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<br /> Feuer Bio-Agricultural Ssrvicse Ina iQ 808]28-9760 $1131197 G 2:21 PM ~ 6116 <br /> fi <br /> fi <br /> t <br /> II, p. 245]. Small doses produce relaxation, tranquility and drowsiness <br /> which make it extremely easy to fall asleep naturally. Higher doses <br /> increase <br /> the drowsiness effect and decrease the time it takes to fall asleep. A <br /> sufficiently large dose of GHB will induce sudden sleep within five to ten <br /> minutes [Laborit, 1964]. Many other hypnotics interfere with various <br /> stages <br /> of the sleep cycle thus preventing the body from achieving a complete and <br /> balanced session of rest and recuperation. The most remarkable facet of <br /> GHB-induced sleep is its physiological resemblance to normal sleep. For' <br /> instance, GHB sleep is characterized by increased levels of carbon dioxide <br /> in the arteries, as in normal sleep [Vickers, 1969]. During normal and GHB <br /> sleep, the CNS continues to be responsive to "noxious stimuli" (pain and <br /> other irritations), a factor which sets limits on GHB's uses in anesthesia <br /> [Vickers, 1969]. GHB facilitates both REM (rapid eye movement) sleep, and <br /> "slow-wave" (non-REM) sleep, the stage of sleep featuring increased <br /> release <br /> of growth hormone [Laborit, 1972]. And unlike the unconsciousness induced <br /> by <br /> other anesthetics, that triggered by GHB does not feature a systemic <br /> decrease in oxygen consumption [Laborit, 1 964). <br /> The primary disadvantage to GHB's use as a sleep aid is it's short-term <br /> influence about three hours. During GHB's influence, sleep is deeper and <br /> more restful, but after the GHB has worn off, people have a tendency to <br /> wake <br /> up. The higher the dose, the greater is this tendency. Some have called this <br /> pattern the "dawn effect" and have speculated that it is related to the <br /> release of stored-up dopamine. Some people minimize this effect by <br /> taking <br /> minimal doses of GHB. Others take advantage of this effect by getting a <br /> couple of hours of work done in the middle of the night. Still others choose <br /> to take a second dose of GHB to sleep for another three hours. <br /> It should be noted that not everyone can be put to sleep by GHB. We have <br /> spoken to three men who have never achieved sleep even with the doses <br /> normally used for such purposes. In addition, Takahara [1 977] reported <br /> that <br /> one of the six men in the growth hormone study cited above remained <br /> conscious even though he had received two and a half grams of GHB <br /> <br />