - ... H yd rocodon e/ co m bi nations 8,998 11.4 6,981 - 11,016 H yd romorphone/ co m bi nations 262 49.5 8 - 516 Meperidine/combinations ... ... ... - ... Methadone 1,772 29.3 755 - 2,788 Morphine/combinations ... 50.5 ... - ... Oxycodone/combinations 7,842 18.9 4,934 - 10,750 P ropoxyph e n e/ co m bin ations 2,811 26.9 1,331 - 4,292 Nonsteroidal anti-inflammatory agents 15,956 15.0 11,280 - 20,632 Ibuprofen 12,064 15.0 8,523 - 15,605 N aproxen 3,726 20.9 2,201 - 5,252 S a I icyl ates/com bi n ati ons 5,400 10.4 4,294 - 6,506 DAWN, 2006: NATIONAL ED ESTIMATES 51 S31Vv.l11S3 03 lVNOl1VN :900Z 'NMVO Z~ (ajepdn BOOZ/tO) 900Z '~JOMjaN 5u!UJeM asnqlf 5nJO 'lfSHlf'JlfS 'SalpnjS pa!lddlf )0 a~!!!o :3::nmOS 'uM04s spopad a4j JO) sajew!lsa uaaMjaq saseaJ:Jap JO saseaJ~u! (SO'O > d) jue:J!)!u5IS Alle:JljSljejS sajouap uwnlo:J S!41 'passaJddns uaaq se4 Ot ue4j ssal ajew!jsa ue JO %OS ue4j JajeaJ5 3SCl ue 4j!M ajewljSa ue je4j aje:JIPuI (',,) SjOp aaJ41 t 'sajej S pajl u n a4j uI s03 Jn04-vZ 4j!M Slejlds04 AejS-jJ04S 'leJapa.::J-uou)O aldwes aAljejUasaJdaJ e uo paseq Sj!S!A 03)0 sejeWljSe eJe ese41 'wo:J'wnllnwMMM//dllLlje jeuJejul e4j uo puno) eq ue~ pue If xIPueddlf U! pep!AoJd sl uO:J!Xi17 e4j)0 esn 5UIUJeA05juaweeJ5v 5uisue:J!l wnjlnlf'J eLl1 '(LOOZ) sjueweJlnbeJ enb!un s,NMlfO jeew OJ pe!)!pow seM uO!je:J!)lssep e41 ':Jul 'Se~IAJes UOljeWJo)ul Wnjlnlf'J 'LOOZ Q) 'uOJ/xa7 Wnjlnlf'J eLlj WOJ) peApap S! NMlfO U! pesn s5nJp)0 UO!je~I)ISSep e41 S6L'v - 66n ~'€Z S6tt V 1N sjue5e Jeln:JseAOIPJeJ ..' - '" 0' ~g ,.. s:J!jeJn!o V ~g' ~ - ggv Z'SZ ova' ~ sjue5e 5u!~:J0Iq leuuelj:J wnpleJ g6L'Z - zot~ 8'OZ 666'~ sjue5e 5u!~:J0Iq :J!5JeueJpe-ejes Zv6'Z - L~6 S'g~ 086'~ 5u!pe AlleJjUe:J 'sjue5e :J!5JeueJpe!julf Zvg'O ~ - 6S8'g gg~ g96'L SlN381f CllflnJSIf ^OIOClVJ vBO'~ - g8~ S'Z8 099 V IN sjue5e AJojeJ!dsaCl v6tg - OL9'~ S'g~ ZS6'8 suoijeu!qwo:J AJojeJ!dseJ Jaddn gLL'~ - ~98 S'88 S90' ~ sjueJOpedx3 g~tz - 6Lv 6'Z8 Lvn sjuejse5uo:JeO '" - .., .., .., SJOjel!polj:JUOJS 6~8'~ - gZ6 O'U ag'~ seu!wejs!lj!luV Lv9'0 ~ - zgf'g g'8~ g ~ V's SlN38V AClOl VClldS3Cl '" - '" .., ", sjue5e SNJ snoauella:Jsllf'J Zgot - Ov ~'~ n~ 960'~ eupdezueqopAJ vgg'g - S90'Z nz ~ ~ st 10PoJdospeJ VLO'6 - ~LO'g n~ lLO'L sjuexeleJ epsnlf'J ", - .., .., .., s:J!jeljjseue leJaue8 .., - '" 6'~S .., sjue5e UOSUI~Jed-!jUV '" - '" '" '" sjue5e 05!jJeA!jUe/:l!jewenUV ~~g'g~ - Svg'6 n~ OBg'Z ~ sjUeSlnAuo:JljUV SgO'~ - ~g~ g' ~8 vgg sjue!xeJouv 9Zn - v~~ Dv 0~6 V IN suo!jeu!qwo:J :J!se5IeUIf '" - '" .., .., lopew eJj- u e4do U! w eja:JV SBQ'z - ggg g'9Z lL8'~ 10peweJl ~~g'~ - g~6 g,€~ 6~n suo!jeu!qwo:J/lopeWeJl L9S'6~ - LgL'O~ ~'6 ~ ~ t'g~ su one U!q W O:J /u e ljdo U! w eja:J1f 9L8'~8 - L9t'U 86 ~L8'a SUO!j8U!qwo:J/s:J!sa518U8 snoau8I1a:JS!lf'J punoq - punoq (3SCl) JOJJa Jaddn JaMOl PJ8PU81S vnS1!S!A ~ s5nJp pal:Jalas pue ,(J05aI8:J 5nJO aA!lelaCl pa18W!IS3 leAJalu! a:Juapiluo:) %96 900~ :Sldwane apP!ns (p8nul~U08) 9~ Ellqel " Table 17 Suicide attempts, by patient and visit characteristics: 2006 Patient characteristics Estimated Visit characteristics Estimated visits1,2 visits 1,2 Total drug-related ED visits, suicide 182,805 altem pts Gender Number of drugs involved Male 71,657 Single drug 64,143 Female 111,137 Multiple drugs 118,661 Unknown ." Age Disposition 0-5 years ." Treated and released 31,528 6-11 years ". Discharged home 25,149 12-17 years 20,506 Released to police/jail 2,080 18-20 years 14,232 Referred to detox/treatment 4,299 21-24 years 18,855 Admitted to this hospital 101,409 25-29 years 21,877 ICU/critical care 37,821 30-34 years 17,095 Surgery ". 35-44 years 44,237 Chemical dependency/detox ". 45-54 years 32,970 Psychiatric unit 32,682 55-64 years 8,462 Other inpatient unit 30,129 65 years and older 4,352 Other disposition 49,867 Unknown ". Transferred 45,234 Race/ethnicity Left against medical advice 458 White 114,972 Died ... Black 28,491 Other ." Hispanic 18,058 Not documented 1,747 Race/ethnicity not tabulated above 2,095 (NTA) Unknown 19,188 1 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. 2 Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). After accounting for population size and the margin of error, the rate of drug-related suicide visits for females (73 visits per 100,000 population) was higher than that for males (48 per 100,000) (Figure 6). In general, the rates for patients aged 18 to 54 exceeded the rates for younger and older age groups. The rate for patients aged 12 to 17 (81 visits per 100,000) exceeded the rates for patients aged 55 and over. DAWN, 2006: NATIONAL ED ESTIMATES 53 " S31lfWIlS3 03 llfNOlllfN :900Z 'NMlfO 1>9 '%1717 paSeaJ:JU! 4:J!4M 'S:J!sa5IeUe p!o!do/ale!do pue '%9t paSeaJ:JU! 4:J!4M 'sauldazelpozuaq se 4:Jns 'Sldwane aPP!nS U! pa^IO^UI AIlUanbaJ~ s5nJp a41 JO awos JOJ 900G 01 1700G WOJJ luapl^a aJaM saseaJ:Jul '(8 ~ alqel) 900G 01 900G WOJJ papalap seM aseaJ:Jul ue lnq '900G 01 1700G WOJJ SId wane applns palelaJ-5nJp JOJ SI!S!^ 03 U! a5ue4:J lue:J!Jlu5!s ou seM aJa41 'lIeJa^o (9 ~ alqel) 900(; pue 'gOOl 'POOl :sJ!S!^ 03 ldwane apP!ns 'UMou~un seM A1P!U41a/a:JeJ 'SI!S!^ JO %0 ~ U! :elep 5u!sslw Aq papadw! S! sdnoJ5 A1P!U41a/a:JeJ a41 ~o sapuanbaJJ a^ljelaJ a41 5u!lenle^:J 'al14M aJaM 04M slualled pa^IO^U! sldwane apP!ns a41 JO %t9 'A1P!U41a/a:JeJ JO SWJal UI '(elE?pdn 800mo) 900G '~JOMleN 5UIUJE?M esnqlf 5nJO 'lfSHVlJIfS 'selpnlS pe!lddlf )0 eO!IIO :3:)Clnos <J1 .j:> w W N N m <J1 '" '" C> U'> 00 ~ ~ awwa::l alE?L^J U'> '" U, L. W N N N ? + .j:> .j:> .j:> .j:> u:> .j:> C> -..J ~ U'> 0 0 .~ "" "" ~ ~ os rt> os rt> -0 -0 0; 0; C> c; C> C> f.L 0 0 C> C> C> C> -0 -0 0 0 OOl -g OOl -g ~ ~ 0' o' ::J ::J OSl os l 900Z :Japua6 pue a6e Aq saleJ l!S!^ Q3 'sldwane ap!:>!ns 9 aJn6!::1 .. Table 18 Suicide attempts: 2004, 2005, and 2006 Drug category and selected drugs 1 Estimated visits2,3 Percent change4 2004 2005 2006 2004,2006 2005,2006 Total drug-related ED visits, suicide 161,586 151,568 182,805 21% altern pts Major substances of abuse Alcohol 48,726 47,891 54,820 Alcohol in combination 48,080 46,806 54,337 Alcohol alone 646 1,085 483 Cocaine 19,520 19,628 26,510 Heroin 4,579 3,167 4,265 35% Marijuana 12,074 11,955 15,272 Stimulants 4,535 5,410 4,829 Amphetamines 1,560 1,646 2,228 Methamphetamine 3,136 3,853 2,877 MDMA (Ecstasy) ... 529 1,239 GHB ... ... ... Flunitrazepam (Rohypnol) ... ... ... Ketamine ... ... ... LSD ... ... ... PCP ... ... ... Miscellaneous hallucinogens ... ... ... Inhalants ... 794 ... Combinations not tabulated above (NTA) ... ... ... Other substances PSYCHOTHERAPEUTIC AGENTS 88,034 82,144 106,128 29% Antidepressants 33,366 27,086 36,677 MAO inhibitors ... ... ... SSRI antidepressants 18,513 13,377 16,973 Tricyclic antidepressants 3,555 3,008 4,681 Miscellaneous antidepressants 3,337 2,681 3,806 Antipsychotics 17,807 17,129 22,491 Anxiolytics, sedatives, and hypnotics 52,653 52,022 68,177 29% 31% Barbiturates 1,949 1,219 2,031 Benzodiazepines 36,995 35,676 50,431 36% 41% Alprazolam 11,354 14,530 15,633 Clonazepam 9,403 9,064 14,173 56% Diazepam 4,630 3,968 599 DAWN, 2006: NATIONAL ED ESTIMATES 55 " S31VVolllS3 a3 lVNOI1VN :900;: 'NMVa 99 OOV'S Sv9'v ~ ~t9 SUO!jeu!qwoOjSajelA:l![ es 9US vltt Ssn uaxoJdeN v90'l ~ U6'0~ 609'S ~ uaJoJdnql 9S6'S ~ W'V~ v~~'6~ sjuaoe AJOjeWweIJU!-llue lep!OJajsuoN ~ ~S'l 6l~ 'l SSS'~ suo!jeu!qwOOjaUa4dAXodoJd %SS lVS'L 6lG'V OVS'S suo!jeu!qwoojauopOOAXO ... O~n v~L suoljeU!qwoojau 14dJolAJ lLL'~ 96S' ~ LStf auope4jalAJ ... ... ,.. suo!jeulqwoojaul ppadalAJ 19l ... ... SUOljeU!qwOOjaU04dJowoJ PAH S66'S SSO'L vSO'L suo!jeulqwoojauopoooJ PAH ... ... ... suoljeu!qwOO/lAUejUa.:! 6vS'l 9S9'l OSL'f suo!jeu!qwoojau!apoJ ... ... ... S uOlje U!q W DO jau! 4 dJ ouaJd ns %LS %SV OLnl fOS'U Sl6'9f SO!SaOleUe oljooJeN 6lf't 6~S'l S9t'l pa!lpadsun 'SP10!dojsaje!do %VS %vv SS ~'a 6SS'Ol 6S6'Sf SP!Oldojsaje!do ... V~S LOS SJOj!qI4U! l-xoJ '" ... ... sjuaoe au!eJO!WljUI;f %Sl Sl9' L9 SSS'VS S60'~9 sOISaO[eUI;f %vl It'V'lS flS'99 6V6' tL SlN381;f lAJ31SASSnO^~3Nll;f~lN3J SS9 SfS ... ajep!Ua4dlA4jalAJ '" ... ... aUlWeja4dweoJjxao ... OSv ... au!aJjeJ 6C;C; ... ... au lWeja4dweoJjxap-aU!Weja4dw\f 6v6'f lSn VS9'f SjUelnW!jS SNJ 90n m'l 6SS'f SON SO!jOUdA4 pue 'Sa^ljepaS 'SO!jAIO!XU\f vL9'9 GL6'v SSn wapldloz 9S6'f S6n 9vt'l aU!ZAXOJpAH 9SL'L SSS'9 SWL au!WeJpA4Ua4d!o as' ~l GlS'U 06L'9 ~ SOljoudA4 pue 'sa^!jepas 'SO!jA[O!XUe 'OS!lAJ OSO'L SVt't 9ln SON sau!daZelPozuas lS9'9 lSf'S S90'9 wedazeJOl 900l'900l 900l'vOOl 900l 900l vOOl ~ sonJp papalas pue AJOOajeo onJO vaflue40 juaoJad 8,zSj!S!^ pajew!js3 900l pue '900l 'POOl :Sldwane ap!::>!ns (penuljU08) IH alqel Table 18 (continued) Suicide attempts: 2004,2005, and 2006 Drug category and selected drugs 1 Estimated visits2,3 Percent change4 2004 2005 2006 2004,2006 2005,2006 Miscellaneous 22,864 22,692 27,371 an a Ig esics/ combi nations Acetaminophen/combinations 20,701 21,017 25,312 Tramadol/combinations 1,742 1,515 1,719 Tramadol 1,528 1,079 1,372 Acetaminophen-tramadol ... ... ... Analgesic combinations NT A ... ... 920 Anorexiants '" ... 654 Anticonvulsants 10,957 9,389 12,580 Antiemetic/antivertigo agents ... ... ... Anti-Parkinson agents 80 543 ... General anesthetics ... ... ... Muscle relaxants 5,921 5,785 7,072 Carisoprodol 1,864 2,038 3,811 Cyclobenzaprine 2,966 2,784 2,096 Miscellaneous CNS agents ... ... ... RESPIRATORY AGENTS 8,361 7,662 8,415 Antihistamines 2,059 1,650 1,627 Bronchodilators ... ... ... Decongestants ... '" 1,347 Expectorants ... 474 1,068 Upper respiratory combinations 4,818 4,207 3,982 Respiratory agents NT A ... 1,244 660 CARDIOVASCULAR AGENTS 7,667 5,814 7,965 Antiadrenergic agents, centrally acting 995 912 1,929 Beta-adrenergic blocking agents 2,105 1,916 1,999 Calcium channel blocking agents 879 193 1,040 438% Diuretics ... 539 ... Cardiovascular agents NTA 3,661 3,024 3,298 1 The classification of drugs used in DAWN is derived from the Multum Lexicon, @2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at http://www.multum.com. 2 These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. 4 This column denotes statistically significant (p < 0.05) increases or decreases between estimates for the periods shown. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 57 ~ S31V~11S3 03 lVNOIlVN :90Ol 'NMVO 89 'UMou~un seM Ajp!U4l8/a::leJ Sj!S!^ JO %6 U! :ejep 5u!ss!w Aq papadw! S! sdnoJ5 Ajp!U4ja/a::leJ a4j JO sapuanbaJJ a^!jelaJ a4j 5u!jenle^3 'aj!4M aJaM 04M sjua!jed pa^lo^u! SjIS!^ xOjap 5u!~aas JO (%69) Ajpo[ew a4j 'Aj!::llU4ja/a::leJ JO SWJaj ul '(UO!jelndod OOO'OO~ Jad a) salewaJ JOJ je4j ue4j Ja45!4 seM (uo!jelndod OOO'OO~ Jad ~9) salew JOJ SjlS!^ xOjap 5u!~aas JO ajeJ a41 'a5ueJ VV OJ IH a4j U! sdnoJ5 a5e lie SSOJ::le Jel!w!s aJaM Sj!S!^ xOjap 5u!~aas JO sajeJ a4j 'juno::l::le OjUl JOJJa JO u!5Jew a4j pue az!s uO!jelndod 5u!~e1 'aw04 OJ pa5Je4::lSlP aJaM Aa4j asne::laq j45nos Aa4j aJe::l a4j pa^la::laJ a^e4jou Aew sase::l xOjap 5u!~aas JO (%a) JajJenb auo jnoqe 'Ja^aMOH ,(OZ alqe1) Aj!l!::leJ aJe::l 4jlea4 Ja4joue OJ JaJsueJj JO 'Sa::l!MaS juawjeaJj asnqe a::luejsqns JO xOjap JOJ aJa4Masla leJJaJaJ 'UO!ss!wpe jua!jedu! Ja4j!a 'aJe::l dn-MolloJ JO adAj awos pa^!a::laJ (%69) 0 ~ JO jno L Apeau 'Sj!S!^ 03 xOjap 6ul~aas a4j 5uow\;l 'juanbaJJ jSOW aJaM suo!jeu!qwo::l/auOpO::lAXO pue suo!jeu!qwO::l/auopo::lOJPA4 'splo!do/saje!do a4j5uow\;I 'alqejou aJaM '(%9Z) s::l!sa5IeUe p!o!do/aje!do Alpewpd aJaM 4::l!4M 'sjua5e SNJ pue '(%8) sau!daze!pozuaq AI!Jewpd aJaM 4::l!4M 'sjUa6e ::l!jnadeJa4j04::lASd 'Sle::l!jna::leWJe4d a4j 5uow\;I '(Sj!S!^ JO %L) sjUelnW!jS aU!Weja4dwe4jaW JO aUlWeja4dwe pue (Sj!S!^ JO %6~) euen[pew Aq paMolloJ 'AljUanbaJJ jSOW paJJn::l::lo (Sj!S!^ JO %6Z) U!oJa4 pue (Sj!S!^ JO %6v) aUle::lo::l 's5nJp PII! a4j 5uow\;I 's5nJp Ja4jo 4j!M UO!jeulqwO::l U! 1040::lle AIUO sapnpu! S!4j Japlo pue ~Z pa5e sjlnpe JOJ asne::laq 'aJa4 pajuasaJdaJJapun aq Aew 1040::lle JO aloJ a4j 'Ja^aMOH '(6 ~ alqe1) 1040::lle pa^IO^u! Sj!Sl^ 03 xOjap 6u!~aas lie JO (%OV) PJ!4j auo ue4j aJOW pue 's5nJp ald!llnw pa^lo^u! Sj!S!^ 03 xOjap 5ul~aas a4j JO (%99) SPJ!4j OMj ApeaN 'Sa::l!MaS asa4j JOJ puewap a4j JO juajxa IInJ a4j ssedwo::lua JOU saop ajew!jsa S!4j 'aJoJaJa41 'jej!ds04 a4j U!4j!M sj!un juaWjeaJj asnqe a::luejsqns JO xOjap OJ UO!ss!wpe JOJ 03 a4j U! a::lueJeap le::l!paw aJ!nbaJ je4j Sa::llpeJd a^!jeJjSlU!Wpe 4j!M Slej!ds04 U! pajeJjua::lUO::l aq OJ puaj Sj!S!^ "xojap 5u!~aas" asa41 '900Z 5upnp Sa::llMaS juaWjeaJj asnqe a::luejsqns JO uO!je::ly!xojap 5ul~aas sjua!jed JOJ SI!S!^ 03 pajelaJ-5nJp (OV9'9V~ OJ ~H'06 :IJ) 99t'9 ~ ~ sajeW!jsa NM\;IO (L a.m6!.:1 'OZ-S ~ salqel) xOlap 6uPlaas Table 19 Seeking detox: 2006 Relative 95% Confidence interval Estimated Drug category and selected drugs 1 visits2,3,4 standard Lower Upper error (RSE) bound - bound Total drug-related ED visits, seeking detox 118,355 12.1 90,171 - 146,540 Marijuana Stimulants Amphetamines Methamphetamine MDMA (Ecstasy) GHB Flunitrazepam (Rohypnol) Ketamine Major substance of abuse 47,102 14.3 33,887 60,316 46,769 14.3 33,646 59,892 57.5 92,385 12.6 69,548 115,223 57,738 14.1 41,815 73,661 34,462 14.6 24,611 44,312 22,104 16.4 14,983 29,226 8,128 26.2 3,955 12,301 2,034 26.1 993 3,074 6,211 31.2 2,407 10,014 483 35.7 145 821 Alcohol Alcohol in combination Alcohol atone Non-alcohol illicits Cocaine Heroin LSD PCP 989 54.3 41.5 184 1,794 Miscellaneous hallucinogens Inhalants Combinations not tabulated above (NTA) 50.3 The classification of drugs used in DAWN is derived from the Multum Lexicon, @ 2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at http://www.multumcom. These are estimates of ED visits based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. 3 Estimates are all expressed in visits. Visits cannot be summed across drugs because drug-related visits often involve multiple drugs. 4 Three dots (...) indicate that an estimate with an RSE greater than 50% or an estimate less than 30 has been suppressed. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 59 S31'v'Vol11S3 03 l'v'NOIl'v'N :900l 'NM'v'O 09 '(aj8pdn BOOmO) 900<: '~JOMjaN 5U!UJ8M asnq'v' 5nJO 'V'SHVIJ'v'S 'Sa!pnlS pa!ldd'v' )0 a~!JjO :3::nlnOS 'passaJddns uaaq s84 OE U84j ssal aj8W!jSa U8 JO %OS U841 Jal8aJ5 3SCl U8 41!M al8W!lsa U81841 eI8~!pU! ("..) SloP eeJ41 G 'se181S pel!Un e41 U! s03 Jn04-\7<: 41!M S18j!ds04 A8jS-jJ04S '18Jape,j-uou)0 aldw8s e^!j81UeseJdeJ 8 UO pes8q SI!S!^ 03)0 sel8W!ISe eJ8 ese41 ~ L06'0 ~ UMOU~Un LU (V1N) e^oq8 pelelnqellou A1P!U41e/e~eCl w; paluawn~op JON L6E' ~ ~ ~!ueds!H LW~ Ja4jO BW9<: ~~eI8 ... palO L9B'69 al!4M L\76' ~ a:l!^pe le~lpaw ISU!e5eual Aj!:l!U4ja/a:leCl 6\70'0~ paJJa)sueJ 1 '" UMOU~Un 9 ~0'\7~ UO!I!sods!p Ja4jO ~B9 Japlo pue SJeaA 99 69B'1> jlun jua!jedu! Ja410 ~1:9'1> SJeeA 1>9-99 G06'9 I!Un ~!Jle!4~ASd Gi:t1:1: SJeaA 1>9-91> 01>9'Gi: xOlaP/A~uapuadap le~!wa4J 999' 9E SJeaA 1>1>-9E ... AJa6JnS 66L'G ~ SJeaA 1>E-OE L6B aJe~ le~!jIJ~JnJI 1>OB'n SJeaA 61:-91: BLt9E lej!ds04 S!4j OJ pajjlwpv 9E ~ ' ~ ~ SJeaA 1>1:- ~1: 1:VB'SE luawjeaJl/xOjap 01 paJJa)aCl L9L'B SJ8aA O<:-B ~ ~6L l!e[/a~!Iod OJ paS8alaCl 69L't SJeaA n-u OEV'1:E aw04 pa6J84~S!0 ... SJeaA ~ ~ -9 E90' 69 pasealaJ PU8 paleaJ 1 '" SJeaA S-O uO!l!sods!O allv ... UMOU~Un 1:EV'LL s6nJp aldljlnV'J B<:9'~1> alewa::J 1>1:6'01> 6nJp al6u!s 699'9L a18V'J pa^lo^u! s6nJp JO JaqwnN J8pU8E) 99E'B ~ ~ xOjap 6U!~88S 'Sj!S!^ 03 P8jel8J-llnJp lej01 nSj!S!^ s~!lspaj:leJe4:l j!S!^ nSj!S!^ s:l!lsp8peJe40 jU8!jed p8jew!js3 pajew!js3 gOal :s~!ls!Jal~eJe4~ l!S!^ pue lua!led ,(q 'xolap 6uptaas Ol alqel Figure 7 Seeking detox, ED visit rates by age and gender: 2006 150 150 c: c: 0 0 '';::; '';::; m m ~ 100 ~ 100 0 84 85 0 0.. 0.. '" '" '" '" '" '" 6 6 '" '" OJ 51 OJ 51 0.. 50 0.. 50 B ClJ m ro 0:: 0:: 14 2 0 0 Lr> r-. '" "'" O"l "'" "'" "'" "'" + Male 6 N ~ N M "'" Lr> 'f Lr> cO N 00 J., 6 J., J., Lr> \.0 N N M M "'" Lr> 27 fl Female SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update), DAWN, 2006: NATIONAL ED ESTIMATES 61 .. S31VWIlS3 03 lVNOllVN :900Z 'NMVO <:9 '(alepdn BOOlIEO) 900l '~10MlaN 6UIU18M asnqv 6n10 'VSHl^J\lS 'SalpnlS pa!ldd\l )0 a:JIIIO :3:>~nOS 'UMO~S spo[1ad a~l 10) SaI8W!ISa uaaMjaq SaSeal:Jap 10 SaS8al:JUI (90'0> d) lU8:J!)IU6IS AII8:J!IS!lels salouap uwnlo:J sl~l p 'passalddns uaaq se~ DE ue~l ssal alew!lsa ue 10 %09 u8~1 lal8a16 3S~ ue ~1!M alewllsa ue le~l aI8:JIPU! (,,,) SlOP aal~l E 'salelS pallun a~l uI s03 lno~-vl ~1!M SI81!dso~ A81S-jJO~s 'lelapa::l-UoU)O aldwes aAI181uasaldal e uo paseq SllslA 03)0 salewllsa aJe asa~l Z 'wo:Jwnllnw'MMM/ldll~ Ie laulalul a~l uo puno) aq ue:J pue \I xIPuadd\l uI pap!AoJd S! uo:J!x87 a~I)O asn 6ululaA061uawaa16\1 6u!sUa:l!1 wnllnl^J a~l '(LOOl) slUaWal!nbaJ anb!un s,NM\lO laaw 01 pa!)!pow seM UO!18:l!)lssep a~l ':lUI 'Sa:lIAJas UOI18WJO)UI wnllnl^J 'LOOl Q) 'uo:J!x87 wnllnl^J a~l W01) paA[1ap S! NM\lO uI pasn S6nlp)0 UO!18:JI)ISSep a~l ~ '" ~6 ~ '" ('dlN) aAoqe palelnqejjou SUO!jeulqwOJ '" '" '" sjuele~ul ", '" '" sua60ulOnlle~ snoauella:Js!l^J 6B6 6GL aB dJd '" '" ", OSl '" '" ", aUIWeja>l '" '" '" (loudA40tj) wedazeJj!Unl::l '" ", '" 8H8 EBv w; lBB (ASejs:J3) \ll^J0l^J ~ ~t9 '" '" aU!Weja4dwe4jal^J vEO'l '" '" saU!Weja4dW\I m'B GO V' 9 ~ 09L' ~ ~ sjuelnw!lS VO ~ 'll 9BV'll 996'9l euenfp8l^J 19V'VE 96B'Ov 9EO'Lv uloJaH BEL'L9 ~90'99 6B6'l9 aU!8:loJ '" '" '" auole 1040:J1\I 69L'9v v9~'Lv ~EB'~9 uOljeulqwo:J U! 10~0:J1\I lO~'Lv v6V'Lv 199't9 1040:J1\I asnqe )0 sa:Jue~sqns JOreL^) SSC'SH 9lz'9l ~ L98'~P~ xotap 6uPlaas 's~!s!^ 03 patelaJ-6nJp le~ol 9OOl'SOOl 9OOl'POOl 900l SOOl POOl pa6ue4:l ~ua:JJad t'ZS~!S!^ pa~ew!~s3 ~ s6nJp papalas pue ,{J06a~e:J 6nJO 900Z pue 'gOOZ '~OOZ :XOtap 6u!>taas ~Z alqel '(~G alqBl) Sj!S!^ asa4j U! pa^lo^U! s6nJp jlO!11! a4j JO 1040:>IB JOl JO 'IIBJaM Sj!S!^ 03 xOjap 6u!~aas JOl papajap aJaM '900G OJ 900G WOJl JO '900G OJ tOOG WOJ! Sj!S!^ 03 U! sa6uB4:> jUB:>!!!u6!s ON (~Z alqel) 900Z pue '900Z 'VOOZ :Sl!S!^ 03 XOlap 6u!)jaas Appendices DAWN, 2006: NATIONAL ED ESTIMATES 63 .. S31VVolI1S3 03 lVNOllVN :900l 'NMVO 179 ~ APPENDIX A MUL TUM LEXICON END-USER LICENSE AGREEMENT 1. Introduction A. This License Agreement (the "License") applies to the Multum Lexicon database (the "Database"). This License does not apply to any other products or services of Cerner Multum, Inc. ("Multurn"). A "work based on the Database" means either the Database or any derivative work under copyright law; i.e., a work containing the Database or a substantial portion of it, either verbatim or with modifications. A translation of the Database is included without limitation in the term "modification". Each end-user/licensee is addressed herein as "you". B. Your use of the Database acknowledges acceptance of these restrictions, disclaimers, and limitations. you expressly acknowledge and agree that Multum is not responsible for the results of your decisions resulting from the use of the Database, including, but not limited to, your choosing to seek or not to seek professional medical care, or from choosing or not choosing specific treatment based on the Database. C. Every effort has been made to ensure that the information provided in the Database is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive. D. Multum does not assume any responsibility for any aspect of healthcare administered or not administered with the aid of information the Database provides. 2. Terms and Conditions for Copying, Distribution and Modification A. You may copy and distribute verbatim copies of the Database as you receive it, in any medium, provided that you conspicuously and appropriately publish on each copy an appropriate copyright notice and disclaimer of warranty; keep intact all the notices that refer to this License and to the absence of any warranty; and give any other recipients of the Database a copy of this License (the readme.lxt file) along with the Database and anything else that is part of the package, which should be identified. B. You may modify your copy or copies of the Database or any portion of it to form a derivative work, and copy and distribute such modifications or work under the terms of Section 2.A. above, provided that you also meet all of these conditions: i) You must cause the modified files to carry prominent notices stating that they are derived from the Multum Lexicon database from Cerner Multum, Inc. and that you changed the files and the date of any change(s). ii) If you incorporate modified files into a computer program, you must cause it, when started running for interactive use in the most ordinary way, to print or display an announcement including an appropriate copyright notice, a notice that you have modified the Multum Lexicon database from Cerner Multum, Inc., and a notice that there is no warranty (or that you provide the warranty) and telling the user how to view a copy of this License. DAWN, 2006: NATIONAL ED ESTIMATES 65 , S31Vv.lllS3 03 lVNOllVN :900;: 'NMVO 99 "S:38\flt'J\f0 HJnS .:10 AllllSISSOd 3H1.:10 03SIAO\f N33S S\fH AlCl\fd tl3HlO AN\f tlO It'Jnllnlt'J .:II N3A3 '3lt'J11 NMOO tlO 'SS3NISnS .:10 SSOl 'Sll.:10tld .:10 SSOl tlO.:l S38\flt'J\f0 8NIOnlJNI 'S38\flt'J\f0 lJ3tllONI tlO 'l\f11N3n03SNOJ 'l\f1N30IJNI 'l\fIJ3dS AN\f tlO.:l 3lS\fll 3S '3AOS\f O3HIlt'Jtl3d S\f 3S\fS\f1\f0 3H131nSltl1SI03tl tlO/ON\f A.:IIOOlt'J A\flt'J OHM Altl\fd tl3HlO AN\f tlO 'It'Jnllnlt'J lllM (8Nl11tlM NI 01 033tl8\f tlO M\fl 3lS\fJlldd\f AS O3tlln03tl SS3lNn) 1N3A3 ON NI "S "NOllJ3tltlOJ tlO tll\fd3tl '8NIJIAtl3S Atl\fSS3J3N ll\f .:10 lS0J ON\f A1IlISISNOdS3tl3H13lt'JnSS\f nOA '31\ftlnJJ\fNI tlO '3Bldlt'JOJNI '3A11J3.:130 3AOtld 3S\fS\f1\f0 3H1 OlnOHS "nOA H11M SI3S\fS\f1\f0 3H1.:10 3JN\flt'JtlO.:ltl3d ON\f A11l\fnO 3H1 01 S\f >!Sltl3tl11N3 3Hl "3S0dtlnd tl\flnJI1tl\fd \f tlO.:l SS3N11.:1 ON\f A1IlIS\f1N\fHJtl3lt'J .:10 S311N\ftltl\fM O3lldlt'J1 3H1 '01 0311lt'JlllON 1ns '8NIOnlJNI '03 Ildlt'J I tlO Atl01nl\f1S '03SS3tldX3 tl3Hl13 'ONI>! 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AU8dwo::>::>\f (I :6U!MOII0! 841!0 8UO op OSl8 nOA 1841 P8PI^OJd 8Mq8 "S"G PU8 Y"?' sUOIpas!o sWJal a41 J8pUn WJO! p8po::>ua U8 uI ("S""?, UO!l::>8S Japun 'II uo p8S8q ~JOM 8 JO) 8S8q81eO 841 alnqplslP PU8 Ado::> Aew nOA "0a "as8q8180 a41 uo p8S8q S~JOM 8^IP8110::> JO 8^!le^p8p!0 uO!lnqpIS!p 84110JIUO::> 0114Bp a41 8SpJaXa 01 sl IUaIU! 841 'J8418J :noA Aq AI8JIIU8 U811IJM ~JOM 01 SI46p JnOA IS8IuO::> JO SI46p W!8P 01 UO!P8S S141!0 IU81uI 841 IOU sl II "J ~ " C. IN ADDITION, WITHOUT LIMITING THE FOREGOING, THE DATABASE HAS BEEN DESIGNED FOR USE IN THE UNITED STATES ONLY AND COVERS THE DRUG PRODUCTS USED IN PRACTICE IN THE UNITED STATES. MUL TUM PROVIDES NO CLINICAL INFORMATION OR CHECKS FOR DRUGS NOT AVAILABLE FOR SALE IN THE UNITED STATES AND CLINICAL PRACTICE PATTERNS OUTSIDE THE UNITED STATES MAY DIFFER SUBSTANTIALLY FROM INFORMATION SUPPLIED BY THE DATABASE. MUL TUM DOES NOT WARRANT THAT USES OUTSIDE THE UNITED STATES ARE APPROPRIATE. D. 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Aew wnllnV\lle41 aaJ6e no). <S -d APPENDIX B GLOSSARY OF TERMS This glossary defines terms used in data collection activities, analyses, and publications associated with the emergency department (ED) component of the Drug Abuse Warning Network (DAWN). Accidental ingestion: This category of drug-related ED visits includes those involving the accidental use of a drug, for example, childhood drug poisonings and individuals who take the wrong medication by mistake. Adverse reaction: This category of drug-related ED visits represents the consequences of using a prescription or over-the-counter (OTC) pharmaceutical for therapeutic purposes and includes visits related to adverse drug reactions, side effects, drug-drug interactions, and drug-alcohol interactions. Adverse reactions that involve a pharmaceutical with an illicit drug are exceptions that are excluded from this category. Alcohol only (age less than 21): This category of drug-related ED visits includes those in which alcohol was the only drug involved and the patient was aged less than 21. Although alcohol is an illegal drug for minors, combining these cases with other cases involving illicit drugs tends to mask rather than highlight their importance for prevention and treatment efforts. Most instances of alcohol as the only drug in patients under age 21 are classified in the alcohol only (age < 21) case type. However, some are classified as suicide-attempt or seeking detox, case types that precede alcohol only (age < 21) in sequence. Case description: A description of how the drug(s) was related to the patient's ED visit. The case description, in conjunction with other documentation in the ED medical record, is used to determine if the ED visit is reportable to DAWN. It is copied verbatim from the patient's chart when possible. Case type: See Type of case. Case type other: See Drug misuse and abuse. Confidence interval (CI): An interval estimate, that is, a range of values around a point estimate that takes sampling error into account. Ninety-five percent is an accepted standard of confidence. Technically, a 95% CI means that, if repeated samples were drawn from the same population of hospitals using the same sampling and data collection procedures, the true population value would fall within the confidence interval 95% of the time. Practically, a 95% CI summarizes both the estimate and its margin of error in a straightforward way with a reasonable degree of confidence. Calculation of 95% Cis is discussed in Appendix C. Diagnosis: The condition(s) for which the patient was treated as determined by the clinician after study. Disposition: The location or facility to which an ED patient was referred, transferred, or released. DAWN, 2006: NATIONAL ED ESTIMATES 69 i- .. S31V~11S3 03 lVNOI1VN :900<: 'NMVO OL 'UO!lea!!!Ssep !O sasodJnd JO.::J 'asnqe !O aauelsqns Jo[ew e se aauelJodw! 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'weJ60Jd xOlap JO luawleaJl asnqe aauejsqns e OJ paJJa!aJ seM jua!jed a4jje4j saje::>!pu! lJe4::> a41-JuewJeeJJ/XoJep oJ peJJejeCj III /!e!leaf/od oJ peseeleCj II . 4lJO! os pue '6u!^ejs aJe ^a4j JaAaJa4M JO laj04 J!a41 ueaw ^ew j! 'peOJ a41 uo ~::>!S la6 04M sJalaAeJl JO! :^I!SJaA!un J!a4j sueaw aw04 'san!SJaA!Un ^qJeau je sjuapnjs JO! 'JaAaM04 :^lIe::>OI aA!1 04M aldoad JO! pasn ^lIeJaua6 S! awoH 'aauaPlsaJ S,juaned a41 OJ pa6Je4aS!p ueaw 01 ^J06ajea peoJq e se pasn S! "awoH,,--ewolj p86JeljasJG III :sap06ajea aaJ4j sapnpu! pasealeJ pue peJeeJl ~ {) "amphetamines" (plural) includes a class of compounds derived from or related to the drug amphetamine. Although some "designer" drugs fall into the class of amphetamines, we choose to report some of them individually as major substances of abuse (e.g., methamphetamine). This category does not include other CNS stimulants, such as caffeine or methylphenidate. l1li Combinations not tabulated above (NTA)- This category includes combinations composed of two or more major substances of abuse that are mixed and taken together. For example, "speedball," which usually refers to the combination of heroin and cocaine taken at once, would be classified as a combination NTA, whereas heroin and cocaine used separately would be classified separately in the categories heroin and cocaine. Combinations consisting of a major substance of abuse and another substance are classified in the category of the major substance (e.g., heroin with scopolamine is classified as heroin). III Inhalants-This category includes anesthetic gases and psychoactive non pharmaceutical substances for which the documented route of administration was inhaling, sniffing, or snorting. Psychoactive non pharmaceuticals fall into one of the following three categories: (1) volatile solvents-adhesives (model airplane glue, rubber cement, household glue), aerosols (spray paint, hairspray, air freshener, deodorant, fabric protector), solvents and gases (nail polish remover, paint thinner, correction fluid and thinner, toxic markers, pure toluene, cigar lighter fluid, gasoline, carburetor cleaner, octane booster), cleaning agents (dry cleaning fluid, spot remover, degreaser), food products (vegetable cooking spray, dessert topping spray such as whipped cream, whippets), and gases (butane, propane, helium); (2) nitrites-amyl nitrites ("poppers," "snappers") and butyl nitrites ("rush," "locker room," "bolt," "climax," "video head cleaner"); or (3) chlorofluorohydrocarbons (freons). Anesthetic gases (e.g., nitrous oxide, ether, chloroform) are presumed to have been inhaled. III Stimulants-This category includes amphetamines and methamphetamine. Since some drug screens test for amphetamines only as a class, an amphetamine-positive result could indicate amphetamine or methamphetamine. For this reason, amphetamines and methamphetamine are combined for analysis into the category "stimulants." This category does not include other CNS stimulants, such as caffeine or methylphenidate. Drug misuse and abuse: A group of ED visits defined broadly to include all visits associated with illicit drugs, alcohol use in combination with illicit drugs or alcohol alone among those younger than 21 years, and nonmedical use of pharmaceuticals. Nonmedical use of pharmaceuticals includes prescription and OTC pharmaceuticals in ED visits that are of the following case types: III Overmedication- This category was designed to capture nonmedical use, overuse, and misuse of prescription and OTC medications that are not documented as drug abuse in the medical chart. III Malicious poisoning-This category was designed to capture cases of drug use in which the patient was administered a drug by another person for a malicious purpose. Drug-facilitated sexual assault is one type of malicious poisoning, but other types of malicious poisonings, such as product tampering, would be classified in this category as well. III Case type Other-This category includes all drug-related ED visits that could not be assigned to any of the other seven types. By design, most cases of documented drug abuse will fall into this category. Drug-related ED visit: Any ED visit related to recent drug use. This is the definition of a DAWN case effective January 1, 2003. To be a DAWN case, a drug needs only to be implicated in the visit; the drug does not have to have caused the visit. One patient may make repeated visits to an ED or to several EDs, thus producing a number of visits. The number of unique patients involved in the reported drug-related ED visits cannot be estimated, because no direct patient identifiers are collected by DAWN. DAWN, 2006: NATIONAL ED ESTIMATES 71 ~ ,. S31VVlI1S3 03 lVNOllVN :900Z 'NMVO ZL 'a::>8J JO SSalPJ85aJ 'U!5pO JO aJnlln:J 4S!U8dS Ja410 JO 'U8::>paW\f 18JlUaJ JO 41noS 'U8::>!tJ ojJand 'U8::>!XaV'J 'u8qnJ JO uosJad \f-oUne7 JO :J!ueds!H III '8::>pN JO sdnoJ5 18P8J ~::>8Iq a41 JO AU8 U! SU!5pO 5U!A84 uosJad \f-ue:JfJaw'tj ue:JfJJ'tI JO >/:Je/8 III '8::>!JJ\7' 4jJON JO 'IS83 aIPP1V'J a41 'adoJn3 JO Saldoad 18U!5pO a41 JO AU8 U! SU!5pO 5U!A84 uosJad \f-aJilfM iii :SMOIIOJ S8 aJ8 SWJOJ UO!paIlO::> 818P NM\fO a41 uo Sap05a18::> AlP!U41a/a::>8J a41 'L66~ U! 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III American Indian or Alaska Native-A person having origins in any of the original peoples of North and South America (including Central America), and who maintains tribal affiliation or community attachment. III Native Hawaiian or Other Pacific Islander-A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. II Not documented-Used when documentation of race is not available from source records. Despite the detail allowed by these categories, race and ethnicity are often not documented with this level of specificity in patient/decedent records. As a result, categories used to tabulate race and ethnicity data in the publications are: II White-Anyone meeting the definition of white (above). Those who are identified as white and Hispanic are classified as Hispanic. II Black-Anyone meeting the definition of black or African American (above). Those who are identified as black or African American and Hispanic are classified as Hispanic. III Hispanic-Anyone whose ethnicity is Hispanic or Latino (above) is placed in the category Hispanic, regardless of race. III Race/ethnicity NTA- This includes those categories that are too small to report independently, including the following: two or more races, American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander. I!I Unknown-Racelethnicity is unknown. Those who are identified only as Hispanic are classified as Hispanic. Rate: A measure of the incidence of drug-related ED visits per 100,000 population. A rate can be calculated for the total population or for any subset defined by characteristics such as age and gender. Relative standard error (RSE): A measure of an estimate's relative precision. The RSE of an estimate is equal to the estimate's standard error (SE) divided by the estimate itself. For example, an estimate of 2,000 cocaine visits with an SE of 200 visits has an RSE of 10%. The larger the RSE, the less precise the estimate. Estimates with an RSE of 50% or greater are not published by DAWN. (See also Precision and Standard error.) Sampling: Sampling is the process of selecting a proper subset of elements from the full population so that the subset can be used to make inference to the population as a whole. A probability sample is one in which each element has a known and positive chance (probability) of selection. A simple random sample is one in which each member has the same chance of selection. In DAWN, a sample of hospitals is selected in order to make inference to all hospitals; DAWN uses simple random sampling within strata. Sampling frame: A list of units from which the ED sample is drawn. All members of the sampling frame have a probability of being selected. A sampling frame is constructed such that there is no duplication and each unit is identifiable. Ideally, the sampling frame and the universe are the same. The sampling frame for the DAWN hospital ED sample is derived from the American Hospital Association (AHA) Annual Survey Database. Sampling unit: A member of a sample selected from a sampling frame. For the DAWN sample, the units are hospitals, and data are collected for all drug-related ED visits at the responding hospitals selected for the sample. DAWN, 2006: NATIONAL ED ESTIMATES 73 e:. .. S31VI'lllS3 03 lVNOllVN :900l 'NMVO vL 'ldwene epP!nS :A4:JJeJe!4 5U!MOIIOJ e41 WOJJ se!ldde le411SJ!J e41 'AJ05ele:J euo AIUO pue euo OIU! pepo:J S! ese:J 4:Je3 "SI!S!^ 03 peleleJ-5nJp lie JO lflS eSJe^!p e41 WOJJ sese:J NMlfO JeI!W!S dnoJ5 01 pesn UO!le:J!J!ssel:J If :eSB:J JO edA1 "edAl ese:J Je410ue 01 peu5!sse eJe 'Jles "WJe4" 01 sldwene 5u!pnpu! 'UO!leep! 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The rules for assignment of DAWN cases to types of cases are defined in the DAWN ED decision tree in Appendix C. Universe: The entire set of units for which generalizations are drawn. The universe for the DAWN ED sample is all non-Federal, short-stay, general medical and surgical hospitals in the United States that operate one or more EDs 24 hours a day, 7 days a week. Specialty hospitals, hospital units of institutions, long-term care facilities, pediatric hospitals, hospitals operating part-time EDs, and hospitals operated by the Veterans Health Administration and the Indian Health Services are excluded. The universe of EDs is identified from the American Hospital Association's Annual Survey Database. DAWN, 2006: NATIONAL ED ESTIMATES 75 76 I DAWN, 2006: NATIONAL ED ESTIMATES o o .t APPENDIX C DAWN DATA COLLECTION AND STATISTICAL METHODS Introduction The Drug Abuse Warning Network (DAWN) is a public health surveillance system that has monitored drug- related emergency department (ED) visits to hospitals since the early 1970s. DAWN was initially established by the Drug Enforcement Administration. Then DAWN was transferred to the U.S. Department of Health and Human Services (USDHHS), where the National Institute on Drug Abuse (NIDA) conducted DAWN from 1980 to 1992. Since 1992, the Office of Applied Studies (OAS) of the Substance Abuse and Mental Health Services Administration (SAMHSA), USDHHS, has been responsible for DAWN operations and reporting. Since its inception, DAWN has relied on data collected from a sample of hospitals. However, over the years, the exact survey methodology has been adjusted to improve the quality, reliability, and generalizability of the information produced by DAWN. When NIDA assumed responsibility for DAWN in 1980, implementation of a sample of hospitals to produce representative estimates for the Nation and for selected metropolitan areas became a priority. This sample, refreshed with annual maintenance, continued to support DAWN estimates for the coterminous United States and 21 metropolitan areas until 2002. By that time, major population shifts and changes in the hospital industry over the preceding two decades made apparent the need for a redesign of the sample of hospitals, which was undertaken as part of a wholesale redesign of most major features of DAWN. Currently, the DAWN survey relies on a longitudinal probability sample of hospitals located throughout the United States, including Alaska and Hawaii. Hospitals eligible for selection into the DAWN sample must be non-Federal, short-stay, general surgical and medical hospitals located in the United States, with at least one 24-hour ED. This current approach was first implemented in the 2004 data collection year. DAWN uses the data from the visits classified as DAWN cases in the selected hospitals to calculate various estimates of drug-related visits for the Nation as a whole, as well as for specific metropolitan areas. To calculate these estimates and measure their precision, the DAWN survey requires the application of sampling and weighting methodologies. This appendix documents the data collection methods and the sampling, weighting, and variance estimation methodologies used to develop estimates for the DAWN data collected for 2004, 2005, and 2006. Target population The target population is drug-related ED visits in non-Federal, short-stay, general surgical and medical hospitals in the United States with at least one 24-hour ED. Hospital sample frame DAWN uses the American Hospital Association (AHA) Annual Survey Database as the basis for its sampling frame. The AHA maintains an updated national registry of U.S. hospitals that is estimated to have a coverage rate of DAWN, 2006: NATIONAL ED ESTIMATES 77 'lo S31'v'~11S3 a3 1'v'NOI1'v'N :900l 'NM'v'a 'ilL "9090911 'o6e~!~:) 'laaJIS U!I~UeJ::l ~jJoN aUQ tOOl 1~6!J"do:) ':)11 wnJo::l ~lleaH ~OOl Jea" le~s!::l 'aseqelea "aAJns lenuu'v' 'v'H'v' ~ '~J aln6!.::J U! pap!^old S! SWal! elep NMVO papallo:) a41lle 6U!M04S W10J jlOdal ase:) a41 NM'VO Aq papallo~ SWal! eleo 'SI!S!^ 03 JO aSla^!Un a41 6U!Ma!^al U! ssa1601d 1!a41 '601 UO!lells!6al 03 a41 JO ^do:) e uo '~:)ell oSle slajlodaCj NMVO 'e!lal!l:) uo!palas ase:) :)~pads a41 Slaaw le411!S!^ 03 4:)ea 10J WalS^S NMVO a41 01 jlOdal ase:) :)!uolpala ue Sl!wqns lajlodaCj NMVO a41 'asn 6nlp 01 pajelal SI!S!^ 03 PU!J 01 SPlo:)alle:)!paw lie SMa!^allajlodaCj NMVO paleu6!sap a41 'NMVO U! 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J! awelJ 6u!ldwes NMVO a41 U! uo!snpu! 10J alq!6!1a aq 01 palap!Suo:) S! lel!ds04 V 'SUO!leZ!ue610 aleJ 41leaH JO UO!lel!pal:):)V uo UO!SS!wwoJ lU!Or a41 se 4:)ns SUOneZ!Ue510 ^q uO!lel!pal:):)e pue :uels le:)!paw pasua:)!1 ~SUO!I!puo:) le:)!paW :)!Jpads 10 lelaua6 10J ':)!lnadela4110 :)!ISou5e!p 'sa:)!~as lUa!led JO UO!S!^Old a41 apnl:)u! asa41 'VHV a41 ^q lel!ds04 e se pa!J!Ssep aq 01 e!lal!l:) lelaMS laaw lsnw UO!leZ!ue510 ale:) 41lea4 V ~'%66 .. Figure C1 DAWN ED case form f2Ay~R~ ABUSE WARNINC NETWORK 1. Facility o::IJIDJ GMll Nv. 0'13Q-{)(ilfJ ~"l1ir,,> lZ13112008 Emergency Department Case Report u.s. Depal1ment of Health and Human Sef'Ji((~s . Substance Abuse and Menti11 Health Service:> Administration 2. Date of Visit OJ OJ L2.\(S;r: 0 . ,"i;j";:;:,..u:;I,;:'~0;<, 5. Patlent'sl~"')'lomc,'lIP ~d~\ /.1/ ,,' ,.,"" :; '}:. I ,.:*V,,::"~1.. ".,;:;, C::;;' I" ~" <::~.,~>> fl "~., OtherwjSt..~~/"€,'~,:~~n",,e "':':'ponse:,1I ',I o N.o fixed ~';~,~~re;<>{e.g. homeless~ 1/ o I nstit.ution (~~~1",,~(.~~lter I j a i I/hos~:;ta IlJl;;:;::::;:;;;::';:,\~. o OutsIde u.s. ,"::' :~:;::::::'::; -:::;:J 1.:::::.,;,:::::::::::::;;;;:::-" o Not documented ~ ,,"'"""r;""1" DI(" :''''''~ "~ll 1"'1 Ii // J~' 8. Diagnosis List up to 4 dia~Sof1s noted)::;;ff;:~~~nt0},art. Do not list/CD codes. ':.1 ':I;~"~~,,(~;V JL i\ 3. v ,,_ 'V i ,//./4. '~( // .//7,,;;;: 9. Case Description Beginning with the pres/4tjn,f/comp/;::i~t, d/[<ri<~ how the drug{s) was related to the ED visit, \,:\ f ".,-:/'" "~I / "./ "-"'<\ Copy verbatim from the patient's chart when pos~<tle. ./;,{/ )/.<:<~'~,<l // .<::~"::':'::"''''\~~:;'',>" (( "./ ii ;.lA'?" i/ "~iti2"~JF;"";>J'\~~ :p 10. Substance(s) Involved USing available documentatIon, list a' :subs" "nees ...;:/ _.r:~"'l,te"L':\Administration l/; that caused or contnbuted to the ED VISIt ,Record SUbstances, as s~" t-ally /'/' <(, 'SV1ect One J" as possible (i.e., brand [trade) name, preferred over generic name preferreff" ~0- ~'-.''l ",/ljd :t over chemical name, etc.), Do not record the same substance by two ~~~a' J( t:/)" /~ r.l:: 0.' J;: different names. Do not record current medication.fi unrelated to the visit. ~ cOI:...:.:<:~;:,;/j)y ..z:;::11" ~> _,p ,$ c.r 0$0; toxicology tesl'Y' O"{/ -$"" -$" c.f ,:,,~,,~ Alcohol involved? 0 Yes 0 No/Not documented 0 ,~,. //" [7,;:f~ <~ ;/\. L.',:;" 'l 'I~~ ,,"". "". , /:/'~, "'", o "-"'~" /Y""! .;'.." ">" '" .'/ 77r ~\..-;;::+'"-,, ~ ~:'~11~,^" '~~~,,\~l:~f o G~::",DltTI "\:::::::~~:, Other di:)position: o Transferred o Left against medical advice D Died D Other o Not documented 3. Time of Visit 4. Age Da.m. D p.m. o military o Less than 1 year o Not documented HOUR MINUTE rnrn D 1. 2. 6. Sex o Male o Female D Not documented 7" Race/Ethnicity Select one or more: D White o Black or African American o Hispanic or latino o Asian o American Indian or Alaska Native o Native Hawaiian or Other Pacific Islander o Not documented ? ~" ..f v 15' # 2 3 4 11. Type of Case Using the Decision Tree, select the first category that applies: o Suicide attempt o Seeking detox o Alcohol only (age <21) o Adverse reaction o Overmedication o Malicious poisoning o Accidental ingestion o Other ~M^ 100-ljHV ;2/1005 12. Disposition Select one; Treated and released: Admitted to this hospital: o Discharged home 0 ICU/Critical care o Released to police/jail 0 Surgery o Referred to detox/ 0 Chemical dependency/detox treatment 0 Psychiatric unit o Other inpatient unit 13. Comments Enter here any questions or issues you have about this case. Do flot include infon-nation that could identify the patient. DAWN is operated by the Substance Abuse and Mental Health Services Administration (SAMHSA) of the U.S. Department of Health and Human Services, as required in Section 505 of the Public Health Service Act (42 V.S.C. 290aa.4). DAWN is used to monitor trends in the adverse health consequences associated with drug use. Section 501 (n) of the Public Health Service Act prohibits SAMHSA from using or disclosing DAWN data for any purpose other than that for which they were collected. Public reporting burden for DAWN emergency departments is estimated at 77 minutes per case. This includes time for reviewing ED charts and completing case report and activity report forms. Send comments regarding burden to $AMHSA Reports clearance Officer, Paperwork Reduction Project 0930-0078, 1 Choke Cherry Road, Room 7.' 044. Rockville, MD 20857. An agency may not conduct or sponsor, and a person is not required to respond to. a collection of information unless it displays a currently valid OMS control number. The OMS control num ber for this project is. 0930~0078. DAWN; 2006: NATIONAL ED ESTIMATES 79 .. S31lfV>lllS3 03 llfNOl1lfN :900Z 'NMlfO os 'papnpxa aJe (asn lua:JaJ ou pue) asn 5nJp)0 AJ01S!4 e 41!M Slua!led 'S! le41 l '(6nJp B!O alll!l 0016U!~Bl "a'!) UO!W::l!paWJapun!o a::luanbasuo::l B SB palBaJl6u!aq S! wa!IBd a41 IIll 'I!S!^ a41 01 palBlaJ IOU aJB (SUO!IB::l!paw luaJJn::l "6'a) palS!1 s6nJp AIUO a41 111 'SllnsaJ lsal A60IO::l!XOl U! S! 6nJp B !O UO!lBluawn::lop AIUO a41 III '(JaM JO ~Z pa6B) llnpB UB S! lua!lBd a41 pUB pa^IO^U! a::lUBlsqns AIUO a41 S! 1040::l1'v' IIll 'asn lua::laJ ou lnq asn 6nJp !O AJ01S!4 B SB4 lua!lBd a41 III 'I! a\B4U! IOU PiP lnq a::lUBlsqns IB::l!lna::lBWJB4duou B pawnsuo::l lUa!wd a41 III 'palBaJl 6u!aq ln041!M 03 a41 ijallUa!lBd a41 III 'asn 6nJp lUa::laJ !O a::luap!^a ou S! aJa41 III :!! l!S!^ NM'v'O B IOU S! l!S!^ 03 u'v' 'Bpal!J::l Al!llq!6!1a NM'v'O a41 01 SUO!lda::lxa palBaU!lap ApBap Ma! 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B1BP !O uo!snpul III '6u!jJodaJ 6nJp lUBpUnpaJuou pUB '::l!!pads 'ajBJn::l::l'v' III '6u!jJodaJ 6nJp IB1Uappu! !O UO!lBU!W!13 IIlI 'UO!l!sods!p lUa!lBd uo I!Blap \BUO!l!PPB pUB asn 6nJP!0 spaua 41lBa4 a41 uo Swal! B1BP!0 uo!snpul l1li 'UO!lBP!lB^ B1BP pUB SldWOJd palBWOlnB 41!M 6u!jJodaJ ::l!UOJpaI3 III 'S03 6U!lBd!::l!jJBd U! pawaJllUa!wd Ala^a JO! spJO::laJ IB::l!paW 03 !O Ma!^aJ a^!padsOJlatj flI :6U!MOIIO! a4j 6u!pnpu! 'B1Bp NM'v'O!O Al!l!qB!laJ pUB Al!lBnb a41 a^oJdw! 01 pasn aJB sp041aw IBJa^as ^l!l!qe!laJ plle ^l!Ienb elep a~ueLJlIa leLJl SaJnleal NMV'O " ~ Types of cases in DAWN By design, DAWN's broad case criteria yield a diverse set of visits. To bring order to this heterogeneous mix of ED visits, each visit is assigned to one of eight types, which may be analyzed separately or in purposeful combinations. The eight types of visits are: lID Suicide attempt, III Seeking detoxification, III Alcohol only in patients under age 21, II Adverse reaction, lID Overmedication, Ifl Malicious poisoning (including drug-facilitated sexual assault or product tampering), III Accidental ingestion, and iii Other. DAWN Reporters assign each DAWN case to one, and only one, of the eight case types, based on a series of questions and decision rules. The questions and rules are organized as a decision tree (Figure C2). Starting at the top, each case is assigned to the first case type that applies, even if the case might also meet the rules for a subsequent category. The eight case types were ordered with this in mind. The final category in the decision tree is called Other and it is reserved for DAWN visits that do not meet any of the rules for classification into one of the first seven types. By design, most cases of drug abuse are classified as case type Other. This approach, which never directly identifies drug abuse, comes from the recognition that medical records frequently lack explicit documentation of substance abuse. This lack of documentation may occur for several reasons. First, the distinctions among use, misuse, and abuse are often subjective. Second, if there is a low index of suspicion for drug abuse in some types of patients, ED physicians may be unlikely to label those types of patients as drug abusers. Third, in many States, insurers may legally deny payment for ED visits related to substance abuse. Thus, financial incentives may be a powerful factor to influence documentation practices. Drugs included in DAWN DAWN includes all types of drugs:3 II Illegal drugs, such as heroin, cocaine, marijuana, and Ecstasy, III Prescription drugs, such as Prozac@, Vicodin@, OxyContin@, alprazolam, and methylphenidate, iii Over-the-counter (OTC) medications, including aspirin, acetaminophen, ibuprofen, and multi-ingredient cough and cold remedies, II Dietary supplements, including vitamins, herbal remedies, and nutritional products, II Psychoactive, non pharmaceutical inhalants, l1li Alcohol in combination with other drugs, and III Alcohol alone, in patients aged less than 21 years. 3 The classification of drugs used in DAWN is derived from the Multum Lexicon, @2007, Multum Information Services, Inc. The classification was modified to meet DAWN's unique requirements (2007). The Multum Licensing Agreement governing use of the Lexicon is provided in Appendix A and can be found on the Internet at httpllwww.multum.com. 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I' Dsap " U~'1f11 peq A,rJ,t/J ,ofJJO:J'" j"4-' S3A , 080p ptJSsJw B dn D~etu OJ pa~Jl" j L....."......::OI1.V~~~~~..:.~i 6nJp JO ..POJJ~ ~/S~ .. suo!~a8JoJul tJma .. SUO/J3UO) :J/6J911tt .. NOl1.01131J 3SIJ31WV /'0 [---- --..---\ 6nJp Aiuo BIn $1I0qO'lepu'lz.6OJapunjUOI,edo ~- S3A- (Ii::> 3DV) A1NO 10HO:J1V c) . ~"-~- ~-~-- ...-- lJO!IBll/!qltlliIJ 6nJp JOJ H1iiNlbel:J}_ UO!$$/wpe JVO~UleOJl 6mp.JO:J Ir.JUf!J,ffOp je'3jpOi'" SaA uor:fl~IJfJ(oUJP 6Uf.'1"C1S" X0130 !IN/J/33S ,,0 [ JIOflm" O.l P~dWO~U~" DP/:J!ns POJoJdwo:J .. ..~dwQUIl apF)lns.. .. - S3.A l.dW3LLtl30/:JJnS to ~~.,,"-_._,""""- ()N~ lJuawo.lddns hJ6l0lP J'O UO!tn:ll'POW J9lunOO'-94l-J9hO un JO D'80p 'POPU3'WWO:)OJ a~l 10 5n.p UOlldllOsaJd a 10 asop paQlloOaJd 041 paaoxa Iualled a41 Pia '9 UOUt/.'31pt1W m (Jrop 9,8S16 au08W.o$' >fOOl" Map ptJq!J':.'J69Jd ;/Jf:tl/~ 6sa, 'toO" ~UOUf10fP9li1 OJUlI oo.{.. .. tlO,,3ei3..1 .(J$J'l).Jl.PU" 10 uotJf11uown:>op m04W~ i"3/~Ol" slimp 1l'3JW 01 UOI1:N1OJpcn:><<$xoun .. ON LpapuawwooaJ JO ,paqlJOswd se ua~all"awOlddns AI1l10lp JO 'U.OIIIt:l!pOW JOjunoO'''41.JOAO '6nJp UO!ldIJ~swd a 01 .,uolloao. oSJa^pe" ue P04 Iuolled a4\le4\ alaOlpUIlJe40 041S000 '1' Jl:JilO JO l & ofJrl SIIUOIJOd .. ON pOI\I(MU! (JJ11/0L/O:JlfI pUB (tf}BnJp .J9ql(J '" 1.1.040041 U! pouo!luew 5nJp AluO 041 sIIO~ool. pUO ~~ 950 lepun IUellOd 941 sl 'C XOl;}P 6Uf'lOUS IOU mq ~1r1MeJp(mM" ON l.WBJ60Jd JuawteaJl 6nJp U OlUJ AJ~ua JO XOl9p 6UP1aas 8eM :luenBd 94118\11 a;OOIPU! ~JBLI:O all1- SGOO 'Z JJ."$ WJUlI OJ p;lJ.Il '" uOllrm/BAQ 4:M.Sd .. ld~B BPI:)!"'" 10 UOnUlu.a.wn:>op ON.. ON ~ UOJJlt9Pl apPI1tS" .. I.paAIOAU! 5n.p 0 ~I!M aplolns p9ldwo"e IUOIIOd 0411a41 910~lpU! pe40 a41 SOOO '~ SilAlfi.l!J OJ ,J1'e:) to m:1A.l u5[s'SV 'lliP16 U! 'EiuO!tsanb 6u!MOlIOJ Olfi Ja^,\suV 'aseo NM110 e oj SI41 S3A I <.asn 6nJp 01 pallllaJ JO Aq pa::mpU! UO!llpUOO II JOIl!S!^03 a4l SliM 'lJ1l40 a41 U! uO!lllwawnoop UO pases ,ase::> NMVO e S!4l 51 aaJl UO!S!Oaa NM\fO aaJl UO!Spap ase:> lO adAl Z~ aJn6!:1 If To be reportable, a nonpharmaceutical substance must be consumed by inhalation, sniffing, or snorting, and it must have a psychoactive effect when inhaled. An ED visit involving inhalation of a non pharmaceutical, psychoactive substance and no other drug qualifies as a DAWN case. Carbon monoxide is excluded from the inhalants. Beginning in 2004, cases involving accidental exposures (e.g., exposure to paint fumes while one is painting a closet) are excluded as well. Hospital participation For 2006, 205 hospitals submitted data on 269,339 drug-related ED visits that were used for estimation (Tables C1 and C2). The overall weighted response rate was 26.1 %. For the 12 oversampled metropolitan areas and divisions, individual response rates ranged from 30.8% in the Houston-Bay town-Sugar Land, TX Metropolitan Statistical Area to 71.2% in the Detroit-Warren-Livonia, MI Metropolitan Statistical Area. For 2005, 224 hospitals submitted data on 268,128 drug-related ED visits that were used for estimation. The overall weighted response rate in 2005 was 28.9%. There were 13 oversampled areas in 2005 with response rates ranging from 31.1 % to 77.3%. For 2004, 220 hospitals submitted data on 168,841 drug-related ED visits that were used for estimation. The overall weighted response rate in 2004 was 23.9%. There were 13 oversampled areas in 2004 with response rates ranging from 35.3% to 70.8%. Charts reviewed for drug-related ED visits DAWN cases are found through a retrospective review of medical records in participating hospitals. Across all participating hospitals in 2006, 9,837,481 charts were reviewed to find the drug-related ED visits that met the DAWN case criteria. Based on the review of charts, 346,946 drug-related visits4 were found and submitted to the DAWN database, a case rate of 3.5%. On average, a DAWN member hospital submitted 1,077 DAWN cases. However, the number of submitted cases varied widely across hospitals, from 7 cases to 6,782 cases (median 820) in a single hospital during 2006. Across all participating hospitals in 2005, 11,472,887 charts were reviewed to find the drug-related ED visits that met the DAWN case criteria. Based on the review of charts, 374,276 drug-related visits were found and submitted, a case rate of 3.3%. On average, a DAWN member hospital submitted 843 DAWN cases. The number of DAWN cases varied widely, from 1 case to 9,021 (median 525) for a single hospital. Across all participating hospitals in 2004, 13,299,739 charts were reviewed to find the drug-related ED visits that met the DAWN case criteria. Based on the review of charts, 307,094 drug-related visits were found and submitted, a case rate of 2.3%. On average, a DAWN member hospital submitted 609 DAWN cases. The number of DAWN cases varied widely, from 1 case to 7,485 (median 377) for a single hospital. 4 For 2004-2006, more hospitals participated in DAWN than were used in estimation. Therefore, the number of drug-related ED visits from all participating hospitals exceeded the number used for estimation. DAWN, 2006: NATIONAL ED ESTIMATES 83 ~ S31'v'~IlS3 03 l'v'NOIl'v'N :900<; 'NM'v'O 1>9 'AI!J ~JOA MaN )0 S46nOJOS aA!) a41 6u!spdwo~ eaJeqns a41 01 pal!w!I S! a6eJaAO:J :J!4deJ60a6 '~JOA MaN JO) :uo!lda:Jxa auo 41!M '(IWlnO-SOq/SUl)allnq/qwoIA~6'asn04al!4MMMM/;:dll41e alqel!eAe) som: aunr U! la6pns pue luawa6euelN)0 a:J!JJO a41 Aq panSS! suol)!u!)ap pJepuelS a41 MOllO) SUO!S!A!O uelllOdoJlalN pue (S'v'SlN) seaJ'v' 1f:l:J!IS!If:llS Uf:ll!lodOJlalN S WIOl a41 01 wns 10U op UM04s sjUauodwo~ 'aJo)aJa41 's'n a41)0 Japu!f:lwaJ a41 pue UM04s seaJe Uel!IOdoJlaW WOJ) SIellds04 alq!6!1a apnpu! 's'n a41 U! Slel!ds04 alq!6!1a 1f:lIOl 'NM'v'O JOJ alq!6!1a aJe 'Aall.Jns If:lnuu'v' (IIHII) uO!leposs'v' lel!dsOH ue:Jpaw'v' a41 uo pasf:lq 'sjUawjJedap A~ua6Jawa Jn04-v1: 41!M SIf:lI!ds04 leJapa:l-uou 'If:lJaua6 'WJal-jJ04S 'v'SlN 'v''J 'IUOWaJ:l-pUf:lI~eo-o:JspUf:lJ:l G'V9 Hv Hv 8 8~ 8~ Uf:lS JO UO!S!A!O Uf:lI!lodoJlalN 'v''J 'Al!'J pooMpatj-oalf:llN Uf:lS-o:JspUf:lJ:l Uf:lS 'v'SlN 'v'd-rN-AN 'UOS!P3-~Jf:lMaN 0'99 ~'9v 8'89 ~G 68 09 -~JO A MaN JO Sa!luno'J PUOW4:J!tj 'suaano '~JOA MaN 's5U1)j 'XUOJg 'v'SlN l:l '4~f:lag !Wf:l!lN-alf:lpJapnf:ll ~'09 L'9v 0'09 8 9~ GG jJo:l-!Wf:lilN JO UO!S!A!O uf:ll!lodoJlalN l:l 'lIf:lpua)j-4:Jf:lag !Wf:l!lN-!Wf:l!lN G99 9'9v 9'9v O~ GG VG 'v'SlN 'v'M 'anAallag-f:lWo:Jf:l1-alneas L99 0'09 0'09 8 9~ 9~ 'v'SlN 'v''J 'so:JJf:llN ues-pf:lqslJf:l'J-05a!O ues ~'89 8'89 8'89 v~ 9G 8G 'v'SlN Z'v' 'alf:lpSnO:Js-f:lsalN-X!Ua04d O'VV O'L8 O'L8 O~ LG LG 'v'SlN IM-NlN 'UOI5u!wOolg-lnf:ld 'IS-s!lodf:lauu!lN 8'OS 8'81: 9'81: Gf GV Lv \lSlN Xl 'PUf:ll Jf:l6nS-UMOIAf:lg-uolsnoH nL L'69 L'99 9~ VG L8 'v'SlN IlN 'f:l!uoA!l-UaJJf:lM-I!OJlao ~'89 0'09 0'09 6 9~ 9~ 'v'SlN O'J 'eJoJn'v'- JaAUao G'98 L'L8 998 LG vL 06 'v'SlN IM-NI-11 'la!lOr-all!lI.Jadf:lN-05f:l:J!4'J t'L9 9'89 9'89 H 6G OV 'v'SlN HN-'v'lN 'A:Ju!no-a6ppqwf:l'J-UOls09 SSf:laJf:lqns PUf:l SUO!S!A!O uf:ll!lodoJlalN r9G 6'vG L'L8 90l vv9 899'v l's'n If:ll01 alf:lJ alf:lJ SIf:ll!ds04 asuodsaJ asuodsaJ paldwf:ls aldwf:ls U! aldwf:ls U! ~ SIf:ll!ds04 pal4fl!aM 14fl!aM J oJ alf:lJ SIf:ll!dS04 SIf:ll!dS04 alq!fl!la eaJe O!4deJ50a~ SI!S!^ ufl!saa asuodsatj flu!puodsatj I alq!fl!l3 If:ll01 luaOJad I s(S'v'SV\J) seaJ'v' If:lo!ls!lelS Uel!IOdoJlalN 900Z Jea~ UO!lOaIlOO BlBO ~:) 91qel d Table C2 Drug-related ED visits, by type of case: 2006 Unweighted Weighted Relative 95% Confidence interval standard sample data estimates 1 error (RSE) Lower bound Upper bou nd Suicide attempt 11,840 182,805 8.0 154,185 - 211,424 Seeking detox 18,789 118,355 12,1 90,171 - 146,540 Alcohol only (age < 21) 9,940 125,888 12,5 95,087 - 156,690 Adverse reaction 93,507 1,526,010 9,3 1,247,859 - 1,804,161 Overmedication 20,643 285,828 6,2 250,991 - 320,664 Malicious poisoning 750 8,817 13.1 6,546 - 11,088 Accidental ingestion 4,117 79,011 9,1 64,855 - 93,166 Other 109,753 1,115,141 13,0 832,069 - 1,398,213 Total drug-related ED visits 269,339 3,441,855 6.1 3,033,110 - 3,850,600 Total drug misuse/abuse visits 164,334 1,742,887 8.5 1,451,086 - 2,034,688 Total ED visits (all reasons) 8,930,694 113,110,132 0.0 - Drug-related ED visits Suicide attempt 25,096 402,907 9,1 331,056 - 474,758 Seeking detox 38,909 243,297 13.3 180,091 - 306,502 Alcohol only (age < 21) 9,940 125,888 12.5 95,087 - 156,690 Adverse reaction 120,016 2,055,783 11.1 1,608,379 - 2,503,188 Overmedication 35,340 506,476 6.6 441,034 - 571,919 Malicious poisoning 1,295 15,293 12.7 11,482 - 19,105 Accidental ingestion 5,200 98,613 9.1 81,048 - 116,178 Other 183,642 1,936,561 10.7 1,531,598 - 2,341,524 Drugs in all drug-related ED 419,438 5,384,819 6.3 4,716,771 - 6,052,867 visits Drugs in all misuse/abuse ED 282,938 3,086,984 7.2 2,649,699 - 3,524,268 visits Drugs2 1 These are estimates based on a representative sample of non-Federal, short-stay hospitals with 24-hour EDs in the United States. 2 These are estimates of drugs. A single ED visit may involve multiple drugs. SOURCE: Office of Applied Studies, SAMHSA, Drug Abuse Warning Network, 2006 (03/2008 update). DAWN, 2006: NATIONAL ED ESTIMATES 85 .. S31VVlIlS3 03 lVNOllVN :900<: 'NMVO 98 'sase:> UO!ISa5uI leluapp:>e JO uOIpeaJ aSJaApe apnpu! JaAaU Pln04s '45n041 'asn le:>!pawuoN 'asn le:>lpawuou se paJap!suo:> aq 145!W Aa41 sasodJnd Ja410 JO) Inq 'AlaleJedas pazAleue aJe XOlap 5u!~aas pue Idwane apP!ns)o sadAI ase:> a41 UO!le:>!lqnd S!41 UI :31ON (asnqe BnJp paluawn:>op sapnl:JuI :adAI ase:J Ja410ue 01 pauBIsse aq IOU Plno:J le41 sase:J) Ja410 adAI aseJ - (asodJnd snop!lew e JO) Ja410ue Aq BnJp e paJaIS!u!wpe seM lua!led a41 4:J!4M uI sase:J) Bu!uos!od sno!:J!leV'J - (asnqe BnJp )0 uO!leluawn:Jop 1!:J!ldxa BU!~:Jel sluawalddns AJela!o - asns!w 'aSnJaAO 'asn le:J!pawuou)o sase:J) UO!le:JlpawJaAO - sle:J!lna:JeWJe4d sle:J!lna:JeWJe4d sad"l ase:J aaJ41)0 uO!leUlqwoJ JlO pue uO!ldp:JsaJd - )0 asn le:JlpawuoN (~Z > aBe) "IUO 1040:J11i - XOlap Bu!~aa8 - sldwalle apP!n8 - ~Z )0 aBe ~Z aBe Japun slua1led JO) sad"l ase:J a41 Japun Slua!led uI "luO 1040:J11i - BUIMOIIO) a41 UI "IUO Jeadde BnJp alos a41 se 1040:Jle 41!M saseJ (s)BnJp aBe )0 SSalPJ8BaJ 'sad"l aS8:> IIIi Ja410 41!M UO!18ulqwo:J U! 1040:J11i - 1040:J18 )0 asn sBnJp IP!lI! )0 suol18UlqwOJ - s1u8184u! 18:J!lna:J8WJ84duON - suaBoupnll84 Ja410 - dJd - 081 - aUlw8la>t - (loudA40tj) w8daz8JI!unl.:l - 8H8 - liV'JOV'J - ( aU!w8la4dw84law PU8 saulw8la4dw8) s1U81nw!18 - 8U8nf1J8V'J - u!oJaH - sad"l aS8:J IIIi aU!8:JoJ - sBnJp IP!II! )0 asn papnl:>u! sad~ ase:::> papnpu! s6nJQ luawaAIOAU! 6nJp 10 adAl NMVO u! esnqe pue esnS!w 6nJp O~ pe~eleJ S~!S!^ 03 f:J elqel '900i: pue '900i: 'VOOi: U! 'a6ela^e uo 's6nlp 9' ~ pa^lo^u! l!S!^ 03 palE?lal-6nJp 'rJ 'a^!snpxa ^lIenlnw IOU ale sap06ale:J asa4l 'l!S!^ al6u!s E? U! pa^IO^U! aq Aew s6nlp ald!llnw asnE?:Jag 'tJ alqel U! UM04s se adAl ase:J pue 6nlp Aq paU!lap ale sap06ale:J aa14l asa41 '(s6nlp Jl0 10 UO!ldp:>sald "6'a) sle:J!lna:JeW1E?4d lO asn le:J!pawuoN III pue '~i: lO a6e a411apun SIUa!led UI auolE? 1040:Jle pue 's6nlp la4lo 41!M UO!leu!qwo:J U! '1040:Jle lO asn III 's6nlp lP!lI! lO asn E! :UO paseq ale '4lleaH pue asn 6nlO uo AaAlns leuO!leN a4llo 4:Jeoldde a4llalleled Ol pau6!sap 'sap06ale:J asa41 'pau!lap alaM asnqe pue asns!w 6nlp Ol palelal Sl!S!^ O3lo sap06ale:J aa14l 'S!SAleUe 10;1 uone::>!Iqnd S!l/l U! ewp NM'\10 .. Sampling and estimation DAWN sample design The redesign of the DAWN system introduced in 2003 altered most of the major features of the DAWN data collection and included a new sample of hospitals that constituted the DAWN. The new sampling plan, fully implemented for the first time for the 2004 estimates, formed a nationally representative panel of hospitals to be followed longitudinally for the indefinite future. Briefly, this new design is a probability-based, stratified, one-stage sample. A complete and accurate list of all hospitals in the United States was drawn and, from that, all hospitals meeting the criteria for the target sample frame were identified. Samples were drawn to provide the capability to make estimates for the Nation as well as select Metropolitan Statistical Areas (MSAs) and divisions (Table C4). Each year the sample frame is updated to account for new hospitals. The stratified design called for drawing oversamples of hospitals in 48 MSAs; in four of those 48 MSAs, additional oversamples were drawn for a total of nine divisions.5 In effect, there are 53 nonoverlapping geographic areas (44 whole MSAs and nine divisions). (See Table C4 for list of MSAs and divisions6 where oversamples were drawn.) These areas are collectively referred to as oversample areas, or OS areas. Metropolitan Statistical Areas and subdivisions In order to accommodate a planned expansion of the metropolitan areas covered by DAWN, a maximum set of metropolitan areas, based on the definitions issued by the Office of Management and Budget (OMB) in June 2003, was selected. Which metropolitan areas to include was a topic of the DAWN redesign.? Retention of the existing 21 metropolitan areas was important because there was significant demand for estimates for those areas, and addition of the five most populous metropolitan areas in each of the nine Census divisions was deemed important to improve DAWN's geographic and population coverage. This yielded a total of 48 metropolitan areas. For many of the 48 metropolitan areas, the June 2003 definitions resulted in larger metropolitan areas. In some cases, these larger areas represented a merger of previously separate metropolitan areas. However, there continued to be strong interest among users of DAWN statistics in the areas covered by the original 21 metropolitan areas. In order to address the needs of these users, four of the merged areas were subdivided.8 For each of these areas, there was a sample for the metropolitan area, as well as a sample for each subdivision. This would enable DAWN to produce estimates for the metropolitan areas and for the subdivisions. As a result of this process, the final metropolitan-area sample included a total of 53 geographic units: 48 metropolitan areas, 2 subdivisions each for 3 of these metropolitan areas, and 3 subdivisions for one of these metropolitan areas. 5 The four MSAs where samples were drawn for divisions are Los Angeles, Miami, New York, and San Francisco. The division definitions used by DAWN follow Census Bureau definitions of Metropolitan Divisions, except in New York where the three submetropolitan areas were defined uniquely based on local input. 6 MSAs and Metropolitan Divisions follow the standard definitions issued by the Office of Management and Budget in June 2003 (avail able at http://www.whitehouse.gov/omb/bulletins/b03-04.html and http://www.census.gov/populalion/www lestimates/metrodef htm I). 7 Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Drug Abuse Warning Network: Development of a New Design (Methodology Report). DAWN Series M-4, DHHS Publication No. (SMA) 02-3754, Rockville, MD, 2002. 8 When metropolitan areas were redefined in June 2003 based on data from the 2000 decennial Census, several legacy MSAs were merged with other MSAs to form new, much larger MSAs. However, a strong constituency of DAWN data users still needed estimates for the pre-merger areas. Because of this, four of the 48 metropolitan areas-Los Angeles, Miami, New York, and San Francisco- were subdivided into a total of nine divisions, corresponding to the constituents' areas of interest. DAWN, 2006: NATIONAL ED ESTIMATES 87 .q S311lv.lIIS3 03 lllNOlllIN :90OZ 'NMIIO 99 'eaJII le:>ljs!jejS uej!lodoJjal^J lid -rN- AN 'UOS!P3-~JeMaN-~JO A MaN a4j uI pau!ejuo:> aJe (~JeMaN pue ~JO A MaN) seaJe A:>e5al ajeJedas OMI 'eaJe A:>e5al e sajouao S>i 'ej!4:>!M .AM-O l^J-'if A -80 'eppUeXal'if-uoj5uIIJ'if-uojBUl4SeM Z'if 'uoson 1 lj 'JajeMJeaIJ-BJnqsJajad 'js-edwel .11-0l^J 'slnol 'jS . 'ifM 'anAallas-ewooe l-ameas (UOISIAIO uel!lodoJjal^J 'if8 'Aj18 pooMpaCj-Oajel^J ues-oospueJj ues sUlejuoo) uOIsIAlp oospueJj ueS - 'if8 'juowaJj-pUel~eO-OOspueJj ueS (UOISIA10 Uej!lodoJjal^J 'if8 'pJeMAeH-jUOWaJj-pUel~eo SUlejUoo) UO!S!AIP puel~eo - 'if8 'juowaJj-pUel~eo-oOsloueJj ueS . 'if 8 'juowaJj-pUel~eO-OOs!oueJj ues . 'if8 'sooJelf\J ues-peqspeJ-oBa!o ueS Xl 'OIUOjU'if ueS In 'AjIJ a~eljles 'if8 'aIlIAasoCj-apeoJ'if-uapJ'if-ojuaweJoes AN 'JajSa400Cj 'if8 'opejUO-OUIPJeUJas ues-ap!sJaAICj 'iflf\J-ICj 'JaAICj Ilej-pJoJPaS MaN-aOuap!AOJd 'ifM-CjO 'uojJaAeaS-JaAnOOUeA-pueljJod 'ifd '4BJnqsn!d .Z'if 'alepSnOOs-esalf\J-x!ua04d .0 If\J-3 O-rN-'if d 'uojBUIW I !M-UapweJ-e! 4d lapel! 4d 'if1-3N 'sUnlS IpunoJ-e4ewo (AN 'SaljUn08 PUOW40!Cj 'suaano '~JOA MaN 's5UI>i 'XUOJS Su!ejUoo) UO!S!A!P S45noJos 9' 'Aj!J ~JOA MaN - 'ifd-fN-AN 'UOSIP3-~JeMaN-~JOA MaN (AN 'sa!junoJ Jajsa40jsaM '~Iouns 'puel~ooCj 'WeUjnd 'nesseN su!ejuo:>) UO!SIA!P ueqJnqns ~JOA MaN - 'ifd-fN-AN 'UOS!P3-~JeMaN-~JOA MaN ('ifd 'Ajun08 a~ld pue 'rN 'sa!junoJ :>Iessed 'uospnH 'uaBJas 'UO!Un 'xassns 'SpJOlf\J 'uopJajUnH 'xass3 'jasJaWOS 'ueaoo '4jnOwUOlf\J 'xaSaIPp!l^J Su!ejUo:>) UO!S!AIP AasJaf MaN - 'ifd-rN-AN 'UOS!P3-~JeMaN-~JOA MaN . 'ifd-rN- AN 'UOS!P3-~JeMaN-~JOA MaN . 'ifl 'JaUUa>i-aplejalf\J-Sueapo MaN lJ 'pJojl!lf\J-UaAeH MaN Nl 'OJoqsaaJjJnlf\J-UOSP!Aeo-all!A4SeN .IM-Nlf\J 'UOjBUIWOOIS-lned 'js-s!lodeauu!l^J (UOISIAIO uel!lodoJlalf\J lj 'llepUa>i-40eas !wellf\J-lwe!lf\J SUlejUOO) UO!SIAIP Alun08 apeO-Iwe!lf\J -lj '40eas !we!lf\J-alepJapnel jJOj-!wellf\J (SUO!SIA!O Uel!IOdoJjalf\J 'lj '4:>eas UOIUAoS-UOleCj eooS-4:>eas wled jsaM pue 'lj '40eas Pla!jJaaO-40eas ouedwOd -alepJapnel jJOj SUlejUoo) UOIS!AIP alepJapnel jJOj -lj '40eas Iwe!lf\J-alepJapneljJOj-!well^J .lj '40eas !we!lf\J-alepJapnel jJOj-!we!l^J Cj'if-Slf\J-Nl 'S!4dwalf\J NI-A>i 'all!AS!nOl AN 'as!peJed-seBaA sel (UO!S!AIO uel!lodoJlalf\J 'if8 'aU!AJI-Wla4eU'if-eU'if ejues su!ejuoo) UOIS!A!P AjUn08 aBueJO - 'if8 'eu'if elueS-40eas Buol-SaiaBu'if sOl (UO!SIA!O uel!lodoJlalf\J 'ifJ 'alepuaI8-40eas Buol-SaiaBu'if sOl su!ejuoo) UO!S!A!P SalaBu'if sOl - 'ifJ 'eu'if ejueS-40eas Buol-SalaBu'if sOl . 'if8 'eu'if ejueS-40eas Buol-SalaBu'if sOl S>i-Olf\J 'AI!8 sesue>i NI 's!lodeUeIPul Xl 'puel JeBnS-UMOjAeS-UOjSnOH IH 'nlnlouoH lJ 'pJo)lJeH jse3-pJojjJeH jsaM-pJojjJeH .1lf\J 'e!uoA!l-uaJJeM-jIOJjaO .OJ 'eJoJn'if-JaAUao .Xl 'uojBu!lJ'if-4jJOM jJoj-selleo HO 'snqwnl08 HO 'Jojualf\J-epAI3-puelaAaIJ NI- A>i-HO 'uMolaIPp!lf\J-lleuupuIJ .IM-NI-11 'ja!lOr-aIlIAJadeN-05eo!4J .AN 'epueMeuol-eBeMOj~aa48-0Ieuns lJ '~leMJON-pJOjWejS-jJodaBpPS .HN-'iflf\J 'Aou!no-aBppqwe8-UOjSOS l'if 'JaAOOH-We4Bu!WJ!S .0lf\J 'uosMol-aJOWllles Xl '~ooCj punoCj-u!jsn'if . 'if8 'enapelf\J-sBupdS Apues-ejUell\f UD!Sep eldwes NMVO U! seeJe (SO) eldwesJeAO v8 elqel <> Sampled hospitals in each of the OS areas were stratified by hospital size (up to four categories based on volume of ED visits) and ownership type (public and private). (Size categories were determined independently for each OS area.) The stratification plan included an additional geographic construct for the remainder of the United States outside the OS areas. Hospitals in the remainder area were stratified into 24 remainder strata based on four regions (Northeast, South, Midwest, West), hospital size (three size categories based on volume of ED visits), and ownership type (public and private). To begin, a cross classification was created by categories of ownership type and geographic unit. Within each combination of geographic area and ownership type, the number of hospitals determined the number of unique size categories. If there were three or fewer hospitals, only one size category was defined. If there were four, five, six, or seven hospitals, two size categories were defined. If there were eight or more hospitals, four size categories were defined. In the remainder sample, within each combination of Census region and ownership, there were three size categories. This produced 24 unique strata from which to draw the hospitals for the remainder sample.9 The DAWN national estimates are the sum of the estimates for OS areas and the remainder area. Using a formula, the national estimate is depicted as: ( ~ajJ+b where ai is the estimate for OS area i, 53 is the number of OS areas, and b is the remainder area estimate. It was never expected that DAWN would be able to expand data collection into all 53 OS areas. Instead, the expectation was that DAWN would build up gradually to the number of OS areas its budget could support. The DAWN sample design was conceived to provide the flexibility to change gradually over time in terms of the number of OS areas where data were collected, while providing the statistical infrastructure to enable the production of reliable and representative estimates for the Nation and select OS areas, regardless of their number. To accomplish this, the DAWN design incorporates an approach whereby a subset of the hospitals within the OS areas was identified a priori as having a dual-purpose in estimation. Referred to as "dual-purpose hospitals," these designated hospitals can contribute to an estimate for the OS area in which they are located or they can contribute to the estimate for the remainder area. Dual-purpose hospitals carry two probabilities of selection (PaS) and two stratum identifiers. One PaS/stratum is associated with membership in an OS-area sample and the other is associated with membership in the remainder-area sample.10 9 Four Census regions times two ownership categories times three size categories equals 24 strata. 10 In addition, a portion of hospitals in the nine oversampled divisions were identified a priori to serve in their MSA-Ievel oversample and were assigned an OS area level POS/stratum for that third purpose. Therefore, hospitals in the four MSAs with division-level oversampling can have up to three nonzero POS/strata: (1) a POS/stratum for membership in the MSA; (2) a POS/stratum for membership in the division; and (3) a POS/stratum for membership in the remainder area. DAWN, 2006: NATIONAL ED ESTIMATES 89 ~ S31'v'Vol11S3 03 l'v'NOIl'v'N :90Ol 'NM'v'O 06 'WnleJls/SOd eaJe-so J!a4l 6u!sn alew!lSa eaJe-so a4l Ol alnqplUO::> Aa4l pue 'SeaJe SO a4l U! "Slel!ds04 aldwesJaAO" aq Ol paJap!Suo::> aJe 'aldwesqns asodmd-Ienp a4l U! 6u!aq se paleu6!sap Alleu!6po aS04l6u!pnpU! 'SeaJe SO auole-pUelS U! Slel!ds04 IIIi ,:seaJe SO auole-puels" se Ol paJJa!aJ aJe asa41 'Salew!lsa aleJedas JO! S!Seq a4l se UMO J!a4l uo puelS Ol paMolle aJe Al!Ienb elep alqelda::>::>e 4l!M SeaJe SO as041 'Al!Ienb elep aU!WJalap Ol paMa!AaJ aJe eaJe SO 4::>ea JO! sUJaned asuodsaJuou pue SaleJ asuodsaJ a4l 'S!4l op 01 "SaleW!lSa s.JeaA le4l U! Aeld II!M lel!ds04 paldwes 4::>ea aloJ 4::>!4M aU!WJalap Ol S! dals lSJ!! a4l 'JeaA elep 4::>ea JO! uO!lew!lsa JO::l J:f J:f J:f ~~ .. J:fJ:f J:f ~ .. .. J:f J:f J:f .. .. J:f J:fJ:f ~~ .. .. J:f J:f J:f ~ .. J:f J:f J:f i~ ~9 .. .. J:f J:fJ:f .. J:fJ:fJ:fJ:f ~ .. .. J:f J:f J:f J:f ~ .. J:f J:f J:f !, 19- 19-, .. .. " , " , , \. )~l ) V Slel!dsOH aldwesJaAO y Slel!dsOH Slel!dsOH esodJnd : aldwes Japu!ewaCl -lena : \. V seaJV aldwesJaAO ) UD!sep eldwes NM'v'O leU!DPO ~8 eJn5!.::l "AJlUno::> a4l !O lsaJ a4lluasaJdaJ Ol aldwes Japu!ewaJ e III pue 'seaJe as04l U!4l!M Slel!ds04 asodJnd-lenp iii 'seaJe SO !O sap as e WOJ! saldwes lenp!A!pU! I1Il :ap!AoJd Ol UMeJp seM l! se aldwes le!l!U! a4l sp!dap 88 am6!::! <> ... If it is determined based on response rates and bias analyses that an OS area cannot stand alone, the design provides that the OS area is eliminated as a separate area but becomes part of the remainder area. In this instance: II only those dual-purpose hospitals that are designated a priori to contribute to the remainder-area estimate are retained in the remainder-area subset, III these hospitals contribute to the remainder-area estimate using their remainder-area PaS/stratum, and l1li data from any other hospitals in the OS area are excluded from the national estimates. Figure C4 depicts the assignment of dual-purpose hospitals to either an OS area or the remainder area and the exclusion of OS hospitals outside of stand-alone OS areas that are not designated as dual purpose. Figure C4 DAWN design in practice Oversample Areas ^ r l * * i::Ii::I i::I i::I i::I * i::I i::I i::I i::I i::I * i::I i::Ii::Ii::Ii::I * * i::Ii::I i::I * * Ui::Ii::I i::I i::I' i::I * i::I i::Ii::I i::I * * ** * * * * * * ** Stand-alone Oversample Areas i::I Oversample hospital * Remainder-sample hospital D Areas in stand-alone oversample estimates D Areas in remainder estimate DAWN, 2006: NATIONAL ED ESTIMATES 91 ~ ~ S31l/VolI1S3 03 1l/NOIll/N :900<: 'NMI/O Z6 'vOOl 'OVIJ 'all!^~:JOCJ 'lL6S-vO (I/VlJS) 'oN UO!jll:J!lqnd SHHO '9l-0 salJas NMI/O 'Sj!S!1I juewjJedeo A:Jue6JeW3 peje/etf-6nJO JO sejew!ls3/eUO!leN w!Jeju/ TOOl >tJoMjeN 6U!UJllM esnqlf 6nJO 'se!pnjS pa!lddl/ jO a:J!JJO 'UO!jllJjS!U!WPI/ sa:J!Nas 4jlllaH IlljUaVIJ pUll asnql/ a:Julljsqns :U! lljllO NMI/O jO ^j!lllno a4j a^oJdWI OJ sa6ull48 :sajON Ill:J!u4:Jal '8 x!puaddl/ aas ~~ ~~'UO!le::>!Iqnd NMVO Ja!l1ea ue U! pap!^oJd S! se!q a::>npaJ pue ^l!lenb elep NM\fO aoue4ua 01 pasn Sa!50IOp041aW ^a~nS a41 uo I!elap leuO!l!pp\f 'ssa::>oJd UO!paIlO::> elep a41 U! SIU!Od leJa^as Ie SMa!MJ ^1!lenb olpafqns aJe elep a41 pue :pasn aJe Nlua elep JOJ sp041aw palewolne :5u!u!eJl a^!SualU! pue paz!lepads 41!M pap!MJd aJe NM\fO JOJ elep pallo::> 04M slenp!^!pu! a41 'se!q luawaJnseaw az!w!u!W 01 'UO!lelndod la5Jel a41 JO a5eJa^0::> %00 ~ ^lIenlJ!^ se4 aweJJ 5u!ldwes a41 asneoaq 'paz!w!u!W S! se!q a5eJa^0:) 'aweJJ 5u!ldwes lel!ds04 lemU! a41pnJlSuo::> 01 pasn aJe epalP::> pau!Jap ^l1eap 'aldwexa JO.:l 'se!q 5upnpOJlU! JOJ le!IUalOd a41 a::>npaJ le41 SIO::>OlOJd pue 'sa::>!peJd 'sanb!U4::>al ua^oJd sapnpu! ^50IOp041aw ^a~ns NM\fO a41 'sanle^ UO!lelndod 5u!puodsaJJo::> lnoqe a5palMou~ aleJno::>e saJ!nbaJ I! asne::>aq lln::>!H!p S! se!q 5upnseaV'J 'JOJJa lIeJaM 01 alnqplUo::> oSle le41 ,:se!q" se 01 paJJaJaJ uayo 'JOJJa JO sa::>Jnos leuO!I!ppe aJe aJa41 'JOJJa az!w!u!W 01 pau5!sap aJe a^oqe paqp::>sap Sa!50IOp041aw le::>!ls!lelS a41 'ISaJaju! JO uO!lelndod a41 JO as041 WOJJ JaWP aldwes ^a~ns a41 WOJJ s5u!pu!J 4::>!4M Ollualxa a41 S! 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NM VO asne:Ja8 a~UeUalU!ew aldwes 'seaJe SO a41 U!41!M ^l!Ienb elep pue SaleJ asuodsaJ a41 uo 5u!puadap Jea^ 01 Jea^ WOJJ sa5ue4::> aldwes Japu!ewaJ a41 U! d!4SJaqwaw lel!ds04 :p!nIJ aq OJ pau5!sap S! Slel!ds04 JO aldwes Japu!ewaJ a41 pue eaJe Japu!ewaJ a41 JO UO!j!u!Jap a411e41 alOu OlluelJodw! S! II 'auole puelS IOU aJe le41 seaJe SO U! Slel!ds04 asodJnd-lenp JO a^!snpu! alew!lsa eaJe Japu!ewaJ a41 S! q pue 'seaJe SO aUOle-puejs JO Jaqwnu a41 S! Sg '1 eaJe SO auole-puels JOJ aleW!ISa a41 S! 'e aJa4M q+('e~ J :se pap!dap S! aleW!ISa leuO!leu a41 'elnWJoJ e 5u!sn 'eaJe Japu!ewaJ a41 snld seaJe SO auole-puels JOJ SaleW!ISa a41 JO wns a41 aJe UO!le::>!Iqnd S!41 U! palJodaJ se Salew!jsa leuo!leu NM\fO a41 'auole puels aq II!M seaJe SO 4::>!4M paU!WJalap S! I! Jaw ... ~ Sample size and sample allocation DA WN defines precision in terms of the relative standard error (RSE) of an estimate. The RSE is the standard error of the estimate divided by the actual point estimate. DAWN is designed to have RSEs less than or equal to 10% for metropolitan-area estimates, and RSEs less than or equal to 15% for national estimates pertaining to total drug- related visits, cocaine visits, heroin visits, and marijuana visits. As discussed below, these desired precision levels are important drivers for setting sample size targets. Sample sizes for each geographic area were determined by the area's targeted precision level in combination with the theory of optimal allocation for stratified samples. According to this approach, the variance of the sample estimates will be minimized when the sample size, nh, in each sampling stratum is made proportional to the quantity WhS/Ch, where Wh is the proportion of sampling units, Sh is the population standard deviation for the parameter being measured, and Ch represents the square root of the cost of sampling in stratum h. Using these optimum allocation conditions, the minimum required sample sizes necessary to achieve the targeted levels of precision in each DAWN area were calculated using the following general considerations: ID Geographic units for which estimates are desired (national and metropolitan areas described under Stratification), BI Precision level desired (see Target levels of precision), III Specific types of estimates for which minimum precision is desired (e.g., estimates of total, cocaine, heroin, and marijuana ED visits), and III Cost. In addition to these considerations, sampling rates (i.e., the number of sampled hospitals divided by the number of eligible hospitals) were also subject to the following constraints: 11II First, if fewer than four hospitals existed in the stratum population, then all hospitals in the stratum were selected into the sample. II Second, if the sampling rate for a particular stratum was greater than 90%, then all units in the stratum were selected into the sample. III Finally, if any calculations produced a sample size smaller than two hospitals, then the sample size was set to two hospitals. Response rate calculations In 2006, the initial DAWN sample included 1,286 hospitals divided among 53 OS areas (48 MSAs and nine divisions) and one remainder area. Response rates and non response bias analyses were assessed to determine which of these 53 OS areas could stand alone (Figure C3). Once this determination was made, hospitals that were neither dual-purpose nor located in a stand-alone OS area were treated as if they were not sampled. For 2006, this has the effect of reducing the sample from 1,286 hospitals to 544 hospitals, which is the number used for purposes of computing the unweighted response rates (Table C1). Of the 53 original oversample areas, a total of 12 areas (nine metropolitan areas and three submetropolitan areas) were determined to be able to stand alone in 2006. A total of 13 areas were determined to be able to stand DAWN, 2006: NATIONAL ED ESTIMATES 93 ~ ~ S31\fV>lIlS3 03 1\fNOI1\fN :900Z 'NM\fO 1>6 lelOl JO wns pal45!aM a41 01 SI!S!^ lelol fO luno:J \fH\f a41 JO O!leJ a41 se paleln:Jle:J seM JOpeJ luaWlSnfpe a41 'WnleJlS 4:Jea U!41!M 'sawa4:Js UO!le:J!J!leJlS 5u!ldwes paUO!IUaWaJoJe a41 uo paseq paWJoJ aJaM eleJlS UO!le:JY!leJlSlSOd 'luaWlsn[pe S!411UaWaldw! 01 eleJlS U!41!M lUaWlSnfpe O!)eJ e pasn NM\fO 'aseqeleo ^aNns lenuu\f \fH\f lua:JaJ ISOW a41 WOJJ SI!S!^ lelOl JO Jaqwnu a41 41!M Slel!dS04 5U!puodsaJ JOJ SI!S!^ lelOl JO Jaqwnu pal45!aM a41 salPuo:JaJ le41 JOpef luaWlSn[pe UO!je:J!J!leJlSlSod e sapnl:JU! 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()' visits for responding hospitals. The factors were verified to ensure they were within reasonable bounds. If they were out of bounds (either too small or too large), adjacent poststratification strata were collapsed and new poststratification adjustment factors were calculated. When the poststratification adjustment factors were considered final, a poststratified weight was then calculated. The final weight was calculated as the product of the poststratification adjustment factor and the nonresponse- adjusted sampling weight. For each poststratification stratum, a validity check was conducted to ensure that the sum of the poststratified weighted total visits was equal to the corresponding AHA count of total visits from each stratum. Special consideration was given to New Orleans because Hurricane Katrina (on August 29, 2005) and its aftermath caused serious disruptions to the operations of hospitals and, consequently, the DAWN data collection process for the remaining four months of the year. Weight adjustments were implemented by referring to the AHA total counts in combination with a case-by-case study of each hospital in the New Orleans metropolitan area.12 Based on these studies, estimates were made of the proportion of the year that each hospital was open and serving the public. These were used to adjust the AHA totals, which in turn serve as input for population benchmark counts for New Orleans. Total drug-related ED visits Estimates for the entire universe of DAWN-eligible hospitals in the United States are produced by applying poststratified weights to the data received from the sampled hospitals. Thus, for 2006, 269,339 submitted cases were extrapolated to an estimate of 3,441,855 drug-related ED visits. Considering the margin of error, this estimate may range from 3,033,110 to 3,850,600 drug-related ED visits out of more than 113 million total ED visits estimated for the United States (Table C2). Calculation of estimates All estimates produced for this publication were calculated using data that had been weighted according to the plan described above. Estimates for any variable of interest were determined by first summing the case totals within facility-month, applying the within-hospital weight, summing to the hospital level, applying the final hospital weight, and summing over all hospitals. Variance estimation Each hospital in the DAWN sample was selected through a random process, which theoretically could have been repeated many times, resulting in many hypothetical samples. "Sampling variance," or the margin of error, refers to the extent to which these samples vary. Two measures of this variability are the standard error (SE) and the relative standard error (RSE), which is defined as the SE of the estimate divided by the estimate itself. The precision of an estimate is inversely related to the sampling variance, as measured by the RSE. The greater the RSE value, the lower the precision. 12 Information provided by the Louisiana Hospital Association, the Louisiana Public Health Institute, the City of New Orleans Health Department, and available at numerous websites maintained by individual hospitals, news organizations, and State and Federal agencies was invaluable in conducting this assessment. We are grateful for their assistance. DAWN, 2006: NATIONAL ED ESTIMATES 95 " '" S311f~11S3 03 llfNOlllfN :900l 'NMlfO 96 'UO!lelndod a41 U! Ja5Jel S! le41 dnoJ5 a41 JOJ AlleJnleu In:J:Jo 01 papadxa aq PlnOM SI!S!^ 03 JO aleW!ISa Ja45!4 e 'awes a41 5u!aq SJopeJ Ja410 IIV 'vv 019t pa5e Slenp!^!pu! JO Jaqwnu a41 ue41 JaMOI 4:Jnw S! salelS pal!Un a41 U! O((OIIH pa5e Slenp!^!pu! JO Jaqwnu a41 'aldwexa JOJ :sdnoJ5 a5e SSOJ:Je AlqeJap!suo:J SJajJ!p UO!lejndod 5U!ApapUn a41 JO az!s a41 'Jeln:J!lJed U! a5e JO,j 'sap05ale:J Japua5 pue a5e SSOJ:Je salew!lsa JO suospedwo:J P!le^ a~ew 01 papaau aJe saJnseaw paz!pJepUelS SaleJ paz!pJepUelS 'aJeMllOS@Nvvons 5u!sn paleln:Jle:J aJaM SaleW!ISa a:Juepe^ 'UO!leZpeau!l sap as JOIAe1 5u!sn paU!WJalap aJaM UO!le:J!lqnd S!41 U! palJodaJ saleW!lsa a:Juepe^ 'WnleJlS 4:Jea U!41!M SjelOljel!dS04 pal45!aM uaaM}aq a:Juepe^ a41 se paleln:Jle:J seM le41 a:Juepe^ lel!ds04-uaaMlaq a41 ue41 Jallews AlqeJap!suo:J seM lUauodwo:J S!41 'Alle:J!dA1 'uO!lnq!JlUO:J lel!ds04-U!41!M a41 palUasaJdaJ sale:J!ldaJ OMl a41 uaaMlaq a:Juepe^ a41 pue jel!dS04 4:Jea U!41!M paleaJ:J aJaM sale:J!ldaJ WopueJ OMl 4:J!4M Aq A5aleJlS UO!le:J!ldaJ e 5u!sn paleW!ISa seM a:Juepe^ lel!ds04-U!41!M 'JOJ paluno:J:Je aJaM Sluauodwo:J a:Juepe^ lel!ds04-U!41!M pue -uaaMlaq 4108 'aW!1 a41 JO %96 leNalu! a:Juap!Juo:J a41 U!41!M lIeJ PlnoM sanle^ UO!lelndod anJl a41 'saJnpa:JoJd UO!pallo:J elep pue 5u!ldwes awes a41 5u!sn 'Slel!ds04 JO uO!lelndod awes a41 WOJJ UMeJp aJaM saldwes paleadaJ JI '086'0 ~ 01 OZO'6 :18 %96 086'0 ~ = 086 + 000'0 ~ :1!W!1 Jaddn OGO'6 = 086 - 000'0 ~ :1!W!I JaMol 0'086 =+= 000'0 ~ = (OOO'O~ x 90'0 x 96'~) =+= 000'0 ~ :aq PlnOM 18 %96 a41 'a^oqe aldwexa a41 01 elnwJoJ a41 6U!AlddV 'ueaw a41 JO SUO!le!^ap pJepuelS 96' ~ U!41!M sa!l uO!lnqplS!p lewJou a41 JO lua:JJad a^!J-Alau!N 'sanle^-z UO!lnqplS!p leWJOU JO alqel a41 WOJJ sawo:J 96' ~ aJa4M (aleW!IS3 x 3SCl x 96'~) =+= aleW!IS3 = 18 :se paleln:Jje:J S! 18 %96 a41 'SaleW!ISa a41 41!M 5uole lxal a41 U! palP ualJo aJe pue salqel a41 JO Auew U! papnpu! aJe (S18) "SleNalU! a:Juap!Juo:J" 'UO!le:J!lqnd S!41 Uj '%9 JO '90'0 = 3SCl 000'0~/009 = 3SCl alew!IS3/3S = 3SCl :%9 S! anle^ 3SCl a41 ua41 'SI!S!^ 009 JO 3S ue se4 alew!lsa S!41 pue '5nJp ua^!5 e 5u!^10^u! SI!S!^ paleW!ISa 000'0 ~ aJe aJa41 J! 'aldwexa JO,j <=l '" To take the size of the underlying population into account, rates of ED visits per 1 00,000 population were calculated using population data from the U.S. Bureau of the Census.13 For each age and gender category, the estimate for a category was divided by the population for that category, which was then divided by 100,000. For example, consider an estimate of 1,000 visits for an age group of 1,000,000 persons, and an estimate of 1,000 visits for an age group of 500,000 persons. The rates would be calculated as: 1,000 I (1,000,000/100,000) = 1,000/10 = 100 visits per 100,000 population 1,000 I (500,000/100,000) = 1,000/5 = 200 visits per 100,000 population. Population estimates used to generate rates for 2006 are provided in Table C5. Table C5 Population by age and gender: 20061 Gender and age Total United States Males Females Total 302,225,862 149,002,083 153,223,779 0-5 years 24,640,694 12,601,585 12,039,109 6-11 years 23,807,562 12,174,360 11,633,202 12-17 years 25,447,520 13,037,107 12,410,413 18-20 years 12,674,580 6,507,886 6,166,694 21-24 years 16,977,014 8,780,282 8,196,732 25-29 years 21,221,621 10,871,501 10,350,120 30-34 years 19,655,279 9,974,102 9,681,177 35-44 years 43,297,681 21,691,759 21,605,922 45-54 years 43,932,378 21,623,7 41 22,308,637 55-65 years 32,737,374 15,786,874 16,950,500 65 years and older 37,834,159 15,952,886 21,881,273 1 Population estimates for 2006 are, as of 6/9/2008, from the U.S. Bureau of Census Postcensal Resident Population National Population Dataset, National estimates by demographic characteristics - single year of age, sex and race, and Hispanic Origin, Monthly Population Estimates. Link: http://www.census.gov/popest/datasetshtml. File: NC-EST2007 -ALLDATA-R-File14.csv. Standardized rates were not calculated for race and ethnicity subgroups, because the racelethnicity categories available to DAWN are much less detailed and contain considerably more missing data than the race and ethnicity categories in the Census data. Appendix 0 describes the race and ethnicity data reported for DAWN. 13 Population estimates for 2006 are, as of 6/9/2008, from the U.S. Bureau of Census Postcensal Resident Population National Population Dataset, National estimates by demographic characteristics - single year of age, sex and race, and Hispanic Origin, Monthly Population Estimates. Link: http://www.census.gov/popestldatasetshlml. File: NC-EST2007 -ALLDA T A-R-File14.csv. DAWN, 2006: NATIONAL ED ESTIMATES 97 .. .. 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APPENDIX D RACE AND ETHNICITY IN DAWN In October 1997, the Office of Management and Budget (OMB) issued a revised standard protocol for race and ethnicity categories used in Federal data collection systems.1 The new protocol permitted separate reporting of race and Hispanic ethnicity, and it incorporated the ability to capture more than one race for an individual, a few modifications in nomenclature (e.g., "black" was changed to "black or African American"), division of certain categories ("Asian or Pacific Islander" was split into two categories, "Asian" and "Native Hawaiian or Other Pacific Islander"), and elimination of the "other" category. For data collections such as DAWN, where self-identification of the individual is not feasible (no patient is interviewed for DAWN), the OMB protocol also permitted a combined format, whereby race and Hispanic ethnicity would be recorded in a single data item, which could still record multiple entries for race and/or Hispanic ethnicity. The single data item for race and ethnicity is shown in the DAWN ED case form that has been used since 2003 (Appendix C, Figure C1). Despite the increased detail allowed by the new categories and the provision for multiple entries, the actual race/ethnicity data extracted from source records and submitted to DAWN is quite limited. This is because the source documents (i.e., the ED medical records from which DAWN data are abstracted) rarely contain such detailed information on race/ethnicity of patients. For reference, estimates of drug-related ED visits by race/ethnicity are presented in Table D1. This analysis, which is based on the most detailed coding of race/ethnicity in DAWN case reports, reveals that estimates for the following categories are too small to be meaningful: II Multiple (i.e., two or more) races/ethnicities (i.e., two or more races/ethnicities were documented in the source record for the same individual), II Hispanic or Latino ethnicity with any specific race indicated, III American Indian or Alaska Native, HI Asian, and II Native Hawaiian or Other Pacific Islander. Therefore, in the tables of estimates in this and other DAWN publications we have retained a more limited set of categories: white, black, and Hispanic. A fourth category, called "Race/ethnicity not tabulated above (NTA)," is used to tabulate those categories that are too small to report independently.2 All cases reported to DAWN as Hispanic or Latino ethnicity are tabulated as Hispanic race/ethnicity, regardless of race. 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