COM 0093.013 1998-2000 - Laserfiche WebLink

Home

�� • -.� I uL- klb : Jb Ym /ashkln, Simmons, Sheriil, [f of.; Mu0 and Annual Charge in FEVs A s.00 4.60 3.00 2.60 AGE (yr&) Arvala a6dIN NOeA4WANA ----- 1{X2NT{pA1 140INTSMAY M "V, (fit 331 3aS all O P-05 145 6.00 4.50 4.00 , IL I 3.601 &00 I 2.60 00 36 40 IS s0 as So AGE An" 6{rfM NOTOaACCO •••-• to CIG/DAY 27 CI%DAY Y FEV, 04- Saa 40A 411.3 Figure 2. Oeclines in FEVs (In liters) with age (in years) by intensity of smoking marijuana (A) or tobacco (8), estimated from random -effects model In man. Slope coefficients for annual dgdine in FEVs (in milliliters) for smokers of 0, 1.5, 3.0 joints/d (A) or 0, 18, and 27 tobacco cigarettesid (6) are shown at the bottom or the figure. the similarity or the annual rate of decline in FEV, in the com- bined smokers of marijuana and lobacco and in the nonsmok- Ing control subjects, in contrast to the accelerated rate of decline found among the tobacco -only smokers (Figure IA). Although the dynamics of recruiting the different smoking groups were similar, we cannot exclude the possibility that the results in the dual smokers of marijuana and tobacco might have been in- fluenced by an inadvertent sampling bias. Nonetheless, overall, the findings in the present study do not support an association between even heavy, regular marijuana smoking and the devel- opment of chronic obstructive pulmonary disease (COPD). These findings are at variance with the results of a previous longitudinal study in which data were analyzed fromastratified random sample (n - 856) of young adult residents (age 6 40 NEVER TOBACCO SMOKERS A a.00 Clio[ i 4.00 r 3.50 3.00 2.60' 30 36 40 46 6o so t IWAVUAN4t AGA loss) A.nYaI tladv NEVER -••-- RITaANnTENT coNnNylba IN FE'11, Owl; aha na eaa Yr) of Tucson, Arizona (19). The latter sample, which included leu than 100 self-reported smokers of nontobacco (marijuana) either alone or with tobacco at study entry, had lung function measured in 210 4 surveys conducted every 2 yr over a maximum span of 8 yr. In the latter study, the estimated annual decline in FEV, attributed to marijuana smoking reported at least dur- ing the initial survey was 142 ml/yr, which was equivalent to ap- proximately 501a of the predicted FEV„ in contrast to an expected rate of decline of approximately I0/4 of predicted FEV, In non- smokers. In the same study, moreover, the annual decrement in FEV, among the marijuana smokers was twice as large as the estimated annual decline due to current tobacco cigarette smok- ing (68 ml), and theeffects of smoking both types of substances were additive (19). a A.00 4.50 r 4.00 F � 3.50- 3.00 a.so CONTINUING TOBACCO SMOKERS 30 33 40 45 SO 66 e0 eAAlxA1114 AGE tyro) MrbY tlmr NMR ••--- INTERWMIT eONTINUU/a F FN, ally 60.2 1 4011 Y4 Figure I. Declines In FEVI (in liters) with age (in years) by continuity of marijuana smoking (never, Intermittent, and continuing), estimated from linear random -effects model among male never tobacco smokers (A) and continufng tobacco smokers (a). Slope coefficients for annual electing in FEVI (in milliliters) In never, intermittent, and continuing marijuana smokers are shown at boftam of each panel.