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<br /> F Bust Bio-AyicWtural Services Inc. 4 806-328-9760 :31 /31 /97 <br /> r,~2:26 PM _,12/14 <br /> More unusual and extreme reactions have included diarrhea, lack of bladder <br /> control, temporary amnesia, and sleep-walking. Whatever side effects may <br /> be <br /> noted, they are often much more severe when GHB is combined with other <br /> central nervous system depressants [Chin and Kreutzer, 1992, Gallimberti, <br /> 1989; Takahara, 1977; Vickers, 1969]. <br /> Contraindications <br /> r <br /> Although contraindications for GHB have been described as "remarkably <br /> few" <br /> [Vickers, 1 g69], those who suffer from any of the following conditions <br /> should not use GHB: severe illness of any kind, epilepsy, eclampsia <br /> (convulsions), bradycardia (slowed heart-beat) due to conduction problems <br /> [left-bundle-branch-block is an example of conduction difficulty], <br /> Cushing's <br /> syndrome, severe cardiovascular disease, hyperprolactinemia, and severe <br /> hypertension [Gallimberti, 1989; Vickers, 1969]. <br /> Severe alcoholism is sometimes mentioned as a contraindication for GHB <br /> [Smart Drugs II, page 244] even though GHB has been used quite <br /> successfully <br /> in the treatment of withdrawal symptoms. The explanation for this <br /> seeming <br /> contradiction probably lies in the likelihood that severe alcoholics may <br /> combine GHB with alcohol. <br /> GHB should not be used with benzodiazepines ("minor tranquilizers" such <br /> as <br /> Valium and Xanax), phenothiazines ("major tranquilizers" like Thorazine <br /> and <br /> Stellazine), various painkillers (barbiturates and opiates), alcohol, <br /> anticonvulsants (Dilantin and phenobarbital) and even many over-the- <br /> counter <br /> allergy and sleep remedies without direct medical supervision. <br /> Dosage <br /> Determining the ideal dose is probably the trickiest aspect of working <br /> with <br /> <br />